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Diet and risk of diverticular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians.

Abstract

OBJECTIVE

To examine the associations of a vegetarian diet and dietary fibre intake with risk of diverticular disease.

DESIGN

Prospective cohort study.

SETTING

The EPIC-Oxford study, a cohort of mainly health conscious participants recruited from around the United Kingdom.

PARTICIPANTS

47,033 men and women living in England or Scotland of whom 15,459 (33%) reported consuming a vegetarian diet.

MAIN OUTCOME MEASURES

Diet group was assessed at baseline; intake of dietary fibre was estimated from a 130 item validated food frequency questionnaire. Cases of diverticular disease were identified through linkage with hospital records and death certificates. Hazard ratios and 95% confidence intervals for the risk of diverticular disease by diet group and fifths of intake of dietary fibre were estimated with multivariate Cox proportional hazards regression models.

RESULTS

After a mean follow-up time of 11.6 years, there were 812 cases of diverticular disease (806 admissions to hospital and six deaths). After adjustment for confounding variables, vegetarians had a 31% lower risk (relative risk 0.69, 95% confidence interval 0.55 to 0.86) of diverticular disease compared with meat eaters. The cumulative probability of admission to hospital or death from diverticular disease between the ages of 50 and 70 for meat eaters was 4.4% compared with 3.0% for vegetarians. There was also an inverse association with dietary fibre intake; participants in the highest fifth (≥25.5 g/day for women and ≥26.1 g/day for men) had a 41% lower risk (0.59, 0.46 to 0.78; P<0.001 trend) compared with those in the lowest fifth (<14 g/day for both women and men). After mutual adjustment, both a vegetarian diet and a higher intake of fibre were significantly associated with a lower risk of diverticular disease.

CONCLUSIONS

Consuming a vegetarian diet and a high intake of dietary fibre were both associated with a lower risk of admission to hospital or death from diverticular disease.

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  • Authors+Show Affiliations

    ,

    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, UK. francesca.crowe@ceu.ox.ac.uk

    , ,

    Source

    BMJ (Clinical research ed.) 343: 2011 Jul 19 pg d4131

    MeSH

    Adult
    Age Distribution
    Aged, 80 and over
    Body Mass Index
    Diet
    Diet, Vegetarian
    Dietary Fiber
    Diverticulum
    Female
    Humans
    Intestinal Diseases
    Intestine, Large
    Intestine, Small
    Life Style
    Male
    Middle Aged
    Prospective Studies
    Risk Factors
    Sex Distribution
    United Kingdom
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21771850

    Citation

    Crowe, Francesca L., et al. "Diet and Risk of Diverticular Disease in Oxford Cohort of European Prospective Investigation Into Cancer and Nutrition (EPIC): Prospective Study of British Vegetarians and Non-vegetarians." BMJ (Clinical Research Ed.), vol. 343, 2011, pp. d4131.
    Crowe FL, Appleby PN, Allen NE, et al. Diet and risk of diverticular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians. BMJ. 2011;343:d4131.
    Crowe, F. L., Appleby, P. N., Allen, N. E., & Key, T. J. (2011). Diet and risk of diverticular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians. BMJ (Clinical Research Ed.), 343, pp. d4131. doi:10.1136/bmj.d4131.
    Crowe FL, et al. Diet and Risk of Diverticular Disease in Oxford Cohort of European Prospective Investigation Into Cancer and Nutrition (EPIC): Prospective Study of British Vegetarians and Non-vegetarians. BMJ. 2011 Jul 19;343:d4131. PubMed PMID: 21771850.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Diet and risk of diverticular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians. AU - Crowe,Francesca L, AU - Appleby,Paul N, AU - Allen,Naomi E, AU - Key,Timothy J, Y1 - 2011/07/19/ PY - 2011/7/21/entrez PY - 2011/7/21/pubmed PY - 2012/3/1/medline SP - d4131 EP - d4131 JF - BMJ (Clinical research ed.) JO - BMJ VL - 343 N2 - OBJECTIVE: To examine the associations of a vegetarian diet and dietary fibre intake with risk of diverticular disease. DESIGN: Prospective cohort study. SETTING: The EPIC-Oxford study, a cohort of mainly health conscious participants recruited from around the United Kingdom. PARTICIPANTS: 47,033 men and women living in England or Scotland of whom 15,459 (33%) reported consuming a vegetarian diet. MAIN OUTCOME MEASURES: Diet group was assessed at baseline; intake of dietary fibre was estimated from a 130 item validated food frequency questionnaire. Cases of diverticular disease were identified through linkage with hospital records and death certificates. Hazard ratios and 95% confidence intervals for the risk of diverticular disease by diet group and fifths of intake of dietary fibre were estimated with multivariate Cox proportional hazards regression models. RESULTS: After a mean follow-up time of 11.6 years, there were 812 cases of diverticular disease (806 admissions to hospital and six deaths). After adjustment for confounding variables, vegetarians had a 31% lower risk (relative risk 0.69, 95% confidence interval 0.55 to 0.86) of diverticular disease compared with meat eaters. The cumulative probability of admission to hospital or death from diverticular disease between the ages of 50 and 70 for meat eaters was 4.4% compared with 3.0% for vegetarians. There was also an inverse association with dietary fibre intake; participants in the highest fifth (≥25.5 g/day for women and ≥26.1 g/day for men) had a 41% lower risk (0.59, 0.46 to 0.78; P<0.001 trend) compared with those in the lowest fifth (<14 g/day for both women and men). After mutual adjustment, both a vegetarian diet and a higher intake of fibre were significantly associated with a lower risk of diverticular disease. CONCLUSIONS: Consuming a vegetarian diet and a high intake of dietary fibre were both associated with a lower risk of admission to hospital or death from diverticular disease. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/21771850/full_citation L2 - http://www.bmj.com/cgi/pmidlookup?view=long&amp;pmid=21771850 DB - PRIME DP - Unbound Medicine ER -