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Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study.

Abstract

Even though recent studies suggest that a high intake of heme iron is associated with several types of cancer, epidemiological studies in relation to gastric cancer (GC) are lacking. Our previous results show a positive association between red and processed meat and non cardia gastric cancer, especially in Helicobacter pylori infected subjects. The aim of the study is to investigate the association between heme iron intake and GC risk in the European prospective investigation into cancer and nutrition (EURGAST-EPIC). Dietary intake was assessed by validated center-specific questionnaires. Heme iron was calculated as a type-specific percentage of the total iron content in meat intake, derived from the literature. Antibodies of H. pylori infection and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control study within the cohort. The study included 481,419 individuals and 444 incident cases of GC that occurred during an average of 8.7 years of followup. We observed a statistically significant association between heme iron intake and GC risk (HR 1.13 95% CI: 1.01-1.26 for a doubling of intake) adjusted by sex, age, BMI, education level, tobacco smoking and energy intake. The positive association between heme iron and the risk of GC was statistically significant in subjects with plasma vitamin C <39 mmol/l only (log2 HR 1.54 95% CI (1.01-2.35). We found a positive association between heme iron intake and gastric cancer risk.

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  • Authors+Show Affiliations

    ,

    Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, (ICO-IDIBELL) Barcelona, Spain. paujak@iconcologia.net

    , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

    Source

    International journal of cancer 130:11 2012 Jun 01 pg 2654-63

    MeSH

    Adult
    Aged
    Case-Control Studies
    Diet
    Europe
    Female
    Heme
    Humans
    Iron
    Male
    Meat
    Middle Aged
    Prospective Studies
    Risk
    Stomach Neoplasms

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21717452

    Citation

    Jakszyn, Paula, et al. "Dietary Intake of Heme Iron and Risk of Gastric Cancer in the European Prospective Investigation Into Cancer and Nutrition Study." International Journal of Cancer, vol. 130, no. 11, 2012, pp. 2654-63.
    Jakszyn P, Agudo A, Lujan-Barroso L, et al. Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study. Int J Cancer. 2012;130(11):2654-63.
    Jakszyn, P., Agudo, A., Lujan-Barroso, L., Bueno-de-Mesquita, H. B., Jenab, M., Navarro, C., ... González, C. A. (2012). Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study. International Journal of Cancer, 130(11), pp. 2654-63. doi:10.1002/ijc.26263.
    Jakszyn P, et al. Dietary Intake of Heme Iron and Risk of Gastric Cancer in the European Prospective Investigation Into Cancer and Nutrition Study. Int J Cancer. 2012 Jun 1;130(11):2654-63. PubMed PMID: 21717452.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study. AU - Jakszyn,Paula, AU - Agudo,Antonio, AU - Lujan-Barroso,Leila, AU - Bueno-de-Mesquita,H Bas, AU - Jenab,Mazda, AU - Navarro,Carmen, AU - Palli,Domenico, AU - Boeing,Heiner, AU - Manjer,Jonas, AU - Numans,Mattijs E, AU - Igali,Laszlo, AU - Boutron-Ruault,Marie-Christine, AU - Clavel-Chapelon,Françoise, AU - Morois,Sophie, AU - Grioni,Sara, AU - Panico,cSalvatore, AU - Tumino,Rosario, AU - Sacerdote,Carlotta, AU - Quirós,J Ramon, AU - Molina-Montes,Esther, AU - Huerta Castaño,Jose Ma, AU - Barricarte,Aurelio, AU - Amiano,Pilar, AU - Khaw,Kay-Tee, AU - Wareham,Nicholas, AU - Allen,Naomi E, AU - Key,Timothy J, AU - Jeurnink,Suzanne M, AU - Peeters,Petra H M, AU - Bamia,Christina, AU - Valanou,Elisabeth, AU - Trichopoulou,Antonia, AU - Kaaks,Rudolf, AU - Lukanova,Annekatrin, AU - Bergmann,Manuela M, AU - Lindkvist,Björn, AU - Stenling,Roger, AU - Johansson,Ingegerd, AU - Dahm,Christina C, AU - Overvad,Kim, AU - Olsen,Anja, AU - Tjonneland,Anne, AU - Skeie,Guri, AU - Broderstad,Ann Ragnhild, AU - Lund,Eiliv, AU - Michaud,Dominique S, AU - Mouw,Traci, AU - Riboli,Elio, AU - González,Carlos A, Y1 - 2011/08/24/ PY - 2010/09/29/received PY - 2011/05/05/accepted PY - 2011/7/1/entrez PY - 2011/7/1/pubmed PY - 2012/5/12/medline SP - 2654 EP - 63 JF - International journal of cancer JO - Int. J. Cancer VL - 130 IS - 11 N2 - Even though recent studies suggest that a high intake of heme iron is associated with several types of cancer, epidemiological studies in relation to gastric cancer (GC) are lacking. Our previous results show a positive association between red and processed meat and non cardia gastric cancer, especially in Helicobacter pylori infected subjects. The aim of the study is to investigate the association between heme iron intake and GC risk in the European prospective investigation into cancer and nutrition (EURGAST-EPIC). Dietary intake was assessed by validated center-specific questionnaires. Heme iron was calculated as a type-specific percentage of the total iron content in meat intake, derived from the literature. Antibodies of H. pylori infection and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control study within the cohort. The study included 481,419 individuals and 444 incident cases of GC that occurred during an average of 8.7 years of followup. We observed a statistically significant association between heme iron intake and GC risk (HR 1.13 95% CI: 1.01-1.26 for a doubling of intake) adjusted by sex, age, BMI, education level, tobacco smoking and energy intake. The positive association between heme iron and the risk of GC was statistically significant in subjects with plasma vitamin C <39 mmol/l only (log2 HR 1.54 95% CI (1.01-2.35). We found a positive association between heme iron intake and gastric cancer risk. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/21717452/full_citation L2 - https://doi.org/10.1002/ijc.26263 DB - PRIME DP - Unbound Medicine ER -