Citation
Jakszyn, Paula, et al. "Dietary Intake of Heme Iron and Risk of Gastric Cancer in the European Prospective Investigation Into Cancer and Nutrition Study." International Journal of Cancer, vol. 130, no. 11, 2012, pp. 2654-63.
Jakszyn P, Agudo A, Lujan-Barroso L, et al. Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study. Int J Cancer. 2012;130(11):2654-63.
Jakszyn, P., Agudo, A., Lujan-Barroso, L., Bueno-de-Mesquita, H. B., Jenab, M., Navarro, C., Palli, D., Boeing, H., Manjer, J., Numans, M. E., Igali, L., Boutron-Ruault, M. C., Clavel-Chapelon, F., Morois, S., Grioni, S., Panico, c., Tumino, R., Sacerdote, C., Quirós, J. R., ... González, C. A. (2012). Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study. International Journal of Cancer, 130(11), 2654-63. https://doi.org/10.1002/ijc.26263
Jakszyn P, et al. Dietary Intake of Heme Iron and Risk of Gastric Cancer in the European Prospective Investigation Into Cancer and Nutrition Study. Int J Cancer. 2012 Jun 1;130(11):2654-63. PubMed PMID: 21717452.
TY - JOUR
T1 - Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study.
AU - Jakszyn,Paula,
AU - Agudo,Antonio,
AU - Lujan-Barroso,Leila,
AU - Bueno-de-Mesquita,H Bas,
AU - Jenab,Mazda,
AU - Navarro,Carmen,
AU - Palli,Domenico,
AU - Boeing,Heiner,
AU - Manjer,Jonas,
AU - Numans,Mattijs E,
AU - Igali,Laszlo,
AU - Boutron-Ruault,Marie-Christine,
AU - Clavel-Chapelon,Françoise,
AU - Morois,Sophie,
AU - Grioni,Sara,
AU - Panico,cSalvatore,
AU - Tumino,Rosario,
AU - Sacerdote,Carlotta,
AU - Quirós,J Ramon,
AU - Molina-Montes,Esther,
AU - Huerta Castaño,Jose Ma,
AU - Barricarte,Aurelio,
AU - Amiano,Pilar,
AU - Khaw,Kay-Tee,
AU - Wareham,Nicholas,
AU - Allen,Naomi E,
AU - Key,Timothy J,
AU - Jeurnink,Suzanne M,
AU - Peeters,Petra H M,
AU - Bamia,Christina,
AU - Valanou,Elisabeth,
AU - Trichopoulou,Antonia,
AU - Kaaks,Rudolf,
AU - Lukanova,Annekatrin,
AU - Bergmann,Manuela M,
AU - Lindkvist,Björn,
AU - Stenling,Roger,
AU - Johansson,Ingegerd,
AU - Dahm,Christina C,
AU - Overvad,Kim,
AU - Olsen,Anja,
AU - Tjonneland,Anne,
AU - Skeie,Guri,
AU - Broderstad,Ann Ragnhild,
AU - Lund,Eiliv,
AU - Michaud,Dominique S,
AU - Mouw,Traci,
AU - Riboli,Elio,
AU - González,Carlos A,
Y1 - 2011/08/24/
PY - 2010/09/29/received
PY - 2011/05/05/accepted
PY - 2011/7/1/entrez
PY - 2011/7/1/pubmed
PY - 2012/5/12/medline
SP - 2654
EP - 63
JF - International journal of cancer
JO - Int J Cancer
VL - 130
IS - 11
N2 - Even though recent studies suggest that a high intake of heme iron is associated with several types of cancer, epidemiological studies in relation to gastric cancer (GC) are lacking. Our previous results show a positive association between red and processed meat and non cardia gastric cancer, especially in Helicobacter pylori infected subjects. The aim of the study is to investigate the association between heme iron intake and GC risk in the European prospective investigation into cancer and nutrition (EURGAST-EPIC). Dietary intake was assessed by validated center-specific questionnaires. Heme iron was calculated as a type-specific percentage of the total iron content in meat intake, derived from the literature. Antibodies of H. pylori infection and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control study within the cohort. The study included 481,419 individuals and 444 incident cases of GC that occurred during an average of 8.7 years of followup. We observed a statistically significant association between heme iron intake and GC risk (HR 1.13 95% CI: 1.01-1.26 for a doubling of intake) adjusted by sex, age, BMI, education level, tobacco smoking and energy intake. The positive association between heme iron and the risk of GC was statistically significant in subjects with plasma vitamin C <39 mmol/l only (log2 HR 1.54 95% CI (1.01-2.35). We found a positive association between heme iron intake and gastric cancer risk.
SN - 1097-0215
UR - https://www.unboundmedicine.com/medline/citation/21717452/full_citation
L2 - https://doi.org/10.1002/ijc.26263
DB - PRIME
DP - Unbound Medicine
ER -
