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High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease.

Abstract

Chronic kidney disease is considered an inflammatory state and a high fiber intake is associated with decreased inflammation in the general population. Here, we determined whether fiber intake is associated with decreased inflammation and mortality in chronic kidney disease, and whether kidney disease modifies the associations of fiber intake with inflammation and mortality. To do this, we analyzed data from 14,543 participants in the National Health and Nutrition Examination Survey III. The prevalence of chronic kidney disease (estimated glomerular filtration rate less than 60 ml/min per 1.73 m(2)) was 5.8%. For each 10-g/day increase in total fiber intake, the odds of elevated serum C-reactive protein levels were decreased by 11% and 38% in those without and with kidney disease, respectively. Dietary total fiber intake was not significantly associated with mortality in those without but was inversely related to mortality in those with kidney disease. The relationship of total fiber with inflammation and mortality differed significantly in those with and without kidney disease. Thus, high dietary total fiber intake is associated with lower risk of inflammation and mortality in kidney disease and these associations are stronger in magnitude in those with kidney disease. Interventional trials are needed to establish the effects of fiber intake on inflammation and mortality in kidney disease.

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  • Publisher Full Text
  • Authors

    , , , , , , ,

    Source

    Kidney international 81:3 2012 Feb pg 300-6

    MeSH

    Adult
    Aged
    C-Reactive Protein
    Chronic Disease
    Dietary Fiber
    Female
    Humans
    Inflammation
    Kidney Diseases
    Male
    Middle Aged

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22012132

    Citation

    TY - JOUR T1 - High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease. AU - Krishnamurthy,Vidya M Raj, AU - Wei,Guo, AU - Baird,Bradley C, AU - Murtaugh,Maureen, AU - Chonchol,Michel B, AU - Raphael,Kalani L, AU - Greene,Tom, AU - Beddhu,Srinivasan, Y1 - 2011/10/19/ PY - 2011/10/19/aheadofprint PY - 2011/10/21/entrez PY - 2011/10/21/pubmed PY - 2012/5/5/medline SP - 300 EP - 6 JF - Kidney international JO - Kidney Int. VL - 81 IS - 3 N2 - Chronic kidney disease is considered an inflammatory state and a high fiber intake is associated with decreased inflammation in the general population. Here, we determined whether fiber intake is associated with decreased inflammation and mortality in chronic kidney disease, and whether kidney disease modifies the associations of fiber intake with inflammation and mortality. To do this, we analyzed data from 14,543 participants in the National Health and Nutrition Examination Survey III. The prevalence of chronic kidney disease (estimated glomerular filtration rate less than 60 ml/min per 1.73 m(2)) was 5.8%. For each 10-g/day increase in total fiber intake, the odds of elevated serum C-reactive protein levels were decreased by 11% and 38% in those without and with kidney disease, respectively. Dietary total fiber intake was not significantly associated with mortality in those without but was inversely related to mortality in those with kidney disease. The relationship of total fiber with inflammation and mortality differed significantly in those with and without kidney disease. Thus, high dietary total fiber intake is associated with lower risk of inflammation and mortality in kidney disease and these associations are stronger in magnitude in those with kidney disease. Interventional trials are needed to establish the effects of fiber intake on inflammation and mortality in kidney disease. SN - 1523-1755 UR - https://www.unboundmedicine.com/medline/citation/22012132/full_citation L2 - http://dx.doi.org/10.1038/ki.2011.355 ER -