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High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease.
Kidney Int. 2012 Feb; 81(3):300-6.KI

Abstract

Chronic kidney disease is considered an inflammatory state and a high fiber intake is associated with decreased inflammation in the general population. Here, we determined whether fiber intake is associated with decreased inflammation and mortality in chronic kidney disease, and whether kidney disease modifies the associations of fiber intake with inflammation and mortality. To do this, we analyzed data from 14,543 participants in the National Health and Nutrition Examination Survey III. The prevalence of chronic kidney disease (estimated glomerular filtration rate less than 60 ml/min per 1.73 m(2)) was 5.8%. For each 10-g/day increase in total fiber intake, the odds of elevated serum C-reactive protein levels were decreased by 11% and 38% in those without and with kidney disease, respectively. Dietary total fiber intake was not significantly associated with mortality in those without but was inversely related to mortality in those with kidney disease. The relationship of total fiber with inflammation and mortality differed significantly in those with and without kidney disease. Thus, high dietary total fiber intake is associated with lower risk of inflammation and mortality in kidney disease and these associations are stronger in magnitude in those with kidney disease. Interventional trials are needed to establish the effects of fiber intake on inflammation and mortality in kidney disease.

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Authors+Show Affiliations

Krishnamurthy VM
VA Salt Lake City Health Care System, Salt Lake City, Utah, USA.
Wei G
No affiliation info available
Baird BC
No affiliation info available
Murtaugh M
No affiliation info available
Chonchol MB
No affiliation info available
Raphael KL
No affiliation info available
Greene T
No affiliation info available
Beddhu S
No affiliation info available

MeSH

AdultAgedC-Reactive ProteinChronic DiseaseDietary FiberFemaleHumansInflammationKidney DiseasesMaleMiddle Aged

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22012132

Clinical Trial Links

Effects of Short-chain Fatty Acids on Inflammatory and Metabolic Parameters in Maintenance Hemodialysis

Citation

Krishnamurthy, Vidya M Raj, et al. "High Dietary Fiber Intake Is Associated With Decreased Inflammation and All-cause Mortality in Patients With Chronic Kidney Disease." Kidney International, vol. 81, no. 3, 2012, pp. 300-6.
Krishnamurthy VM, Wei G, Baird BC, et al. High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease. Kidney Int. 2012;81(3):300-6.
Krishnamurthy, V. M., Wei, G., Baird, B. C., Murtaugh, M., Chonchol, M. B., Raphael, K. L., Greene, T., & Beddhu, S. (2012). High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease. Kidney International, 81(3), 300-6. https://doi.org/10.1038/ki.2011.355
Krishnamurthy VM, et al. High Dietary Fiber Intake Is Associated With Decreased Inflammation and All-cause Mortality in Patients With Chronic Kidney Disease. Kidney Int. 2012;81(3):300-6. PubMed PMID: 22012132.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease. AU - Krishnamurthy,Vidya M Raj, AU - Wei,Guo, AU - Baird,Bradley C, AU - Murtaugh,Maureen, AU - Chonchol,Michel B, AU - Raphael,Kalani L, AU - Greene,Tom, AU - Beddhu,Srinivasan, Y1 - 2011/10/19/ PY - 2011/10/21/entrez PY - 2011/10/21/pubmed PY - 2012/5/5/medline SP - 300 EP - 6 JF - Kidney international JO - Kidney Int VL - 81 IS - 3 N2 - Chronic kidney disease is considered an inflammatory state and a high fiber intake is associated with decreased inflammation in the general population. Here, we determined whether fiber intake is associated with decreased inflammation and mortality in chronic kidney disease, and whether kidney disease modifies the associations of fiber intake with inflammation and mortality. To do this, we analyzed data from 14,543 participants in the National Health and Nutrition Examination Survey III. The prevalence of chronic kidney disease (estimated glomerular filtration rate less than 60 ml/min per 1.73 m(2)) was 5.8%. For each 10-g/day increase in total fiber intake, the odds of elevated serum C-reactive protein levels were decreased by 11% and 38% in those without and with kidney disease, respectively. Dietary total fiber intake was not significantly associated with mortality in those without but was inversely related to mortality in those with kidney disease. The relationship of total fiber with inflammation and mortality differed significantly in those with and without kidney disease. Thus, high dietary total fiber intake is associated with lower risk of inflammation and mortality in kidney disease and these associations are stronger in magnitude in those with kidney disease. Interventional trials are needed to establish the effects of fiber intake on inflammation and mortality in kidney disease. SN - 1523-1755 UR - https://www.unboundmedicine.com/medline/citation/22012132/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0085-2538(15)55290-3 DB - PRIME DP - Unbound Medicine ER -