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Multiple roles of dihomo-γ-linolenic acid against proliferation diseases.

Abstract

Considerable arguments remain regarding the diverse biological activities of polyunsaturated fatty acids (PUFA). One of the most interesting but controversial dietary approaches focused on the diverse function of dihomo-dietary γ-linolenic acid (DGLA) in anti-inflammation and anti-proliferation diseases, especially for cancers. This strategy is based on the ability of DGLA to interfere in cellular lipid metabolism and eicosanoid (cyclooxygenase and lipoxygenase) biosynthesis. Subsequently, DGLA can be further converted by inflammatory cells to 15-(S)-hydroxy-8,11,13-eicosatrienoic acid and prostaglandin E1 (PGE1). This is noteworthy because these compounds possess both anti-inflammatory and anti-proliferative properties. PGE1 could also induce growth inhibition and differentiation of cancer cells. Although the mechanism of DGLA has not yet been elucidated, it is significant to anticipate the antitumor potential benefits from DGLA.

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  • Authors+Show Affiliations

    ,

    Laboratory of Molecular Pathology, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China. wxpphd@yahoo.cn

    ,

    Source

    Lipids in health and disease 11: 2012 Feb 14 pg 25

    MeSH

    8,11,14-Eicosatrienoic Acid
    Animals
    Anti-Inflammatory Agents
    Antineoplastic Agents
    Cell Differentiation
    Cell Proliferation
    Humans
    Inflammation
    Neoplasms
    Oxidation-Reduction

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    22333072

    Citation

    Wang, Xiaoping, et al. "Multiple Roles of Dihomo-γ-linolenic Acid Against Proliferation Diseases." Lipids in Health and Disease, vol. 11, 2012, p. 25.
    Wang X, Lin H, Gu Y. Multiple roles of dihomo-γ-linolenic acid against proliferation diseases. Lipids Health Dis. 2012;11:25.
    Wang, X., Lin, H., & Gu, Y. (2012). Multiple roles of dihomo-γ-linolenic acid against proliferation diseases. Lipids in Health and Disease, 11, p. 25. doi:10.1186/1476-511X-11-25.
    Wang X, Lin H, Gu Y. Multiple Roles of Dihomo-γ-linolenic Acid Against Proliferation Diseases. Lipids Health Dis. 2012 Feb 14;11:25. PubMed PMID: 22333072.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Multiple roles of dihomo-γ-linolenic acid against proliferation diseases. AU - Wang,Xiaoping, AU - Lin,Huanping, AU - Gu,Yan, Y1 - 2012/02/14/ PY - 2011/12/23/received PY - 2012/02/14/accepted PY - 2012/2/16/entrez PY - 2012/2/16/pubmed PY - 2012/5/18/medline SP - 25 EP - 25 JF - Lipids in health and disease JO - Lipids Health Dis VL - 11 N2 - Considerable arguments remain regarding the diverse biological activities of polyunsaturated fatty acids (PUFA). One of the most interesting but controversial dietary approaches focused on the diverse function of dihomo-dietary γ-linolenic acid (DGLA) in anti-inflammation and anti-proliferation diseases, especially for cancers. This strategy is based on the ability of DGLA to interfere in cellular lipid metabolism and eicosanoid (cyclooxygenase and lipoxygenase) biosynthesis. Subsequently, DGLA can be further converted by inflammatory cells to 15-(S)-hydroxy-8,11,13-eicosatrienoic acid and prostaglandin E1 (PGE1). This is noteworthy because these compounds possess both anti-inflammatory and anti-proliferative properties. PGE1 could also induce growth inhibition and differentiation of cancer cells. Although the mechanism of DGLA has not yet been elucidated, it is significant to anticipate the antitumor potential benefits from DGLA. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/22333072/full_citation L2 - https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-11-25 DB - PRIME DP - Unbound Medicine ER -