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Genetic epidemiology of hip and knee osteoarthritis.

Abstract

Osteoarthritis (OA) is the most common cause of arthritis and represents an enormous healthcare burden in industrialized societies. Current therapeutic approaches for OA are limited and are insufficient to prevent the initiation and progression of the disease. Genetic studies of patients with OA can help to unravel the molecular mechanisms responsible for specific disease manifestations, including joint damage, nociception and chronic pain. Indeed, these studies have identified molecules, such as growth/differentiation factor 5, involved in signaling cascades that are important for the pathology of joint components. Genome-wide association studies have uncovered a likely role in OA for the genes encoding structural extracellular matrix components (such as DVWA) and molecules involved in prostaglandin metabolism (such as DQB1 and BTNL2). A ∼300 kilobase region in chromosome 7q22 is also associated with OA susceptibility. Finally, the identification of individuals at a high risk of OA and of total joint arthroplasty failure might be facilitated by the use of combinations of genetic markers, allowing for the application of preventive and disease-management strategies.

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    Authors+Show Affiliations

    Valdes AM
    ,

    Department of Twin Research & Genetic Epidemiology, St. Thomas' Hospital, Kings College London School of Medicine, London SE1 7EH, UK. ana.valdes@kcl.ac.uk

    Spector TD

    Source

    Nature reviews. Rheumatology 7:1 2011 Jan pg 23-32

    MeSH

    Collagen Type VI
    Genetic Predisposition to Disease
    Growth Differentiation Factor 5
    Humans
    Osteoarthritis, Hip
    Osteoarthritis, Knee
    Prostaglandins
    Pseudogenes
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    21079645

    Citation

    Valdes, Ana M., and Tim D. Spector. "Genetic Epidemiology of Hip and Knee Osteoarthritis." Nature Reviews. Rheumatology, vol. 7, no. 1, 2011, pp. 23-32.
    Valdes AM, Spector TD. Genetic epidemiology of hip and knee osteoarthritis. Nat Rev Rheumatol. 2011;7(1):23-32.
    Valdes, A. M., & Spector, T. D. (2011). Genetic epidemiology of hip and knee osteoarthritis. Nature Reviews. Rheumatology, 7(1), pp. 23-32. doi:10.1038/nrrheum.2010.191.
    Valdes AM, Spector TD. Genetic Epidemiology of Hip and Knee Osteoarthritis. Nat Rev Rheumatol. 2011;7(1):23-32. PubMed PMID: 21079645.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Genetic epidemiology of hip and knee osteoarthritis. AU - Valdes,Ana M, AU - Spector,Tim D, Y1 - 2010/11/16/ PY - 2010/11/17/entrez PY - 2010/11/17/pubmed PY - 2011/4/16/medline SP - 23 EP - 32 JF - Nature reviews. Rheumatology JO - Nat Rev Rheumatol VL - 7 IS - 1 N2 - Osteoarthritis (OA) is the most common cause of arthritis and represents an enormous healthcare burden in industrialized societies. Current therapeutic approaches for OA are limited and are insufficient to prevent the initiation and progression of the disease. Genetic studies of patients with OA can help to unravel the molecular mechanisms responsible for specific disease manifestations, including joint damage, nociception and chronic pain. Indeed, these studies have identified molecules, such as growth/differentiation factor 5, involved in signaling cascades that are important for the pathology of joint components. Genome-wide association studies have uncovered a likely role in OA for the genes encoding structural extracellular matrix components (such as DVWA) and molecules involved in prostaglandin metabolism (such as DQB1 and BTNL2). A ∼300 kilobase region in chromosome 7q22 is also associated with OA susceptibility. Finally, the identification of individuals at a high risk of OA and of total joint arthroplasty failure might be facilitated by the use of combinations of genetic markers, allowing for the application of preventive and disease-management strategies. SN - 1759-4804 UR - https://www.unboundmedicine.com/medline/citation/21079645/full_citation L2 - http://dx.doi.org/10.1038/nrrheum.2010.191 DB - PRIME DP - Unbound Medicine ER -