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Multiple roles of dihomo-γ-linolenic acid against proliferation diseases.
Lipids Health Dis 2012; 11:25LH

Abstract

Considerable arguments remain regarding the diverse biological activities of polyunsaturated fatty acids (PUFA). One of the most interesting but controversial dietary approaches focused on the diverse function of dihomo-dietary γ-linolenic acid (DGLA) in anti-inflammation and anti-proliferation diseases, especially for cancers. This strategy is based on the ability of DGLA to interfere in cellular lipid metabolism and eicosanoid (cyclooxygenase and lipoxygenase) biosynthesis. Subsequently, DGLA can be further converted by inflammatory cells to 15-(S)-hydroxy-8,11,13-eicosatrienoic acid and prostaglandin E1 (PGE1). This is noteworthy because these compounds possess both anti-inflammatory and anti-proliferative properties. PGE1 could also induce growth inhibition and differentiation of cancer cells. Although the mechanism of DGLA has not yet been elucidated, it is significant to anticipate the antitumor potential benefits from DGLA.

Authors+Show Affiliations

Laboratory of Molecular Pathology, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China. wxpphd@yahoo.cnNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22333072

Citation

Wang, Xiaoping, et al. "Multiple Roles of Dihomo-γ-linolenic Acid Against Proliferation Diseases." Lipids in Health and Disease, vol. 11, 2012, p. 25.
Wang X, Lin H, Gu Y. Multiple roles of dihomo-γ-linolenic acid against proliferation diseases. Lipids Health Dis. 2012;11:25.
Wang, X., Lin, H., & Gu, Y. (2012). Multiple roles of dihomo-γ-linolenic acid against proliferation diseases. Lipids in Health and Disease, 11, p. 25. doi:10.1186/1476-511X-11-25.
Wang X, Lin H, Gu Y. Multiple Roles of Dihomo-γ-linolenic Acid Against Proliferation Diseases. Lipids Health Dis. 2012 Feb 14;11:25. PubMed PMID: 22333072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple roles of dihomo-γ-linolenic acid against proliferation diseases. AU - Wang,Xiaoping, AU - Lin,Huanping, AU - Gu,Yan, Y1 - 2012/02/14/ PY - 2011/12/23/received PY - 2012/02/14/accepted PY - 2012/2/16/entrez PY - 2012/2/16/pubmed PY - 2012/5/18/medline SP - 25 EP - 25 JF - Lipids in health and disease JO - Lipids Health Dis VL - 11 N2 - Considerable arguments remain regarding the diverse biological activities of polyunsaturated fatty acids (PUFA). One of the most interesting but controversial dietary approaches focused on the diverse function of dihomo-dietary γ-linolenic acid (DGLA) in anti-inflammation and anti-proliferation diseases, especially for cancers. This strategy is based on the ability of DGLA to interfere in cellular lipid metabolism and eicosanoid (cyclooxygenase and lipoxygenase) biosynthesis. Subsequently, DGLA can be further converted by inflammatory cells to 15-(S)-hydroxy-8,11,13-eicosatrienoic acid and prostaglandin E1 (PGE1). This is noteworthy because these compounds possess both anti-inflammatory and anti-proliferative properties. PGE1 could also induce growth inhibition and differentiation of cancer cells. Although the mechanism of DGLA has not yet been elucidated, it is significant to anticipate the antitumor potential benefits from DGLA. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/22333072/full_citation L2 - https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-11-25 DB - PRIME DP - Unbound Medicine ER -