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Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study.
Int J Cancer 2012; 130(11):2654-63IJ

Abstract

Even though recent studies suggest that a high intake of heme iron is associated with several types of cancer, epidemiological studies in relation to gastric cancer (GC) are lacking. Our previous results show a positive association between red and processed meat and non cardia gastric cancer, especially in Helicobacter pylori infected subjects. The aim of the study is to investigate the association between heme iron intake and GC risk in the European prospective investigation into cancer and nutrition (EURGAST-EPIC). Dietary intake was assessed by validated center-specific questionnaires. Heme iron was calculated as a type-specific percentage of the total iron content in meat intake, derived from the literature. Antibodies of H. pylori infection and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control study within the cohort. The study included 481,419 individuals and 444 incident cases of GC that occurred during an average of 8.7 years of followup. We observed a statistically significant association between heme iron intake and GC risk (HR 1.13 95% CI: 1.01-1.26 for a doubling of intake) adjusted by sex, age, BMI, education level, tobacco smoking and energy intake. The positive association between heme iron and the risk of GC was statistically significant in subjects with plasma vitamin C <39 mmol/l only (log2 HR 1.54 95% CI (1.01-2.35). We found a positive association between heme iron intake and gastric cancer risk.

Authors+Show Affiliations

Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, (ICO-IDIBELL) Barcelona, Spain. paujak@iconcologia.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21717452

Citation

Jakszyn, Paula, et al. "Dietary Intake of Heme Iron and Risk of Gastric Cancer in the European Prospective Investigation Into Cancer and Nutrition Study." International Journal of Cancer, vol. 130, no. 11, 2012, pp. 2654-63.
Jakszyn P, Agudo A, Lujan-Barroso L, et al. Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study. Int J Cancer. 2012;130(11):2654-63.
Jakszyn, P., Agudo, A., Lujan-Barroso, L., Bueno-de-Mesquita, H. B., Jenab, M., Navarro, C., ... González, C. A. (2012). Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study. International Journal of Cancer, 130(11), pp. 2654-63. doi:10.1002/ijc.26263.
Jakszyn P, et al. Dietary Intake of Heme Iron and Risk of Gastric Cancer in the European Prospective Investigation Into Cancer and Nutrition Study. Int J Cancer. 2012 Jun 1;130(11):2654-63. PubMed PMID: 21717452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study. AU - Jakszyn,Paula, AU - Agudo,Antonio, AU - Lujan-Barroso,Leila, AU - Bueno-de-Mesquita,H Bas, AU - Jenab,Mazda, AU - Navarro,Carmen, AU - Palli,Domenico, AU - Boeing,Heiner, AU - Manjer,Jonas, AU - Numans,Mattijs E, AU - Igali,Laszlo, AU - Boutron-Ruault,Marie-Christine, AU - Clavel-Chapelon,Françoise, AU - Morois,Sophie, AU - Grioni,Sara, AU - Panico,cSalvatore, AU - Tumino,Rosario, AU - Sacerdote,Carlotta, AU - Quirós,J Ramon, AU - Molina-Montes,Esther, AU - Huerta Castaño,Jose Ma, AU - Barricarte,Aurelio, AU - Amiano,Pilar, AU - Khaw,Kay-Tee, AU - Wareham,Nicholas, AU - Allen,Naomi E, AU - Key,Timothy J, AU - Jeurnink,Suzanne M, AU - Peeters,Petra H M, AU - Bamia,Christina, AU - Valanou,Elisabeth, AU - Trichopoulou,Antonia, AU - Kaaks,Rudolf, AU - Lukanova,Annekatrin, AU - Bergmann,Manuela M, AU - Lindkvist,Björn, AU - Stenling,Roger, AU - Johansson,Ingegerd, AU - Dahm,Christina C, AU - Overvad,Kim, AU - Olsen,Anja, AU - Tjonneland,Anne, AU - Skeie,Guri, AU - Broderstad,Ann Ragnhild, AU - Lund,Eiliv, AU - Michaud,Dominique S, AU - Mouw,Traci, AU - Riboli,Elio, AU - González,Carlos A, Y1 - 2011/08/24/ PY - 2010/09/29/received PY - 2011/05/05/accepted PY - 2011/7/1/entrez PY - 2011/7/1/pubmed PY - 2012/5/12/medline SP - 2654 EP - 63 JF - International journal of cancer JO - Int. J. Cancer VL - 130 IS - 11 N2 - Even though recent studies suggest that a high intake of heme iron is associated with several types of cancer, epidemiological studies in relation to gastric cancer (GC) are lacking. Our previous results show a positive association between red and processed meat and non cardia gastric cancer, especially in Helicobacter pylori infected subjects. The aim of the study is to investigate the association between heme iron intake and GC risk in the European prospective investigation into cancer and nutrition (EURGAST-EPIC). Dietary intake was assessed by validated center-specific questionnaires. Heme iron was calculated as a type-specific percentage of the total iron content in meat intake, derived from the literature. Antibodies of H. pylori infection and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control study within the cohort. The study included 481,419 individuals and 444 incident cases of GC that occurred during an average of 8.7 years of followup. We observed a statistically significant association between heme iron intake and GC risk (HR 1.13 95% CI: 1.01-1.26 for a doubling of intake) adjusted by sex, age, BMI, education level, tobacco smoking and energy intake. The positive association between heme iron and the risk of GC was statistically significant in subjects with plasma vitamin C <39 mmol/l only (log2 HR 1.54 95% CI (1.01-2.35). We found a positive association between heme iron intake and gastric cancer risk. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/21717452/full_citation L2 - https://doi.org/10.1002/ijc.26263 DB - PRIME DP - Unbound Medicine ER -