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Postdiagnosis change in bodyweight and survival after breast cancer diagnosis.
Epidemiology. 2012 Mar; 23(2):320-7.E

Abstract

BACKGROUND

Weight gain after diagnosis is common among women with breast cancer, yet results have been inconsistent among the few studies examining its effects on survival.

METHODS

We examined the effects of weight gain on mortality among a cohort of 1436 women diagnosed with a first primary breast cancer in 1996-1997, on Long Island, NY. Subjects were interviewed soon after diagnosis and again after approximately 5 years. Weight was assessed at each decade of adult life; 1 year before, at, and 1 year after diagnosis; and at the time of follow-up. Mortality through the end of 2005 was assessed using the National Death Index. Proportional hazards regression was used while using a selection model to account for missing data.

RESULTS

Compared with women who maintained their prediagnosis weight (±5%), those who gained more than 10% after diagnosis had worse survival (hazard ratio [HR] = 2.67; [95% credible interval = 1.37-5.05]). The effect was more pronounced during the first 2 years after diagnosis (>5% gain: all-cause mortality in the first 2 years, HR = 5.87 [0.89-47.8] vs. after 2 years, 1.49 [0.85-2.57]); among women overweight before diagnosis (overweight women: all-cause HR = 1.91 [0.91-3.88] vs. ideal-weight women, 1.39 [0.62-3.01]); and for women who had gained at least 3 kg in adulthood before diagnosis (≥3-kg gain before diagnosis: 1.80 [0.99-3.26 vs. <3 kg gain before diagnosis: 1.07 [0.30-3.37].

CONCLUSIONS

These results highlight the importance of weight maintenance for women after breast cancer diagnosis.

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Authors+Show Affiliations

Bradshaw PT
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7535, USA. patrickb@email.unc.edu
Ibrahim JG
No affiliation info available
Stevens J
No affiliation info available
Cleveland R
No affiliation info available
Abrahamson PE
No affiliation info available
Satia JA
No affiliation info available
Teitelbaum SL
No affiliation info available
Neugut AI
No affiliation info available
Gammon MD
No affiliation info available

MeSH

AdultAgedAged, 80 and overBody WeightBreast NeoplasmsFemaleHumansMiddle AgedNew YorkProportional Hazards ModelsSurvival AnalysisWeight Gain

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22317813

Citation

Bradshaw, Patrick T., et al. "Postdiagnosis Change in Bodyweight and Survival After Breast Cancer Diagnosis." Epidemiology (Cambridge, Mass.), vol. 23, no. 2, 2012, pp. 320-7.
Bradshaw PT, Ibrahim JG, Stevens J, et al. Postdiagnosis change in bodyweight and survival after breast cancer diagnosis. Epidemiology. 2012;23(2):320-7.
Bradshaw, P. T., Ibrahim, J. G., Stevens, J., Cleveland, R., Abrahamson, P. E., Satia, J. A., Teitelbaum, S. L., Neugut, A. I., & Gammon, M. D. (2012). Postdiagnosis change in bodyweight and survival after breast cancer diagnosis. Epidemiology (Cambridge, Mass.), 23(2), 320-7. https://doi.org/10.1097/EDE.0b013e31824596a1
Bradshaw PT, et al. Postdiagnosis Change in Bodyweight and Survival After Breast Cancer Diagnosis. Epidemiology. 2012;23(2):320-7. PubMed PMID: 22317813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postdiagnosis change in bodyweight and survival after breast cancer diagnosis. AU - Bradshaw,Patrick T, AU - Ibrahim,Joseph G, AU - Stevens,June, AU - Cleveland,Rebecca, AU - Abrahamson,Page E, AU - Satia,Jessie A, AU - Teitelbaum,Susan L, AU - Neugut,Alfred I, AU - Gammon,Marilie D, PY - 2012/2/10/entrez PY - 2012/2/10/pubmed PY - 2012/5/26/medline SP - 320 EP - 7 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 23 IS - 2 N2 - BACKGROUND: Weight gain after diagnosis is common among women with breast cancer, yet results have been inconsistent among the few studies examining its effects on survival. METHODS: We examined the effects of weight gain on mortality among a cohort of 1436 women diagnosed with a first primary breast cancer in 1996-1997, on Long Island, NY. Subjects were interviewed soon after diagnosis and again after approximately 5 years. Weight was assessed at each decade of adult life; 1 year before, at, and 1 year after diagnosis; and at the time of follow-up. Mortality through the end of 2005 was assessed using the National Death Index. Proportional hazards regression was used while using a selection model to account for missing data. RESULTS: Compared with women who maintained their prediagnosis weight (±5%), those who gained more than 10% after diagnosis had worse survival (hazard ratio [HR] = 2.67; [95% credible interval = 1.37-5.05]). The effect was more pronounced during the first 2 years after diagnosis (>5% gain: all-cause mortality in the first 2 years, HR = 5.87 [0.89-47.8] vs. after 2 years, 1.49 [0.85-2.57]); among women overweight before diagnosis (overweight women: all-cause HR = 1.91 [0.91-3.88] vs. ideal-weight women, 1.39 [0.62-3.01]); and for women who had gained at least 3 kg in adulthood before diagnosis (≥3-kg gain before diagnosis: 1.80 [0.99-3.26 vs. <3 kg gain before diagnosis: 1.07 [0.30-3.37]. CONCLUSIONS: These results highlight the importance of weight maintenance for women after breast cancer diagnosis. SN - 1531-5487 UR - https://www.unboundmedicine.com/medline/citation/22317813/full_citation L2 - https://doi.org/10.1097/EDE.0b013e31824596a1 DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓55 ↑32]

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