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Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4).

Abstract

BACKGROUND

Heavy alcohol drinking has been related to pancreatic cancer, but the issue is still unsolved.

METHODS

To evaluate the role of alcohol consumption in relation to pancreatic cancer, we conducted a pooled analysis of 10 case-control studies (5585 cases and 11,827 controls) participating in the International Pancreatic Cancer Case-Control Consortium. We computed pooled odds ratios (ORs) by estimating study-specific ORs adjusted for selected covariates and pooling them using random effects models.

RESULTS

Compared with abstainers and occasional drinkers (< 1 drink per day), we observed no association for light-to-moderate alcohol consumption (≤ 4 drinks per day) and pancreatic cancer risk; however, associations were above unity for higher consumption levels (OR = 1.6, 95% confidence interval 1.2-2.2 for subjects drinking ≥ 9 drinks per day). Results did not change substantially when we evaluated associations by tobacco smoking status, or when we excluded participants who reported a history of pancreatitis, or participants whose data were based upon proxy responses. Further, no notable differences in pooled risk estimates emerged across strata of sex, age, race, study type, and study area.

CONCLUSION

This collaborative-pooled analysis provides additional evidence for a positive association between heavy alcohol consumption and the risk of pancreatic cancer.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri Milan, Milan, Italy.

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    Source

    MeSH

    Adult
    Aged
    Alcohol Drinking
    Case-Control Studies
    Confounding Factors (Epidemiology)
    Female
    Humans
    Logistic Models
    Male
    Middle Aged
    Odds Ratio
    Pancreatic Neoplasms
    Pancreatitis
    Risk Factors
    Smoking

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, N.I.H., Extramural
    Research Support, N.I.H., Intramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21536662

    Citation

    Lucenteforte, E, et al. "Alcohol Consumption and Pancreatic Cancer: a Pooled Analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 23, no. 2, 2012, pp. 374-82.
    Lucenteforte E, La Vecchia C, Silverman D, et al. Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4). Ann Oncol. 2012;23(2):374-82.
    Lucenteforte, E., La Vecchia, C., Silverman, D., Petersen, G. M., Bracci, P. M., Ji, B. T., ... Duell, E. J. (2012). Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4). Annals of Oncology : Official Journal of the European Society for Medical Oncology, 23(2), pp. 374-82. doi:10.1093/annonc/mdr120.
    Lucenteforte E, et al. Alcohol Consumption and Pancreatic Cancer: a Pooled Analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4). Ann Oncol. 2012;23(2):374-82. PubMed PMID: 21536662.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4). AU - Lucenteforte,E, AU - La Vecchia,C, AU - Silverman,D, AU - Petersen,G M, AU - Bracci,P M, AU - Ji,B T, AU - Bosetti,C, AU - Li,D, AU - Gallinger,S, AU - Miller,A B, AU - Bueno-de-Mesquita,H B, AU - Talamini,R, AU - Polesel,J, AU - Ghadirian,P, AU - Baghurst,P A, AU - Zatonski,W, AU - Fontham,E, AU - Bamlet,W R, AU - Holly,E A, AU - Gao,Y T, AU - Negri,E, AU - Hassan,M, AU - Cotterchio,M, AU - Su,J, AU - Maisonneuve,P, AU - Boffetta,P, AU - Duell,E J, Y1 - 2011/05/02/ PY - 2011/5/4/entrez PY - 2011/5/4/pubmed PY - 2012/5/23/medline SP - 374 EP - 82 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 23 IS - 2 N2 - BACKGROUND: Heavy alcohol drinking has been related to pancreatic cancer, but the issue is still unsolved. METHODS: To evaluate the role of alcohol consumption in relation to pancreatic cancer, we conducted a pooled analysis of 10 case-control studies (5585 cases and 11,827 controls) participating in the International Pancreatic Cancer Case-Control Consortium. We computed pooled odds ratios (ORs) by estimating study-specific ORs adjusted for selected covariates and pooling them using random effects models. RESULTS: Compared with abstainers and occasional drinkers (< 1 drink per day), we observed no association for light-to-moderate alcohol consumption (≤ 4 drinks per day) and pancreatic cancer risk; however, associations were above unity for higher consumption levels (OR = 1.6, 95% confidence interval 1.2-2.2 for subjects drinking ≥ 9 drinks per day). Results did not change substantially when we evaluated associations by tobacco smoking status, or when we excluded participants who reported a history of pancreatitis, or participants whose data were based upon proxy responses. Further, no notable differences in pooled risk estimates emerged across strata of sex, age, race, study type, and study area. CONCLUSION: This collaborative-pooled analysis provides additional evidence for a positive association between heavy alcohol consumption and the risk of pancreatic cancer. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/21536662/full_citation L2 - https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mdr120 DB - PRIME DP - Unbound Medicine ER -