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Egg, red meat, and poultry intake and risk of lethal prostate cancer in the prostate-specific antigen-era: incidence and survival.

Abstract

Red and processed meat may increase risk of advanced prostate cancer. Data on postdiagnostic diet and prostate cancer are sparse, but postdiagnostic intake of poultry with skin and eggs may increase risk of disease progression. Therefore, we prospectively examined total, unprocessed, and processed red meat, poultry, and eggs in relation to risk of lethal prostate cancer (e.g., men without cancer at baseline who developed distant organ metastases or died from prostate cancer during follow-up) among 27,607 men followed from 1994 to 2008. We also conducted a case-only survival analysis to examine postdiagnostic consumption of these foods and risk of lethal prostate cancer among the 3,127 men initially diagnosed with nonmetastatic prostate cancer during follow-up. In the incidence analysis, we observed 199 events during 306,715 person-years. Men who consumed 2.5 or more eggs per week had an 81% increased risk of lethal prostate cancer compared with men who consumed less than 0.5 eggs per week (HR: 1.81; 95% CI: 1.13-2.89; P(trend): 0.01). In the case-only survival analysis, we observed 123 events during 19,354 person-years. There were suggestive, but not statistically significant, positive associations between postdiagnostic poultry (HR ≥ 3.5 vs. <1.5 servings per week: 1.69; 95% CI: 0.96-2.99; P(trend): 0.07) and postdiagnostic processed red meat (HR ≥ 3 vs. <0.5 servings per week: 1.45; 95% CI: 0.73-2.87; P(trend): 0.08) and risk of progression of localized prostate cancer to lethal disease. In conclusion, consumption of eggs may increase risk of developing a lethal form of prostate cancer among healthy men.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. richmane@urology.ucsf.edu

    , , ,

    Source

    MeSH

    Adult
    Aged
    Animals
    Diet
    Eggs
    Follow-Up Studies
    Humans
    Incidence
    Male
    Meat
    Middle Aged
    Poultry
    Prospective Studies
    Prostate-Specific Antigen
    Prostatic Neoplasms
    Risk Assessment
    Risk Factors
    Survival Rate

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    21930800

    Citation

    Richman, Erin L., et al. "Egg, Red Meat, and Poultry Intake and Risk of Lethal Prostate Cancer in the Prostate-specific Antigen-era: Incidence and Survival." Cancer Prevention Research (Philadelphia, Pa.), vol. 4, no. 12, 2011, pp. 2110-21.
    Richman EL, Kenfield SA, Stampfer MJ, et al. Egg, red meat, and poultry intake and risk of lethal prostate cancer in the prostate-specific antigen-era: incidence and survival. Cancer Prev Res (Phila). 2011;4(12):2110-21.
    Richman, E. L., Kenfield, S. A., Stampfer, M. J., Giovannucci, E. L., & Chan, J. M. (2011). Egg, red meat, and poultry intake and risk of lethal prostate cancer in the prostate-specific antigen-era: incidence and survival. Cancer Prevention Research (Philadelphia, Pa.), 4(12), pp. 2110-21. doi:10.1158/1940-6207.CAPR-11-0354.
    Richman EL, et al. Egg, Red Meat, and Poultry Intake and Risk of Lethal Prostate Cancer in the Prostate-specific Antigen-era: Incidence and Survival. Cancer Prev Res (Phila). 2011;4(12):2110-21. PubMed PMID: 21930800.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Egg, red meat, and poultry intake and risk of lethal prostate cancer in the prostate-specific antigen-era: incidence and survival. AU - Richman,Erin L, AU - Kenfield,Stacey A, AU - Stampfer,Meir J, AU - Giovannucci,Edward L, AU - Chan,June M, Y1 - 2011/09/19/ PY - 2011/9/21/entrez PY - 2011/9/21/pubmed PY - 2012/4/4/medline SP - 2110 EP - 21 JF - Cancer prevention research (Philadelphia, Pa.) JO - Cancer Prev Res (Phila) VL - 4 IS - 12 N2 - Red and processed meat may increase risk of advanced prostate cancer. Data on postdiagnostic diet and prostate cancer are sparse, but postdiagnostic intake of poultry with skin and eggs may increase risk of disease progression. Therefore, we prospectively examined total, unprocessed, and processed red meat, poultry, and eggs in relation to risk of lethal prostate cancer (e.g., men without cancer at baseline who developed distant organ metastases or died from prostate cancer during follow-up) among 27,607 men followed from 1994 to 2008. We also conducted a case-only survival analysis to examine postdiagnostic consumption of these foods and risk of lethal prostate cancer among the 3,127 men initially diagnosed with nonmetastatic prostate cancer during follow-up. In the incidence analysis, we observed 199 events during 306,715 person-years. Men who consumed 2.5 or more eggs per week had an 81% increased risk of lethal prostate cancer compared with men who consumed less than 0.5 eggs per week (HR: 1.81; 95% CI: 1.13-2.89; P(trend): 0.01). In the case-only survival analysis, we observed 123 events during 19,354 person-years. There were suggestive, but not statistically significant, positive associations between postdiagnostic poultry (HR ≥ 3.5 vs. <1.5 servings per week: 1.69; 95% CI: 0.96-2.99; P(trend): 0.07) and postdiagnostic processed red meat (HR ≥ 3 vs. <0.5 servings per week: 1.45; 95% CI: 0.73-2.87; P(trend): 0.08) and risk of progression of localized prostate cancer to lethal disease. In conclusion, consumption of eggs may increase risk of developing a lethal form of prostate cancer among healthy men. SN - 1940-6215 UR - https://www.unboundmedicine.com/medline/citation/21930800/full_citation L2 - http://cancerpreventionresearch.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=21930800 DB - PRIME DP - Unbound Medicine ER -