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A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease.
J Nutr 2012; 142(1):99-104JN

Abstract

Certain algae contain the (n-3) fatty acid DHA, yet the relation between algal oil supplementation and cardiovascular disease risk factors has not been systematically examined. Our objective was to examine the relation between algal oil supplementation and cardiovascular disease risk factors. We conducted a systematic review of randomized controlled trials published between 1996 and 2011 examining the relation between algal oil supplementation and cardiovascular disease risk factors and performed a meta-analysis of the association between algal oil DHA supplementation and changes in the concentrations of TG, LDL-cholesterol (LDL-C), and HDL-cholesterol (HDL-C). We identified 11 randomized controlled trials with 485 healthy participants that evaluated the relation between algal oil DHA supplementation and TG, LDL-C, and HDL-C. The median dose of algal DHA was 1.68 g/d. The pooled estimate for the change in TG concentration was -0.20 mmol/L (95% CI: -0.27 to -0.14), 0.23 mmol/L (95% CI: 0.16-0.30) for LDL-C, and 0.07 mmol/L (95% CI: 0.05-0.10) for HDL-C. DHA supplementation from algal oil, a marine source of (n-3) fatty acids not extracted from fish, may reduce serum TG and increase HDL-C and LDL-C in persons without coronary heart disease.

Authors+Show Affiliations

Wellness Institute of the Cleveland Clinic, Lyndhurst, OH, USA. bernsta2@ccf.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

22113870

Citation

Bernstein, Adam M., et al. "A Meta-analysis Shows That Docosahexaenoic Acid From Algal Oil Reduces Serum Triglycerides and Increases HDL-cholesterol and LDL-cholesterol in Persons Without Coronary Heart Disease." The Journal of Nutrition, vol. 142, no. 1, 2012, pp. 99-104.
Bernstein AM, Ding EL, Willett WC, et al. A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. J Nutr. 2012;142(1):99-104.
Bernstein, A. M., Ding, E. L., Willett, W. C., & Rimm, E. B. (2012). A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. The Journal of Nutrition, 142(1), pp. 99-104. doi:10.3945/jn.111.148973.
Bernstein AM, et al. A Meta-analysis Shows That Docosahexaenoic Acid From Algal Oil Reduces Serum Triglycerides and Increases HDL-cholesterol and LDL-cholesterol in Persons Without Coronary Heart Disease. J Nutr. 2012;142(1):99-104. PubMed PMID: 22113870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. AU - Bernstein,Adam M, AU - Ding,Eric L, AU - Willett,Walter C, AU - Rimm,Eric B, Y1 - 2011/11/23/ PY - 2011/11/25/entrez PY - 2011/11/25/pubmed PY - 2012/2/14/medline SP - 99 EP - 104 JF - The Journal of nutrition JO - J. Nutr. VL - 142 IS - 1 N2 - Certain algae contain the (n-3) fatty acid DHA, yet the relation between algal oil supplementation and cardiovascular disease risk factors has not been systematically examined. Our objective was to examine the relation between algal oil supplementation and cardiovascular disease risk factors. We conducted a systematic review of randomized controlled trials published between 1996 and 2011 examining the relation between algal oil supplementation and cardiovascular disease risk factors and performed a meta-analysis of the association between algal oil DHA supplementation and changes in the concentrations of TG, LDL-cholesterol (LDL-C), and HDL-cholesterol (HDL-C). We identified 11 randomized controlled trials with 485 healthy participants that evaluated the relation between algal oil DHA supplementation and TG, LDL-C, and HDL-C. The median dose of algal DHA was 1.68 g/d. The pooled estimate for the change in TG concentration was -0.20 mmol/L (95% CI: -0.27 to -0.14), 0.23 mmol/L (95% CI: 0.16-0.30) for LDL-C, and 0.07 mmol/L (95% CI: 0.05-0.10) for HDL-C. DHA supplementation from algal oil, a marine source of (n-3) fatty acids not extracted from fish, may reduce serum TG and increase HDL-C and LDL-C in persons without coronary heart disease. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/22113870/full_citation L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.111.148973 DB - PRIME DP - Unbound Medicine ER -