Tags

Type your tag names separated by a space and hit enter

A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease.

Abstract

Certain algae contain the (n-3) fatty acid DHA, yet the relation between algal oil supplementation and cardiovascular disease risk factors has not been systematically examined. Our objective was to examine the relation between algal oil supplementation and cardiovascular disease risk factors. We conducted a systematic review of randomized controlled trials published between 1996 and 2011 examining the relation between algal oil supplementation and cardiovascular disease risk factors and performed a meta-analysis of the association between algal oil DHA supplementation and changes in the concentrations of TG, LDL-cholesterol (LDL-C), and HDL-cholesterol (HDL-C). We identified 11 randomized controlled trials with 485 healthy participants that evaluated the relation between algal oil DHA supplementation and TG, LDL-C, and HDL-C. The median dose of algal DHA was 1.68 g/d. The pooled estimate for the change in TG concentration was -0.20 mmol/L (95% CI: -0.27 to -0.14), 0.23 mmol/L (95% CI: 0.16-0.30) for LDL-C, and 0.07 mmol/L (95% CI: 0.05-0.10) for HDL-C. DHA supplementation from algal oil, a marine source of (n-3) fatty acids not extracted from fish, may reduce serum TG and increase HDL-C and LDL-C in persons without coronary heart disease.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Wellness Institute of the Cleveland Clinic, Lyndhurst, OH, USA. bernsta2@ccf.org

    , ,

    Source

    The Journal of nutrition 142:1 2012 Jan pg 99-104

    MeSH

    Cholesterol, HDL
    Cholesterol, LDL
    Coronary Disease
    Docosahexaenoic Acids
    Humans
    Plant Oils
    Triglycerides

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    22113870

    Citation

    Bernstein, Adam M., et al. "A Meta-analysis Shows That Docosahexaenoic Acid From Algal Oil Reduces Serum Triglycerides and Increases HDL-cholesterol and LDL-cholesterol in Persons Without Coronary Heart Disease." The Journal of Nutrition, vol. 142, no. 1, 2012, pp. 99-104.
    Bernstein AM, Ding EL, Willett WC, et al. A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. J Nutr. 2012;142(1):99-104.
    Bernstein, A. M., Ding, E. L., Willett, W. C., & Rimm, E. B. (2012). A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. The Journal of Nutrition, 142(1), pp. 99-104. doi:10.3945/jn.111.148973.
    Bernstein AM, et al. A Meta-analysis Shows That Docosahexaenoic Acid From Algal Oil Reduces Serum Triglycerides and Increases HDL-cholesterol and LDL-cholesterol in Persons Without Coronary Heart Disease. J Nutr. 2012;142(1):99-104. PubMed PMID: 22113870.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. AU - Bernstein,Adam M, AU - Ding,Eric L, AU - Willett,Walter C, AU - Rimm,Eric B, Y1 - 2011/11/23/ PY - 2011/11/25/entrez PY - 2011/11/25/pubmed PY - 2012/2/14/medline SP - 99 EP - 104 JF - The Journal of nutrition JO - J. Nutr. VL - 142 IS - 1 N2 - Certain algae contain the (n-3) fatty acid DHA, yet the relation between algal oil supplementation and cardiovascular disease risk factors has not been systematically examined. Our objective was to examine the relation between algal oil supplementation and cardiovascular disease risk factors. We conducted a systematic review of randomized controlled trials published between 1996 and 2011 examining the relation between algal oil supplementation and cardiovascular disease risk factors and performed a meta-analysis of the association between algal oil DHA supplementation and changes in the concentrations of TG, LDL-cholesterol (LDL-C), and HDL-cholesterol (HDL-C). We identified 11 randomized controlled trials with 485 healthy participants that evaluated the relation between algal oil DHA supplementation and TG, LDL-C, and HDL-C. The median dose of algal DHA was 1.68 g/d. The pooled estimate for the change in TG concentration was -0.20 mmol/L (95% CI: -0.27 to -0.14), 0.23 mmol/L (95% CI: 0.16-0.30) for LDL-C, and 0.07 mmol/L (95% CI: 0.05-0.10) for HDL-C. DHA supplementation from algal oil, a marine source of (n-3) fatty acids not extracted from fish, may reduce serum TG and increase HDL-C and LDL-C in persons without coronary heart disease. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/22113870/full_citation L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.111.148973 DB - PRIME DP - Unbound Medicine ER -