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Genetic epidemiology of hip and knee osteoarthritis.
Nat Rev Rheumatol 2011; 7(1):23-32NR

Abstract

Osteoarthritis (OA) is the most common cause of arthritis and represents an enormous healthcare burden in industrialized societies. Current therapeutic approaches for OA are limited and are insufficient to prevent the initiation and progression of the disease. Genetic studies of patients with OA can help to unravel the molecular mechanisms responsible for specific disease manifestations, including joint damage, nociception and chronic pain. Indeed, these studies have identified molecules, such as growth/differentiation factor 5, involved in signaling cascades that are important for the pathology of joint components. Genome-wide association studies have uncovered a likely role in OA for the genes encoding structural extracellular matrix components (such as DVWA) and molecules involved in prostaglandin metabolism (such as DQB1 and BTNL2). A ∼300 kilobase region in chromosome 7q22 is also associated with OA susceptibility. Finally, the identification of individuals at a high risk of OA and of total joint arthroplasty failure might be facilitated by the use of combinations of genetic markers, allowing for the application of preventive and disease-management strategies.

Authors+Show Affiliations

Department of Twin Research & Genetic Epidemiology, St. Thomas' Hospital, Kings College London School of Medicine, London SE1 7EH, UK. ana.valdes@kcl.ac.ukNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21079645

Citation

Valdes, Ana M., and Tim D. Spector. "Genetic Epidemiology of Hip and Knee Osteoarthritis." Nature Reviews. Rheumatology, vol. 7, no. 1, 2011, pp. 23-32.
Valdes AM, Spector TD. Genetic epidemiology of hip and knee osteoarthritis. Nat Rev Rheumatol. 2011;7(1):23-32.
Valdes, A. M., & Spector, T. D. (2011). Genetic epidemiology of hip and knee osteoarthritis. Nature Reviews. Rheumatology, 7(1), pp. 23-32. doi:10.1038/nrrheum.2010.191.
Valdes AM, Spector TD. Genetic Epidemiology of Hip and Knee Osteoarthritis. Nat Rev Rheumatol. 2011;7(1):23-32. PubMed PMID: 21079645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic epidemiology of hip and knee osteoarthritis. AU - Valdes,Ana M, AU - Spector,Tim D, Y1 - 2010/11/16/ PY - 2010/11/17/entrez PY - 2010/11/17/pubmed PY - 2011/4/16/medline SP - 23 EP - 32 JF - Nature reviews. Rheumatology JO - Nat Rev Rheumatol VL - 7 IS - 1 N2 - Osteoarthritis (OA) is the most common cause of arthritis and represents an enormous healthcare burden in industrialized societies. Current therapeutic approaches for OA are limited and are insufficient to prevent the initiation and progression of the disease. Genetic studies of patients with OA can help to unravel the molecular mechanisms responsible for specific disease manifestations, including joint damage, nociception and chronic pain. Indeed, these studies have identified molecules, such as growth/differentiation factor 5, involved in signaling cascades that are important for the pathology of joint components. Genome-wide association studies have uncovered a likely role in OA for the genes encoding structural extracellular matrix components (such as DVWA) and molecules involved in prostaglandin metabolism (such as DQB1 and BTNL2). A ∼300 kilobase region in chromosome 7q22 is also associated with OA susceptibility. Finally, the identification of individuals at a high risk of OA and of total joint arthroplasty failure might be facilitated by the use of combinations of genetic markers, allowing for the application of preventive and disease-management strategies. SN - 1759-4804 UR - https://www.unboundmedicine.com/medline/citation/21079645/full_citation L2 - http://dx.doi.org/10.1038/nrrheum.2010.191 DB - PRIME DP - Unbound Medicine ER -