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Marine fatty acid intake is associated with breast cancer prognosis.

Abstract

EPA and DHA, long-chain (n-3) PUFA largely obtained from fish, inhibit the proliferation of breast cancer cells in vitro and reduce the initiation and progression of breast tumors in laboratory animals. Our purpose in this analysis was to examine whether intake of these marine fatty acids (EPA and DHA) were associated with prognosis in a cohort of women who had been diagnosed and treated for early stage breast cancer (n = 3,081). Median follow-up was 7.3 y. Dietary intake was assessed using 24-h recalls (~4 recalls per dietary assessment obtained at 7 time points over 6 y). Survival models with time-dependent covariates were used to examine the association of repeated measures of dietary intake of EPA and DHA from food (i.e., marine sources) and supplements with disease-free survival and overall survival. Women with higher intakes of EPA and DHA from food had an approximate 25% reduced risk of additional breast cancer events [tertile 2: HR = 0.74 (95% CI = 0.58-0.94); tertile 3: HR = 0.72 (95% CI = 0.57-0.90)] compared with the lowest tertile of intake. Women with higher intakes of EPA and DHA from food had a dose-dependent reduced risk of all-cause mortality [tertile 2: HR = 0.75 (95% CI = 0.55-1.04); tertile 3: HR = 0.59 (95% CI = 0.43-0.82)]. EPA and DHA intake from fish oil supplements was not associated with breast cancer outcomes. The investigation indicates that marine fatty acids from food are associated with reduced risk of additional breast cancer events and all-cause mortality.

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    ,

    Moores UCSD Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA. repatterson@ucsd.edu

    , , , , , , ,

    Source

    The Journal of nutrition 141:2 2011 Feb pg 201-6

    MeSH

    Adult
    Animals
    Breast Neoplasms
    Diet Records
    Dietary Fats
    Docosahexaenoic Acids
    Dose-Response Relationship, Drug
    Eicosapentaenoic Acid
    Female
    Fishes
    Humans
    Middle Aged
    Prognosis
    Proportional Hazards Models
    Risk
    Risk Factors
    Seafood

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21178081

    Citation

    Patterson, Ruth E., et al. "Marine Fatty Acid Intake Is Associated With Breast Cancer Prognosis." The Journal of Nutrition, vol. 141, no. 2, 2011, pp. 201-6.
    Patterson RE, Flatt SW, Newman VA, et al. Marine fatty acid intake is associated with breast cancer prognosis. J Nutr. 2011;141(2):201-6.
    Patterson, R. E., Flatt, S. W., Newman, V. A., Natarajan, L., Rock, C. L., Thomson, C. A., ... Pierce, J. P. (2011). Marine fatty acid intake is associated with breast cancer prognosis. The Journal of Nutrition, 141(2), pp. 201-6. doi:10.3945/jn.110.128777.
    Patterson RE, et al. Marine Fatty Acid Intake Is Associated With Breast Cancer Prognosis. J Nutr. 2011;141(2):201-6. PubMed PMID: 21178081.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Marine fatty acid intake is associated with breast cancer prognosis. AU - Patterson,Ruth E, AU - Flatt,Shirley W, AU - Newman,Vicky A, AU - Natarajan,Loki, AU - Rock,Cheryl L, AU - Thomson,Cynthia A, AU - Caan,Bette J, AU - Parker,Barbara A, AU - Pierce,John P, Y1 - 2010/12/22/ PY - 2010/12/24/entrez PY - 2010/12/24/pubmed PY - 2011/2/24/medline SP - 201 EP - 6 JF - The Journal of nutrition JO - J. Nutr. VL - 141 IS - 2 N2 - EPA and DHA, long-chain (n-3) PUFA largely obtained from fish, inhibit the proliferation of breast cancer cells in vitro and reduce the initiation and progression of breast tumors in laboratory animals. Our purpose in this analysis was to examine whether intake of these marine fatty acids (EPA and DHA) were associated with prognosis in a cohort of women who had been diagnosed and treated for early stage breast cancer (n = 3,081). Median follow-up was 7.3 y. Dietary intake was assessed using 24-h recalls (~4 recalls per dietary assessment obtained at 7 time points over 6 y). Survival models with time-dependent covariates were used to examine the association of repeated measures of dietary intake of EPA and DHA from food (i.e., marine sources) and supplements with disease-free survival and overall survival. Women with higher intakes of EPA and DHA from food had an approximate 25% reduced risk of additional breast cancer events [tertile 2: HR = 0.74 (95% CI = 0.58-0.94); tertile 3: HR = 0.72 (95% CI = 0.57-0.90)] compared with the lowest tertile of intake. Women with higher intakes of EPA and DHA from food had a dose-dependent reduced risk of all-cause mortality [tertile 2: HR = 0.75 (95% CI = 0.55-1.04); tertile 3: HR = 0.59 (95% CI = 0.43-0.82)]. EPA and DHA intake from fish oil supplements was not associated with breast cancer outcomes. The investigation indicates that marine fatty acids from food are associated with reduced risk of additional breast cancer events and all-cause mortality. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/21178081/full_citation L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.110.128777 DB - PRIME DP - Unbound Medicine ER -