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Early-life risk factors and incidence of rhinitis: results from the European Community Respiratory Health Study--an international population-based cohort study.

Abstract

BACKGROUND

Rhinitis is an increasingly common condition with a heavy health care burden, but relatively little is known about its risk factors.

OBJECTIVE

To examine the association between early-life factors and the development of rhinitis in the European Community Respiratory Health Study (ECRHS).

METHODS

In 1992-1994, community-based samples of 20-44-year-old people were recruited from 48 centers in 22 countries. On average, 8.9 years later, 28 centers reinvestigated their samples. Onset of rhinitis was reported by 8486 participants in interviewer-led questionnaires. Cox regression was used to assess independent predictors of rhinitis at ages ≤5, 6-10, 11-20, and ≥21 years.

RESULTS

The crude lifelong incidence of rhinitis was 7.00/1000/year (men) and 7.95/1000/year (women) (P = .002). Women developed less rhinitis in later childhood (hazard ratios [HR], 0.63; 95% CI, 0.47-0.85) and more rhinitis in adulthood (HR, 1.36; 95% CI, 1.11-1.66) than did men. In atopic subjects, siblings were associated with lower risk of rhinitis throughout life (pooled HR, 0.94; 95% CI, 0.91-0.98 per 1 sibling). Early contact with children in the family or day care was associated with less incidence of rhinitis, predominantly before age 5 years (HR, 0.84; 95% CI, 0.72-0.99). Early childhood pets or growing up on a farm was associated with less incidence of rhinitis in adolescence (HR, 0.50; 95% CI, 0.37-0.68). Combining these factors showed evidence of a dose-response relationship (trend P = .0001).

CONCLUSIONS

Gender is a strong risk factor for rhinitis, with age patterns varying according to atopic status. Protective effects of early contact with children and animals were suggested for incident rhinitis, with risk patterns varying by age window and atopic status.

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  • Authors+Show Affiliations

    ,

    MEGA Epidemiology, University of Melbourne, Melbourne, Australia. mcmat@unimelb.edu.au

    , , , , , , , , , , ,

    Source

    MeSH

    Adult
    Child
    Child, Preschool
    Cohort Studies
    Environmental Exposure
    European Union
    Female
    Humans
    Male
    Pets
    Rhinitis
    Risk Factors
    Rural Population
    Sex Factors

    Pub Type(s)

    Clinical Trial
    Journal Article
    Multicenter Study
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21752439

    Citation

    Matheson, Melanie Claire, et al. "Early-life Risk Factors and Incidence of Rhinitis: Results From the European Community Respiratory Health Study--an International Population-based Cohort Study." The Journal of Allergy and Clinical Immunology, vol. 128, no. 4, 2011, pp. 816-823.e5.
    Matheson MC, Dharmage SC, Abramson MJ, et al. Early-life risk factors and incidence of rhinitis: results from the European Community Respiratory Health Study--an international population-based cohort study. J Allergy Clin Immunol. 2011;128(4):816-823.e5.
    Matheson, M. C., Dharmage, S. C., Abramson, M. J., Walters, E. H., Sunyer, J., de Marco, R., ... Svanes, C. (2011). Early-life risk factors and incidence of rhinitis: results from the European Community Respiratory Health Study--an international population-based cohort study. The Journal of Allergy and Clinical Immunology, 128(4), pp. 816-823.e5. doi:10.1016/j.jaci.2011.05.039.
    Matheson MC, et al. Early-life Risk Factors and Incidence of Rhinitis: Results From the European Community Respiratory Health Study--an International Population-based Cohort Study. J Allergy Clin Immunol. 2011;128(4):816-823.e5. PubMed PMID: 21752439.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Early-life risk factors and incidence of rhinitis: results from the European Community Respiratory Health Study--an international population-based cohort study. AU - Matheson,Melanie Claire, AU - Dharmage,Shyamali Chandrika, AU - Abramson,Michael John, AU - Walters,Eugene Haydn, AU - Sunyer,Jordi, AU - de Marco,Roberto, AU - Leynaert,Benedicte, AU - Heinrich,Joachim, AU - Jarvis,Deborah, AU - Norbäck,Dan, AU - Raherison,Chantal, AU - Wjst,Matthias, AU - Svanes,Cecilie, Y1 - 2011/07/12/ PY - 2010/09/17/received PY - 2011/05/24/revised PY - 2011/05/27/accepted PY - 2011/7/15/entrez PY - 2011/7/15/pubmed PY - 2011/12/13/medline SP - 816 EP - 823.e5 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 128 IS - 4 N2 - BACKGROUND: Rhinitis is an increasingly common condition with a heavy health care burden, but relatively little is known about its risk factors. OBJECTIVE: To examine the association between early-life factors and the development of rhinitis in the European Community Respiratory Health Study (ECRHS). METHODS: In 1992-1994, community-based samples of 20-44-year-old people were recruited from 48 centers in 22 countries. On average, 8.9 years later, 28 centers reinvestigated their samples. Onset of rhinitis was reported by 8486 participants in interviewer-led questionnaires. Cox regression was used to assess independent predictors of rhinitis at ages ≤5, 6-10, 11-20, and ≥21 years. RESULTS: The crude lifelong incidence of rhinitis was 7.00/1000/year (men) and 7.95/1000/year (women) (P = .002). Women developed less rhinitis in later childhood (hazard ratios [HR], 0.63; 95% CI, 0.47-0.85) and more rhinitis in adulthood (HR, 1.36; 95% CI, 1.11-1.66) than did men. In atopic subjects, siblings were associated with lower risk of rhinitis throughout life (pooled HR, 0.94; 95% CI, 0.91-0.98 per 1 sibling). Early contact with children in the family or day care was associated with less incidence of rhinitis, predominantly before age 5 years (HR, 0.84; 95% CI, 0.72-0.99). Early childhood pets or growing up on a farm was associated with less incidence of rhinitis in adolescence (HR, 0.50; 95% CI, 0.37-0.68). Combining these factors showed evidence of a dose-response relationship (trend P = .0001). CONCLUSIONS: Gender is a strong risk factor for rhinitis, with age patterns varying according to atopic status. Protective effects of early contact with children and animals were suggested for incident rhinitis, with risk patterns varying by age window and atopic status. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/21752439/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(11)00865-7 DB - PRIME DP - Unbound Medicine ER -