Tags

Type your tag names separated by a space and hit enter

Synthesis and pharmacological activity of 2-alkylthio substituted thieno[2,3-d]pyrimidine-4-one and 5H-pyrimido [5,4-b]indol-4-one.
Pharmazie. 1990 Jul; 45(7):493-5.P

Abstract

Quaternary salts of several 2-alkylthio substituted derivatives of thieno [2,3-d]pyrimidin-4-one and 5H-pyrimido [5,4-b]indol-4-one with a basic group in position 2 of the alkyl chain were synthesized and screened for potential spasmolytic activity. These substances were prepared by condensation of the corresponding mercapto compounds with a 2-chloroalkyltertiary amine. The tertiary bases were quaternized with methyl iodide. Among the assayed compounds, the thieno [2-3-d]pyrimidin-4-one derivatives displayed a potent spasmolytic activity in the in vitro and in vivo assays.

Authors+Show Affiliations

Russo F
Istituto di Chimica Farmaceutica e Tossicologica dell'Università di Catania, Italy.
Santagati NA
No affiliation info available
Venturini R
No affiliation info available
Spampinato S
No affiliation info available

MeSH

AnimalsAorta, ThoracicCharcoalChemical PhenomenaChemistryGuinea PigsIleumIn Vitro TechniquesIndolesMaleMiceMuscle ContractionMuscle, SmoothMuscle, Smooth, VascularParasympatholyticsPyrimidinesPyrimidinonesRabbitsThiophenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2236192

Citation

Russo, F, et al. "Synthesis and Pharmacological Activity of 2-alkylthio Substituted Thieno[2,3-d]pyrimidine-4-one and 5H-pyrimido [5,4-b]indol-4-one." Die Pharmazie, vol. 45, no. 7, 1990, pp. 493-5.
Russo F, Santagati NA, Venturini R, et al. Synthesis and pharmacological activity of 2-alkylthio substituted thieno[2,3-d]pyrimidine-4-one and 5H-pyrimido [5,4-b]indol-4-one. Pharmazie. 1990;45(7):493-5.
Russo, F., Santagati, N. A., Venturini, R., & Spampinato, S. (1990). Synthesis and pharmacological activity of 2-alkylthio substituted thieno[2,3-d]pyrimidine-4-one and 5H-pyrimido [5,4-b]indol-4-one. Die Pharmazie, 45(7), 493-5.
Russo F, et al. Synthesis and Pharmacological Activity of 2-alkylthio Substituted Thieno[2,3-d]pyrimidine-4-one and 5H-pyrimido [5,4-b]indol-4-one. Pharmazie. 1990;45(7):493-5. PubMed PMID: 2236192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and pharmacological activity of 2-alkylthio substituted thieno[2,3-d]pyrimidine-4-one and 5H-pyrimido [5,4-b]indol-4-one. AU - Russo,F, AU - Santagati,N A, AU - Venturini,R, AU - Spampinato,S, PY - 1990/7/1/pubmed PY - 1990/7/1/medline PY - 1990/7/1/entrez SP - 493 EP - 5 JF - Die Pharmazie JO - Pharmazie VL - 45 IS - 7 N2 - Quaternary salts of several 2-alkylthio substituted derivatives of thieno [2,3-d]pyrimidin-4-one and 5H-pyrimido [5,4-b]indol-4-one with a basic group in position 2 of the alkyl chain were synthesized and screened for potential spasmolytic activity. These substances were prepared by condensation of the corresponding mercapto compounds with a 2-chloroalkyltertiary amine. The tertiary bases were quaternized with methyl iodide. Among the assayed compounds, the thieno [2-3-d]pyrimidin-4-one derivatives displayed a potent spasmolytic activity in the in vitro and in vivo assays. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/2236192 DB - PRIME DP - Unbound Medicine ER -

Related Citations

    More

    Others Viewed