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Atopic dermatitis: a disease of altered skin barrier and immune dysregulation.
Immunol Rev 2011; 242(1):233-46IR

Abstract

Atopic dermatitis (AD) is an important chronic or relapsing inflammatory skin disease that often precedes asthma and allergic disorders. New insights into the genetics and pathophysiology of AD point to an important role of structural abnormalities in the epidermis as well as immune dysregulation not only for this skin disease but also for the development of asthma and allergies. Patients with AD have a unique predisposition to colonization or infection by microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. Measures directed at healing and protecting the skin barrier and addressing the immune dysregulation are essential in the treatment of patients with AD, and early intervention may improve outcomes for both the skin disease as well as other target organs.

Authors+Show Affiliations

Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

21682749

Citation

Boguniewicz, Mark, and Donald Y M. Leung. "Atopic Dermatitis: a Disease of Altered Skin Barrier and Immune Dysregulation." Immunological Reviews, vol. 242, no. 1, 2011, pp. 233-46.
Boguniewicz M, Leung DY. Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. Immunol Rev. 2011;242(1):233-46.
Boguniewicz, M., & Leung, D. Y. (2011). Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. Immunological Reviews, 242(1), pp. 233-46. doi:10.1111/j.1600-065X.2011.01027.x.
Boguniewicz M, Leung DY. Atopic Dermatitis: a Disease of Altered Skin Barrier and Immune Dysregulation. Immunol Rev. 2011;242(1):233-46. PubMed PMID: 21682749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. AU - Boguniewicz,Mark, AU - Leung,Donald Y M, PY - 2011/6/21/entrez PY - 2011/6/21/pubmed PY - 2011/10/4/medline SP - 233 EP - 46 JF - Immunological reviews JO - Immunol. Rev. VL - 242 IS - 1 N2 - Atopic dermatitis (AD) is an important chronic or relapsing inflammatory skin disease that often precedes asthma and allergic disorders. New insights into the genetics and pathophysiology of AD point to an important role of structural abnormalities in the epidermis as well as immune dysregulation not only for this skin disease but also for the development of asthma and allergies. Patients with AD have a unique predisposition to colonization or infection by microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. Measures directed at healing and protecting the skin barrier and addressing the immune dysregulation are essential in the treatment of patients with AD, and early intervention may improve outcomes for both the skin disease as well as other target organs. SN - 1600-065X UR - https://www.unboundmedicine.com/medline/citation/21682749/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-2896&date=2011&volume=242&spage=233 DB - PRIME DP - Unbound Medicine ER -