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Randomised controlled trial of food elimination diet based on IgG antibodies for the prevention of migraine like headaches.

Abstract

BACKGROUND

Research suggests that food intolerance may be a precipitating factor for migraine like headaches.

AIM

To evaluate the effectiveness of the ELISA (Enzyme Linked Immuno-Sorbent Assay) Test and subsequent dietary elimination advice for the prevention of migraine like headaches.

DESIGN

Randomised controlled trial.

SETTING

Community based volunteers in the UK.

PARTICIPANTS

Volunteers who met the inclusion criteria for migraine like headaches and had one or more food intolerance were included in the study. Participants received either a true diet (n = 84) or a sham diet (n = 83) sheet. Participants were advised to remove the intolerant foods from their diet for 12 weeks.

MAIN OUTCOME MEASURES

Number of headache days over a 12 week period (item A MIDAS questionnaire). Other measures includes the total MIDAS score and total HIT-6 score.

RESULTS

The results indicated a small decrease in the number of migraine like headaches over 12 weeks, although this difference was not statistically significant (IRR 1.15 95% CI 0.94 to 1.41, p = 0.18). At the 4 week assessment, use of the ELISA test with subsequent diet elimination advice significantly reduced the number of migraine like headaches (IRR 1.23 95%CI 1.01 to 1.50, p = 0.04). The disability and impact on daily life of migraines were not significantly different between the true and sham diet groups.

CONCLUSIONS

Use of the ELISA test with subsequent diet elimination advice did not reduce the disability or impact on daily life of migraine like headaches or the number of migraine like headaches at 12 weeks but it did significantly reduce the number of migraine like headaches at 4 weeks.

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  • Authors+Show Affiliations

    ,

    York Trials Unit, Department of Health Sciences, University of York, York, YO10 5DD, UK. natasha.mitchell@york.ac.uk

    , , , , ,

    Source

    Nutrition journal 10: 2011 Aug 11 pg 85

    MeSH

    Adult
    Diet
    Disability Evaluation
    Enzyme-Linked Immunosorbent Assay
    Female
    Food Hypersensitivity
    Headache
    Humans
    Immunoglobulin G
    Male
    Middle Aged
    Migraine Disorders
    Pain Measurement
    Single-Blind Method
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21835022

    Citation

    Mitchell, Natasha, et al. "Randomised Controlled Trial of Food Elimination Diet Based On IgG Antibodies for the Prevention of Migraine Like Headaches." Nutrition Journal, vol. 10, 2011, p. 85.
    Mitchell N, Hewitt CE, Jayakody S, et al. Randomised controlled trial of food elimination diet based on IgG antibodies for the prevention of migraine like headaches. Nutr J. 2011;10:85.
    Mitchell, N., Hewitt, C. E., Jayakody, S., Islam, M., Adamson, J., Watt, I., & Torgerson, D. J. (2011). Randomised controlled trial of food elimination diet based on IgG antibodies for the prevention of migraine like headaches. Nutrition Journal, 10, p. 85. doi:10.1186/1475-2891-10-85.
    Mitchell N, et al. Randomised Controlled Trial of Food Elimination Diet Based On IgG Antibodies for the Prevention of Migraine Like Headaches. Nutr J. 2011 Aug 11;10:85. PubMed PMID: 21835022.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Randomised controlled trial of food elimination diet based on IgG antibodies for the prevention of migraine like headaches. AU - Mitchell,Natasha, AU - Hewitt,Catherine E, AU - Jayakody,Shalmini, AU - Islam,Muhammad, AU - Adamson,Joy, AU - Watt,Ian, AU - Torgerson,David J, Y1 - 2011/08/11/ PY - 2011/05/04/received PY - 2011/08/11/accepted PY - 2011/8/13/entrez PY - 2011/8/13/pubmed PY - 2011/12/13/medline SP - 85 EP - 85 JF - Nutrition journal JO - Nutr J VL - 10 N2 - BACKGROUND: Research suggests that food intolerance may be a precipitating factor for migraine like headaches. AIM: To evaluate the effectiveness of the ELISA (Enzyme Linked Immuno-Sorbent Assay) Test and subsequent dietary elimination advice for the prevention of migraine like headaches. DESIGN: Randomised controlled trial. SETTING: Community based volunteers in the UK. PARTICIPANTS: Volunteers who met the inclusion criteria for migraine like headaches and had one or more food intolerance were included in the study. Participants received either a true diet (n = 84) or a sham diet (n = 83) sheet. Participants were advised to remove the intolerant foods from their diet for 12 weeks. MAIN OUTCOME MEASURES: Number of headache days over a 12 week period (item A MIDAS questionnaire). Other measures includes the total MIDAS score and total HIT-6 score. RESULTS: The results indicated a small decrease in the number of migraine like headaches over 12 weeks, although this difference was not statistically significant (IRR 1.15 95% CI 0.94 to 1.41, p = 0.18). At the 4 week assessment, use of the ELISA test with subsequent diet elimination advice significantly reduced the number of migraine like headaches (IRR 1.23 95%CI 1.01 to 1.50, p = 0.04). The disability and impact on daily life of migraines were not significantly different between the true and sham diet groups. CONCLUSIONS: Use of the ELISA test with subsequent diet elimination advice did not reduce the disability or impact on daily life of migraine like headaches or the number of migraine like headaches at 12 weeks but it did significantly reduce the number of migraine like headaches at 4 weeks. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/21835022/full_citation L2 - https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-10-85 DB - PRIME DP - Unbound Medicine ER -