Tags

Type your tag names separated by a space and hit enter

Dietary fat intake and risk of ovarian cancer in the NIH-AARP Diet and Health Study.

Abstract

BACKGROUND

Fat intake has been postulated to increase risk of ovarian cancer, but previous studies have reported inconsistent results.

METHODS

The NIH-AARP Diet and Health Study, a large prospective cohort, assessed diet using a food frequency questionnaire at baseline in 1995-1996. During an average of 9 years of follow-up, 695 ovarian cancer cases were ascertained through the state cancer registry database. The relative risks (RRs) and 95% confidence interval (CI) were estimated using a Cox proportional hazard model.

RESULTS

Women in the highest vs the lowest quintile of total fat intake had a 28% increased risk of ovarian cancer (RR(Q5 vs Q1)=1.28, 95% CI: 1.01-1.63). Fat intake from animal sources (RR(Q5 vs Q1)=1.30; 95% CI: 1.02-1.66), but not from plant sources, was positively associated with ovarian cancer risk. Saturated and monounsaturated fat intakes were not related to risk of ovarian cancer, but polyunsaturated fat intake showed a weak positive association. The association between total fat intake and ovarian cancer was stronger in women who were nulliparous or never used oral contraceptives.

CONCLUSION

Fat intake, especially from animal sources, was related to an increased risk of ovarian cancer. The association may be modified by parity and oral contraceptive use, which warrants further investigation.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA.

    , , ,

    Source

    British journal of cancer 106:3 2012 Jan 31 pg 596-602

    MeSH

    Diet Surveys
    Dietary Fats
    Female
    Humans
    Middle Aged
    National Institutes of Health (U.S.)
    Ovarian Neoplasms
    Proportional Hazards Models
    Prospective Studies
    Registries
    Risk Factors
    Societies
    Surveys and Questionnaires
    United States
    Women's Health

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    22223086

    Citation

    Blank, M M., et al. "Dietary Fat Intake and Risk of Ovarian Cancer in the NIH-AARP Diet and Health Study." British Journal of Cancer, vol. 106, no. 3, 2012, pp. 596-602.
    Blank MM, Wentzensen N, Murphy MA, et al. Dietary fat intake and risk of ovarian cancer in the NIH-AARP Diet and Health Study. Br J Cancer. 2012;106(3):596-602.
    Blank, M. M., Wentzensen, N., Murphy, M. A., Hollenbeck, A., & Park, Y. (2012). Dietary fat intake and risk of ovarian cancer in the NIH-AARP Diet and Health Study. British Journal of Cancer, 106(3), pp. 596-602. doi:10.1038/bjc.2011.572.
    Blank MM, et al. Dietary Fat Intake and Risk of Ovarian Cancer in the NIH-AARP Diet and Health Study. Br J Cancer. 2012 Jan 31;106(3):596-602. PubMed PMID: 22223086.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fat intake and risk of ovarian cancer in the NIH-AARP Diet and Health Study. AU - Blank,M M, AU - Wentzensen,N, AU - Murphy,M A, AU - Hollenbeck,A, AU - Park,Y, Y1 - 2012/01/05/ PY - 2012/1/7/entrez PY - 2012/1/10/pubmed PY - 2012/3/28/medline SP - 596 EP - 602 JF - British journal of cancer JO - Br. J. Cancer VL - 106 IS - 3 N2 - BACKGROUND: Fat intake has been postulated to increase risk of ovarian cancer, but previous studies have reported inconsistent results. METHODS: The NIH-AARP Diet and Health Study, a large prospective cohort, assessed diet using a food frequency questionnaire at baseline in 1995-1996. During an average of 9 years of follow-up, 695 ovarian cancer cases were ascertained through the state cancer registry database. The relative risks (RRs) and 95% confidence interval (CI) were estimated using a Cox proportional hazard model. RESULTS: Women in the highest vs the lowest quintile of total fat intake had a 28% increased risk of ovarian cancer (RR(Q5 vs Q1)=1.28, 95% CI: 1.01-1.63). Fat intake from animal sources (RR(Q5 vs Q1)=1.30; 95% CI: 1.02-1.66), but not from plant sources, was positively associated with ovarian cancer risk. Saturated and monounsaturated fat intakes were not related to risk of ovarian cancer, but polyunsaturated fat intake showed a weak positive association. The association between total fat intake and ovarian cancer was stronger in women who were nulliparous or never used oral contraceptives. CONCLUSION: Fat intake, especially from animal sources, was related to an increased risk of ovarian cancer. The association may be modified by parity and oral contraceptive use, which warrants further investigation. SN - 1532-1827 UR - https://www.unboundmedicine.com/medline/citation/22223086/full_citation L2 - http://dx.doi.org/10.1038/bjc.2011.572 DB - PRIME DP - Unbound Medicine ER -