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Intake of antioxidant nutrients and risk of non-Hodgkin's Lymphoma in the Women's Health Initiative.

Abstract

Incidence rates of non-Hodgkin's lymphoma (NHL) increased substantially in the United States and worldwide during the latter part of the 20(th) century, but little is known about the etiology of this condition. Antioxidant nutrients may reduce the risk of NHL by quenching free radicals, which may contribute to carcinogenesis by damaging DNA and lipid membranes. We examined the association of intake of vitamin A and antioxidant nutrients with risk of NHL and its major subtypes in 1,104 cases of NHL identified among 154,363 postmenopausal women followed for an average of 11 yr in the Women's Health Initiative. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). Of all nutrients examined, only total vitamin A intake (from diet and supplements combined) was inversely associated with risk of NHL overall (multivariate adjusted HR for highest vs. lowest quartile 0.83, 95% CI 0.69-0.99), whereas total vitamin C intake was inversely associated with risk of diffuse large B-cell lymphoma (HR for highest vs. lowest quartile 0.69, 95% CI 0.49-0.98). Overall, this study provides some evidence of inverse associations of intake of total vitamin A and total vitamin C with the risk of NHL and diffuse lymphoma, respectively.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA. geoffrey.kabat@einstein.yu.edu

    , , , ,

    Source

    Nutrition and cancer 64:2 2012 pg 245-54

    MeSH

    Aged
    Antioxidants
    Ascorbic Acid
    Diet
    Dietary Fats
    Dietary Supplements
    Estrogen Replacement Therapy
    Female
    Humans
    Lymphoma, Non-Hodgkin
    Middle Aged
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    United States
    Vitamin A
    Vitamins
    Women's Health

    Pub Type(s)

    Journal Article
    Multicenter Study

    Language

    eng

    PubMed ID

    22211937

    Citation

    Kabat, Geoffrey C., et al. "Intake of Antioxidant Nutrients and Risk of non-Hodgkin's Lymphoma in the Women's Health Initiative." Nutrition and Cancer, vol. 64, no. 2, 2012, pp. 245-54.
    Kabat GC, Kim MY, Wactawski-Wende J, et al. Intake of antioxidant nutrients and risk of non-Hodgkin's Lymphoma in the Women's Health Initiative. Nutr Cancer. 2012;64(2):245-54.
    Kabat, G. C., Kim, M. Y., Wactawski-Wende, J., Shikany, J. M., Vitolins, M. Z., & Rohan, T. E. (2012). Intake of antioxidant nutrients and risk of non-Hodgkin's Lymphoma in the Women's Health Initiative. Nutrition and Cancer, 64(2), pp. 245-54. doi:10.1080/01635581.2012.642454.
    Kabat GC, et al. Intake of Antioxidant Nutrients and Risk of non-Hodgkin's Lymphoma in the Women's Health Initiative. Nutr Cancer. 2012;64(2):245-54. PubMed PMID: 22211937.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intake of antioxidant nutrients and risk of non-Hodgkin's Lymphoma in the Women's Health Initiative. AU - Kabat,Geoffrey C, AU - Kim,Mimi Y, AU - Wactawski-Wende,Jean, AU - Shikany,James M, AU - Vitolins,Mara Z, AU - Rohan,Thomas E, Y1 - 2012/01/02/ PY - 2012/1/4/entrez PY - 2012/1/4/pubmed PY - 2012/6/16/medline SP - 245 EP - 54 JF - Nutrition and cancer JO - Nutr Cancer VL - 64 IS - 2 N2 - Incidence rates of non-Hodgkin's lymphoma (NHL) increased substantially in the United States and worldwide during the latter part of the 20(th) century, but little is known about the etiology of this condition. Antioxidant nutrients may reduce the risk of NHL by quenching free radicals, which may contribute to carcinogenesis by damaging DNA and lipid membranes. We examined the association of intake of vitamin A and antioxidant nutrients with risk of NHL and its major subtypes in 1,104 cases of NHL identified among 154,363 postmenopausal women followed for an average of 11 yr in the Women's Health Initiative. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). Of all nutrients examined, only total vitamin A intake (from diet and supplements combined) was inversely associated with risk of NHL overall (multivariate adjusted HR for highest vs. lowest quartile 0.83, 95% CI 0.69-0.99), whereas total vitamin C intake was inversely associated with risk of diffuse large B-cell lymphoma (HR for highest vs. lowest quartile 0.69, 95% CI 0.49-0.98). Overall, this study provides some evidence of inverse associations of intake of total vitamin A and total vitamin C with the risk of NHL and diffuse lymphoma, respectively. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/22211937/full_citation L2 - http://www.tandfonline.com/doi/full/10.1080/01635581.2012.642454 DB - PRIME DP - Unbound Medicine ER -