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Efficacy and safety of zinc supplementation for adults, children and pregnant women with HIV infection: systematic review.

Abstract

OBJECTIVES

To determine the efficacy and safety of zinc supplementary in children, adults and pregnant women with HIV infection.

METHODS

We conducted a comprehensive search in Medline, Embase, the Cochrane Library, CBM, VIP and CNKI. Only randomized controlled trials conducted subsequent to the introduction of zinc supplementation were included in this systematic review. Two reviewers assessed and extracted data for analysis.

RESULTS

Six trials with a total of 1009 participants were included. The findings in this review suggested a benefit of zinc supplementation in reducing opportunistic infection for both adults and children with HIV infection. In terms of increase in zinc level and CD4 counts, however, only adults with HIV infection benefited. For other outcomes, such as viral load, mortality, mother-to-child transmission of HIV and foetal outcomes, zinc supplementation conferred no benefit over placebo. No adverse event related to zinc supplementation was found in all the included trials.

CONCLUSION

Based on the current evidence, zinc supplementation seems to be beneficial in adult patients with HIV infection in some aspects. More research is needed in children and pregnant women. The influence of zinc dose, duration and usage of antiretroviral medicine also requires further investigation.

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  • Authors+Show Affiliations

    ,

    Department of Pharmacy, West China Second University Hospital, Sichuan, China.

    Source

    MeSH

    AIDS-Related Opportunistic Infections
    Adult
    CD4 Lymphocyte Count
    Child, Preschool
    Diarrhea
    Dietary Supplements
    Female
    HIV Infections
    Humans
    Infant
    Infectious Disease Transmission, Vertical
    Labyrinth Diseases
    Male
    Middle Aged
    Pneumonia
    Pregnancy
    Pregnancy Complications, Infectious
    Pregnancy Outcome
    Randomized Controlled Trials as Topic
    Respiratory Tract Infections
    Trace Elements
    Treatment Outcome
    Viral Load
    Young Adult
    Zinc

    Pub Type(s)

    Journal Article
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    21895892

    Citation

    Zeng, Linan, and Lingli Zhang. "Efficacy and Safety of Zinc Supplementation for Adults, Children and Pregnant Women With HIV Infection: Systematic Review." Tropical Medicine & International Health : TM & IH, vol. 16, no. 12, 2011, pp. 1474-82.
    Zeng L, Zhang L. Efficacy and safety of zinc supplementation for adults, children and pregnant women with HIV infection: systematic review. Trop Med Int Health. 2011;16(12):1474-82.
    Zeng, L., & Zhang, L. (2011). Efficacy and safety of zinc supplementation for adults, children and pregnant women with HIV infection: systematic review. Tropical Medicine & International Health : TM & IH, 16(12), pp. 1474-82. doi:10.1111/j.1365-3156.2011.02871.x.
    Zeng L, Zhang L. Efficacy and Safety of Zinc Supplementation for Adults, Children and Pregnant Women With HIV Infection: Systematic Review. Trop Med Int Health. 2011;16(12):1474-82. PubMed PMID: 21895892.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Efficacy and safety of zinc supplementation for adults, children and pregnant women with HIV infection: systematic review. AU - Zeng,Linan, AU - Zhang,Lingli, Y1 - 2011/09/07/ PY - 2011/9/8/entrez PY - 2011/9/8/pubmed PY - 2012/11/14/medline SP - 1474 EP - 82 JF - Tropical medicine & international health : TM & IH JO - Trop. Med. Int. Health VL - 16 IS - 12 N2 - OBJECTIVES: To determine the efficacy and safety of zinc supplementary in children, adults and pregnant women with HIV infection. METHODS: We conducted a comprehensive search in Medline, Embase, the Cochrane Library, CBM, VIP and CNKI. Only randomized controlled trials conducted subsequent to the introduction of zinc supplementation were included in this systematic review. Two reviewers assessed and extracted data for analysis. RESULTS: Six trials with a total of 1009 participants were included. The findings in this review suggested a benefit of zinc supplementation in reducing opportunistic infection for both adults and children with HIV infection. In terms of increase in zinc level and CD4 counts, however, only adults with HIV infection benefited. For other outcomes, such as viral load, mortality, mother-to-child transmission of HIV and foetal outcomes, zinc supplementation conferred no benefit over placebo. No adverse event related to zinc supplementation was found in all the included trials. CONCLUSION: Based on the current evidence, zinc supplementation seems to be beneficial in adult patients with HIV infection in some aspects. More research is needed in children and pregnant women. The influence of zinc dose, duration and usage of antiretroviral medicine also requires further investigation. SN - 1365-3156 UR - https://www.unboundmedicine.com/medline/citation/21895892/full_citation L2 - https://doi.org/10.1111/j.1365-3156.2011.02871.x DB - PRIME DP - Unbound Medicine ER -