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Marine fatty acid intake is associated with breast cancer prognosis.
J Nutr 2011; 141(2):201-6JN

Abstract

EPA and DHA, long-chain (n-3) PUFA largely obtained from fish, inhibit the proliferation of breast cancer cells in vitro and reduce the initiation and progression of breast tumors in laboratory animals. Our purpose in this analysis was to examine whether intake of these marine fatty acids (EPA and DHA) were associated with prognosis in a cohort of women who had been diagnosed and treated for early stage breast cancer (n = 3,081). Median follow-up was 7.3 y. Dietary intake was assessed using 24-h recalls (~4 recalls per dietary assessment obtained at 7 time points over 6 y). Survival models with time-dependent covariates were used to examine the association of repeated measures of dietary intake of EPA and DHA from food (i.e., marine sources) and supplements with disease-free survival and overall survival. Women with higher intakes of EPA and DHA from food had an approximate 25% reduced risk of additional breast cancer events [tertile 2: HR = 0.74 (95% CI = 0.58-0.94); tertile 3: HR = 0.72 (95% CI = 0.57-0.90)] compared with the lowest tertile of intake. Women with higher intakes of EPA and DHA from food had a dose-dependent reduced risk of all-cause mortality [tertile 2: HR = 0.75 (95% CI = 0.55-1.04); tertile 3: HR = 0.59 (95% CI = 0.43-0.82)]. EPA and DHA intake from fish oil supplements was not associated with breast cancer outcomes. The investigation indicates that marine fatty acids from food are associated with reduced risk of additional breast cancer events and all-cause mortality.

Authors+Show Affiliations

Moores UCSD Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA. repatterson@ucsd.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21178081

Citation

Patterson, Ruth E., et al. "Marine Fatty Acid Intake Is Associated With Breast Cancer Prognosis." The Journal of Nutrition, vol. 141, no. 2, 2011, pp. 201-6.
Patterson RE, Flatt SW, Newman VA, et al. Marine fatty acid intake is associated with breast cancer prognosis. J Nutr. 2011;141(2):201-6.
Patterson, R. E., Flatt, S. W., Newman, V. A., Natarajan, L., Rock, C. L., Thomson, C. A., ... Pierce, J. P. (2011). Marine fatty acid intake is associated with breast cancer prognosis. The Journal of Nutrition, 141(2), pp. 201-6. doi:10.3945/jn.110.128777.
Patterson RE, et al. Marine Fatty Acid Intake Is Associated With Breast Cancer Prognosis. J Nutr. 2011;141(2):201-6. PubMed PMID: 21178081.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marine fatty acid intake is associated with breast cancer prognosis. AU - Patterson,Ruth E, AU - Flatt,Shirley W, AU - Newman,Vicky A, AU - Natarajan,Loki, AU - Rock,Cheryl L, AU - Thomson,Cynthia A, AU - Caan,Bette J, AU - Parker,Barbara A, AU - Pierce,John P, Y1 - 2010/12/22/ PY - 2010/12/24/entrez PY - 2010/12/24/pubmed PY - 2011/2/24/medline SP - 201 EP - 6 JF - The Journal of nutrition JO - J. Nutr. VL - 141 IS - 2 N2 - EPA and DHA, long-chain (n-3) PUFA largely obtained from fish, inhibit the proliferation of breast cancer cells in vitro and reduce the initiation and progression of breast tumors in laboratory animals. Our purpose in this analysis was to examine whether intake of these marine fatty acids (EPA and DHA) were associated with prognosis in a cohort of women who had been diagnosed and treated for early stage breast cancer (n = 3,081). Median follow-up was 7.3 y. Dietary intake was assessed using 24-h recalls (~4 recalls per dietary assessment obtained at 7 time points over 6 y). Survival models with time-dependent covariates were used to examine the association of repeated measures of dietary intake of EPA and DHA from food (i.e., marine sources) and supplements with disease-free survival and overall survival. Women with higher intakes of EPA and DHA from food had an approximate 25% reduced risk of additional breast cancer events [tertile 2: HR = 0.74 (95% CI = 0.58-0.94); tertile 3: HR = 0.72 (95% CI = 0.57-0.90)] compared with the lowest tertile of intake. Women with higher intakes of EPA and DHA from food had a dose-dependent reduced risk of all-cause mortality [tertile 2: HR = 0.75 (95% CI = 0.55-1.04); tertile 3: HR = 0.59 (95% CI = 0.43-0.82)]. EPA and DHA intake from fish oil supplements was not associated with breast cancer outcomes. The investigation indicates that marine fatty acids from food are associated with reduced risk of additional breast cancer events and all-cause mortality. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/21178081/full_citation L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.110.128777 DB - PRIME DP - Unbound Medicine ER -