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Protective role of endogenous melatonin in the early course of human acute pancreatitis.

Abstract

Melatonin plays a protective role in experimental acute pancreatitis (AP) because of its antioxidative, antiinflammatory, and immunomodulatory effects. This study presents the first data on the dynamic changes of endogenous melatonin in the early phase of human AP. Morning (08:00 hr) serum melatonin concentrations were measured by ELISA in 75 patients with AP for the first 5 days after the onset of pain. According to the Atlanta classification, 26 patients suffered a mild AP (MAP). The other 49 developed a severe AP (SAP). Median melatonin concentrations of healthy volunteers were used as a control. Median melatonin level in healthy controls was 18.5 pg/mL. Levels of melatonin were significantly higher in the first 24 hr after onset of disease in patients with MAP compared to those with SAP, 51.2 versus 8.7 pg/mL (P = 0.01). Melatonin values were the same in MAP and SAP during the remainder of the study period. Melatonin concentrations during the first 24 hr after the onset of pain in younger patients (<35 yrs old) were significantly higher than levels in older patients (>35 yrs): 73 versus 8.7 pg/mL (P = 0.01). No correlation existed between melatonin levels and the following parameters: gender, etiology (biliary versus alcohol induced), and histological findings (edematous versus necrotizing versus infected necrosis). High endogenous melatonin serum levels in the first 24 hr after the onset of AP played a protective role and favoured a mild course of the disease in humans, especially in young patients.

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  • Authors+Show Affiliations

    ,

    Department of Surgery, St Josef Hospital, Ruhr University of Bochum, Bochum, Germany. o.belyaev@klinikum-bochum.de

    , , , , ,

    Source

    Journal of pineal research 50:1 2011 Jan pg 71-7

    MeSH

    Acute Disease
    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Anti-Inflammatory Agents
    Antioxidants
    Enzyme-Linked Immunosorbent Assay
    Female
    Humans
    Immunologic Factors
    Male
    Melatonin
    Middle Aged
    Pancreatitis
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20964708

    Citation

    Belyaev, Orlin, et al. "Protective Role of Endogenous Melatonin in the Early Course of Human Acute Pancreatitis." Journal of Pineal Research, vol. 50, no. 1, 2011, pp. 71-7.
    Belyaev O, Herzog T, Munding J, et al. Protective role of endogenous melatonin in the early course of human acute pancreatitis. J Pineal Res. 2011;50(1):71-7.
    Belyaev, O., Herzog, T., Munding, J., Bolik, B., Vosschulte, A., Uhl, W., & Müller, C. A. (2011). Protective role of endogenous melatonin in the early course of human acute pancreatitis. Journal of Pineal Research, 50(1), pp. 71-7. doi:10.1111/j.1600-079X.2010.00811.x.
    Belyaev O, et al. Protective Role of Endogenous Melatonin in the Early Course of Human Acute Pancreatitis. J Pineal Res. 2011;50(1):71-7. PubMed PMID: 20964708.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Protective role of endogenous melatonin in the early course of human acute pancreatitis. AU - Belyaev,Orlin, AU - Herzog,Torsten, AU - Munding,Johanna, AU - Bolik,Bernd, AU - Vosschulte,Andreas, AU - Uhl,Waldemar, AU - Müller,Christophe A, Y1 - 2010/10/22/ PY - 2010/10/23/entrez PY - 2010/10/23/pubmed PY - 2011/4/6/medline SP - 71 EP - 7 JF - Journal of pineal research JO - J. Pineal Res. VL - 50 IS - 1 N2 - Melatonin plays a protective role in experimental acute pancreatitis (AP) because of its antioxidative, antiinflammatory, and immunomodulatory effects. This study presents the first data on the dynamic changes of endogenous melatonin in the early phase of human AP. Morning (08:00 hr) serum melatonin concentrations were measured by ELISA in 75 patients with AP for the first 5 days after the onset of pain. According to the Atlanta classification, 26 patients suffered a mild AP (MAP). The other 49 developed a severe AP (SAP). Median melatonin concentrations of healthy volunteers were used as a control. Median melatonin level in healthy controls was 18.5 pg/mL. Levels of melatonin were significantly higher in the first 24 hr after onset of disease in patients with MAP compared to those with SAP, 51.2 versus 8.7 pg/mL (P = 0.01). Melatonin values were the same in MAP and SAP during the remainder of the study period. Melatonin concentrations during the first 24 hr after the onset of pain in younger patients (<35 yrs old) were significantly higher than levels in older patients (>35 yrs): 73 versus 8.7 pg/mL (P = 0.01). No correlation existed between melatonin levels and the following parameters: gender, etiology (biliary versus alcohol induced), and histological findings (edematous versus necrotizing versus infected necrosis). High endogenous melatonin serum levels in the first 24 hr after the onset of AP played a protective role and favoured a mild course of the disease in humans, especially in young patients. SN - 1600-079X UR - https://www.unboundmedicine.com/medline/citation/20964708/full_citation L2 - https://doi.org/10.1111/j.1600-079X.2010.00811.x DB - PRIME DP - Unbound Medicine ER -