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Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies.
Ann Oncol 2012; 23(4):843-52AO

Abstract

BACKGROUND

Questions remain about the shape of the dose-response relationship between body mass index (BMI) and pancreatic cancer risk, possible confounding by smoking, and differences by gender or geographic location. Whether abdominal obesity increases risk is unclear.

METHODS

We conducted a systematic review and meta-analysis of prospective studies of the association between BMI, abdominal fatness and pancreatic cancer risk and searched PubMed and several other databases up to January 2011. Summary relative risks (RRs) were calculated using a random-effects model.

RESULTS

Twenty-three prospective studies of BMI and pancreatic cancer risk with 9504 cases were included. The summary RR for a 5-unit increment was 1.10 [95% confidence interval (CI) 1.07-1.14, I(2) = 19%] and results were similar when stratified by gender and geographic location. There was evidence of a non-linear association, P(non-linearity) = 0.005; however, among nonsmokers, there was increased risk even within the 'normal' BMI range. The summary RR for a 10-cm increase in waist circumference was 1.11 (95% CI 1.05-1.18, I(2) = 0%) and for a 0.1-unit increment in waist-to-hip ratio was 1.19 (95% CI 1.09-1.31, I(2) = 11%).

CONCLUSIONS

Both general and abdominal fatness increases pancreatic cancer risk. Among nonsmokers, risk increases even among persons within the normal BMI range.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Imperial College London, London, UK. d.aune@imperial.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

21890910

Citation

Aune, D, et al. "Body Mass Index, Abdominal Fatness and Pancreatic Cancer Risk: a Systematic Review and Non-linear Dose-response Meta-analysis of Prospective Studies." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 23, no. 4, 2012, pp. 843-52.
Aune D, Greenwood DC, Chan DS, et al. Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies. Ann Oncol. 2012;23(4):843-52.
Aune, D., Greenwood, D. C., Chan, D. S., Vieira, R., Vieira, A. R., Navarro Rosenblatt, D. A., ... Norat, T. (2012). Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 23(4), pp. 843-52. doi:10.1093/annonc/mdr398.
Aune D, et al. Body Mass Index, Abdominal Fatness and Pancreatic Cancer Risk: a Systematic Review and Non-linear Dose-response Meta-analysis of Prospective Studies. Ann Oncol. 2012;23(4):843-52. PubMed PMID: 21890910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies. AU - Aune,D, AU - Greenwood,D C, AU - Chan,D S M, AU - Vieira,R, AU - Vieira,A R, AU - Navarro Rosenblatt,D A, AU - Cade,J E, AU - Burley,V J, AU - Norat,T, Y1 - 2011/09/02/ PY - 2011/9/6/entrez PY - 2011/9/6/pubmed PY - 2012/7/14/medline SP - 843 EP - 52 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 23 IS - 4 N2 - BACKGROUND: Questions remain about the shape of the dose-response relationship between body mass index (BMI) and pancreatic cancer risk, possible confounding by smoking, and differences by gender or geographic location. Whether abdominal obesity increases risk is unclear. METHODS: We conducted a systematic review and meta-analysis of prospective studies of the association between BMI, abdominal fatness and pancreatic cancer risk and searched PubMed and several other databases up to January 2011. Summary relative risks (RRs) were calculated using a random-effects model. RESULTS: Twenty-three prospective studies of BMI and pancreatic cancer risk with 9504 cases were included. The summary RR for a 5-unit increment was 1.10 [95% confidence interval (CI) 1.07-1.14, I(2) = 19%] and results were similar when stratified by gender and geographic location. There was evidence of a non-linear association, P(non-linearity) = 0.005; however, among nonsmokers, there was increased risk even within the 'normal' BMI range. The summary RR for a 10-cm increase in waist circumference was 1.11 (95% CI 1.05-1.18, I(2) = 0%) and for a 0.1-unit increment in waist-to-hip ratio was 1.19 (95% CI 1.09-1.31, I(2) = 11%). CONCLUSIONS: Both general and abdominal fatness increases pancreatic cancer risk. Among nonsmokers, risk increases even among persons within the normal BMI range. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/21890910/full_citation L2 - https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mdr398 DB - PRIME DP - Unbound Medicine ER -