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Atopic dermatitis: a disease of altered skin barrier and immune dysregulation.

Abstract

Atopic dermatitis (AD) is an important chronic or relapsing inflammatory skin disease that often precedes asthma and allergic disorders. New insights into the genetics and pathophysiology of AD point to an important role of structural abnormalities in the epidermis as well as immune dysregulation not only for this skin disease but also for the development of asthma and allergies. Patients with AD have a unique predisposition to colonization or infection by microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. Measures directed at healing and protecting the skin barrier and addressing the immune dysregulation are essential in the treatment of patients with AD, and early intervention may improve outcomes for both the skin disease as well as other target organs.

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  • Authors+Show Affiliations

    ,

    Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.

    Source

    Immunological reviews 242:1 2011 Jul pg 233-46

    MeSH

    Adaptive Immunity
    Animals
    Anti-Inflammatory Agents
    Asthma
    Cytokines
    Dermatitis, Atopic
    Disease Models, Animal
    Epidermis
    Gene Expression Regulation
    Herpes Simplex
    Humans
    Immunity, Innate
    Intermediate Filament Proteins
    Keratinocytes
    Mice
    Mice, Transgenic
    Polymorphism, Genetic
    Pruritus
    Simplexvirus
    Staphylococcal Skin Infections
    Staphylococcus aureus
    T-Lymphocyte Subsets
    Tight Junctions
    Vitamin D

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    21682749

    Citation

    Boguniewicz, Mark, and Donald Y M. Leung. "Atopic Dermatitis: a Disease of Altered Skin Barrier and Immune Dysregulation." Immunological Reviews, vol. 242, no. 1, 2011, pp. 233-46.
    Boguniewicz M, Leung DY. Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. Immunol Rev. 2011;242(1):233-46.
    Boguniewicz, M., & Leung, D. Y. (2011). Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. Immunological Reviews, 242(1), pp. 233-46. doi:10.1111/j.1600-065X.2011.01027.x.
    Boguniewicz M, Leung DY. Atopic Dermatitis: a Disease of Altered Skin Barrier and Immune Dysregulation. Immunol Rev. 2011;242(1):233-46. PubMed PMID: 21682749.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. AU - Boguniewicz,Mark, AU - Leung,Donald Y M, PY - 2011/6/21/entrez PY - 2011/6/21/pubmed PY - 2011/10/4/medline SP - 233 EP - 46 JF - Immunological reviews JO - Immunol. Rev. VL - 242 IS - 1 N2 - Atopic dermatitis (AD) is an important chronic or relapsing inflammatory skin disease that often precedes asthma and allergic disorders. New insights into the genetics and pathophysiology of AD point to an important role of structural abnormalities in the epidermis as well as immune dysregulation not only for this skin disease but also for the development of asthma and allergies. Patients with AD have a unique predisposition to colonization or infection by microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. Measures directed at healing and protecting the skin barrier and addressing the immune dysregulation are essential in the treatment of patients with AD, and early intervention may improve outcomes for both the skin disease as well as other target organs. SN - 1600-065X UR - https://www.unboundmedicine.com/medline/citation/21682749/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-2896&date=2011&volume=242&spage=233 DB - PRIME DP - Unbound Medicine ER -