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Chronic widespread pain: from peripheral to central evolution.

Abstract

Chronic pain can be classified as localised, regional or widespread, and its high prevalence in the general population seems to increase with age. The majority of cases present with musculoskeletal pain. The conditions associated with chronic widespread pain (CWP) are highly burdensome as their characteristic symptoms may include multifocal pain, fatigue, insomnia, memory difficulties and a higher rate of concomitant mood disorders. After many years of debate, it is still unclear whether CWP (central sensitisation) is an entirely explainable neurotransmitter-related process or is partially or totally due to individual cognitive experiences and evaluations. The two models (neurochemical and biopsychosocial) also affect our ability to find therapeutic answers.

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  • Authors+Show Affiliations

    ,

    Rheumatology Unit, L. Sacco University Hospital, Milan, Italy. sarzi@tiscali.it

    ,

    Source

    MeSH

    Central Nervous System Diseases
    Central Nervous System Sensitization
    Chronic Pain
    Cognition
    Fibromyalgia
    Humans
    Neurotransmitter Agents
    Peripheral Nervous System Diseases
    Risk Factors
    Somatoform Disorders
    Syndrome

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    22094190

    Citation

    Sarzi-Puttini, Piercarlo, et al. "Chronic Widespread Pain: From Peripheral to Central Evolution." Best Practice & Research. Clinical Rheumatology, vol. 25, no. 2, 2011, pp. 133-9.
    Sarzi-Puttini P, Atzeni F, Mease PJ. Chronic widespread pain: from peripheral to central evolution. Best Pract Res Clin Rheumatol. 2011;25(2):133-9.
    Sarzi-Puttini, P., Atzeni, F., & Mease, P. J. (2011). Chronic widespread pain: from peripheral to central evolution. Best Practice & Research. Clinical Rheumatology, 25(2), pp. 133-9. doi:10.1016/j.berh.2011.04.001.
    Sarzi-Puttini P, Atzeni F, Mease PJ. Chronic Widespread Pain: From Peripheral to Central Evolution. Best Pract Res Clin Rheumatol. 2011;25(2):133-9. PubMed PMID: 22094190.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Chronic widespread pain: from peripheral to central evolution. AU - Sarzi-Puttini,Piercarlo, AU - Atzeni,Fabiola, AU - Mease,Philip J, PY - 2011/02/10/received PY - 2011/02/10/accepted PY - 2011/11/19/entrez PY - 2011/11/19/pubmed PY - 2012/3/16/medline SP - 133 EP - 9 JF - Best practice & research. Clinical rheumatology JO - Best Pract Res Clin Rheumatol VL - 25 IS - 2 N2 - Chronic pain can be classified as localised, regional or widespread, and its high prevalence in the general population seems to increase with age. The majority of cases present with musculoskeletal pain. The conditions associated with chronic widespread pain (CWP) are highly burdensome as their characteristic symptoms may include multifocal pain, fatigue, insomnia, memory difficulties and a higher rate of concomitant mood disorders. After many years of debate, it is still unclear whether CWP (central sensitisation) is an entirely explainable neurotransmitter-related process or is partially or totally due to individual cognitive experiences and evaluations. The two models (neurochemical and biopsychosocial) also affect our ability to find therapeutic answers. SN - 1532-1770 UR - https://www.unboundmedicine.com/medline/citation/22094190/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6942(11)00035-0 DB - PRIME DP - Unbound Medicine ER -