Type your tag names separated by a space and hit enter

Serum selenium, genetic variation in selenoenzymes, and risk of colorectal cancer: primary analysis from the Women's Health Initiative Observational Study and meta-analysis.

Abstract

BACKGROUND

Selenium may prevent colorectal cancer. However, several previous studies are small and few investigated the association between selenium and colorectal cancer among women whose selenium metabolism may differ from men. Furthermore, genetic variants in selenoenzymes may be associated with colorectal cancer risk.

METHODS

This nested case-control study investigated whether serum selenium concentration and genetic variants in five selenoenzymes (glutathione peroxidase 1-4 and selenoprotein P) were associated with colorectal cancer risk in 804 colorectal cancer cases and 805 matched controls from the Women's Health Initiative (WHI) Observational Study. A meta-analysis was conducted to compare the WHI result with previous studies including 12 observational studies and two clinical trials on selenium.

RESULTS

Within the WHI, selenium concentrations were relatively high (mean = 135.6 μg/L) and were not associated with colorectal cancer risk (P(trend) = 0.10); the adjusted OR comparing the fifth with first quintile was 1.26 (95% CI, 0.91-1.73). Moreover, genetic variants in selenoenzymes were not significantly associated with colorectal cancer risk. Consistent with the finding in WHI, our meta-analysis showed no association between selenium and colorectal tumor risk in women (OR = 0.97; 95% CI, 0.79-1.18) comparing the highest quantile with the lowest); however, in men, there was a significant inverse association (OR = 0.68; 95% CI, 0.57-0.82) (P = 0.01).

CONCLUSION

Consistent with previous studies, we observed no protective effect of selenium on colorectal cancer among women.

IMPACT

Our analyses suggest that a population with relatively high selenium concentrations, especially women, would not benefit from increasing selenium intake.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.

    , , , , , , , , , , , , , ,

    Source

    MeSH

    Aged
    Case-Control Studies
    Colorectal Neoplasms
    Female
    Genetic Predisposition to Disease
    Glutathione Peroxidase
    Humans
    Male
    Middle Aged
    Risk Factors
    Selenium
    Selenoprotein P
    United States
    Women's Health

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    21765007

    Citation

    Takata, Yumie, et al. "Serum Selenium, Genetic Variation in Selenoenzymes, and Risk of Colorectal Cancer: Primary Analysis From the Women's Health Initiative Observational Study and Meta-analysis." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 20, no. 9, 2011, pp. 1822-30.
    Takata Y, Kristal AR, King IB, et al. Serum selenium, genetic variation in selenoenzymes, and risk of colorectal cancer: primary analysis from the Women's Health Initiative Observational Study and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2011;20(9):1822-30.
    Takata, Y., Kristal, A. R., King, I. B., Song, X., Diamond, A. M., Foster, C. B., ... Peters, U. (2011). Serum selenium, genetic variation in selenoenzymes, and risk of colorectal cancer: primary analysis from the Women's Health Initiative Observational Study and meta-analysis. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 20(9), pp. 1822-30. doi:10.1158/1055-9965.EPI-11-0364.
    Takata Y, et al. Serum Selenium, Genetic Variation in Selenoenzymes, and Risk of Colorectal Cancer: Primary Analysis From the Women's Health Initiative Observational Study and Meta-analysis. Cancer Epidemiol Biomarkers Prev. 2011;20(9):1822-30. PubMed PMID: 21765007.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum selenium, genetic variation in selenoenzymes, and risk of colorectal cancer: primary analysis from the Women's Health Initiative Observational Study and meta-analysis. AU - Takata,Yumie, AU - Kristal,Alan R, AU - King,Irena B, AU - Song,Xiaoling, AU - Diamond,Alan M, AU - Foster,Charles B, AU - Hutter,Carolyn M, AU - Hsu,Li, AU - Duggan,David J, AU - Langer,Robert D, AU - Petrovitch,Helen, AU - Shikany,James M, AU - Vaughan,Thomas L, AU - Lampe,Johanna W, AU - Prentice,Ross L, AU - Peters,Ulrike, Y1 - 2011/07/15/ PY - 2011/7/19/entrez PY - 2011/7/19/pubmed PY - 2012/3/23/medline SP - 1822 EP - 30 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 20 IS - 9 N2 - BACKGROUND: Selenium may prevent colorectal cancer. However, several previous studies are small and few investigated the association between selenium and colorectal cancer among women whose selenium metabolism may differ from men. Furthermore, genetic variants in selenoenzymes may be associated with colorectal cancer risk. METHODS: This nested case-control study investigated whether serum selenium concentration and genetic variants in five selenoenzymes (glutathione peroxidase 1-4 and selenoprotein P) were associated with colorectal cancer risk in 804 colorectal cancer cases and 805 matched controls from the Women's Health Initiative (WHI) Observational Study. A meta-analysis was conducted to compare the WHI result with previous studies including 12 observational studies and two clinical trials on selenium. RESULTS: Within the WHI, selenium concentrations were relatively high (mean = 135.6 μg/L) and were not associated with colorectal cancer risk (P(trend) = 0.10); the adjusted OR comparing the fifth with first quintile was 1.26 (95% CI, 0.91-1.73). Moreover, genetic variants in selenoenzymes were not significantly associated with colorectal cancer risk. Consistent with the finding in WHI, our meta-analysis showed no association between selenium and colorectal tumor risk in women (OR = 0.97; 95% CI, 0.79-1.18) comparing the highest quantile with the lowest); however, in men, there was a significant inverse association (OR = 0.68; 95% CI, 0.57-0.82) (P = 0.01). CONCLUSION: Consistent with previous studies, we observed no protective effect of selenium on colorectal cancer among women. IMPACT: Our analyses suggest that a population with relatively high selenium concentrations, especially women, would not benefit from increasing selenium intake. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/21765007/full_citation L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=21765007 DB - PRIME DP - Unbound Medicine ER -