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An update on the screening, diagnosis, management, and treatment of vitamin D deficiency in individuals with cystic fibrosis: evidence-based recommendations from the Cystic Fibrosis Foundation.

Abstract

OBJECTIVE

The objective was to develop evidence-based clinical care guidelines for the screening, diagnosis, management, and treatment of vitamin D deficiency in individuals with cystic fibrosis (CF).

PARTICIPANTS

The guidelines committee was comprised of physicians, registered dietitians, a pharmacist, a nurse, a parent of an individual with CF, and a health scientist, all with experience in CF.

PROCESS

Committee members developed questions specific to vitamin D health in individuals with CF. Systematic reviews were completed for each question. The committee reviewed and graded the available evidence and developed evidence-based recommendations and consensus recommendations when insufficient evidence was available. Each consensus recommendation was voted upon by an anonymous process.

CONCLUSIONS

Vitamin D deficiency is common in CF. Given the limited evidence specific to CF, the committee provided consensus recommendations for most of the recommendations. The committee recommends yearly screening for vitamin D status, preferably at the end of winter, using the serum 25-hydroxyvitamin D measurement, with a minimal 25-hydroxyvitamin D concentration of 30 ng/ml (75 nmol/liter) considered vitamin D sufficient in individuals with CF. Recommendations for age-specific vitamin D intake for all individuals with CF, form of vitamin D, and a stepwise approach to increase vitamin D intake when optimal vitamin D status is not achieved are delineated.

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  • Authors+Show Affiliations

    ,

    Emory University, Atlanta, Georgia 30322, USA.

    , , , , , , ,

    Source

    MeSH

    25-Hydroxyvitamin D 2
    Adolescent
    Adult
    Age Factors
    Calcifediol
    Child
    Cholecalciferol
    Cystic Fibrosis
    Dietary Supplements
    Ergocalciferols
    Evidence-Based Practice
    Humans
    Infant
    Malabsorption Syndromes
    Mass Screening
    Seasons
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Practice Guideline
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22399505

    Citation

    Tangpricha, V, et al. "An Update On the Screening, Diagnosis, Management, and Treatment of Vitamin D Deficiency in Individuals With Cystic Fibrosis: Evidence-based Recommendations From the Cystic Fibrosis Foundation." The Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 4, 2012, pp. 1082-93.
    Tangpricha V, Kelly A, Stephenson A, et al. An update on the screening, diagnosis, management, and treatment of vitamin D deficiency in individuals with cystic fibrosis: evidence-based recommendations from the Cystic Fibrosis Foundation. J Clin Endocrinol Metab. 2012;97(4):1082-93.
    Tangpricha, V., Kelly, A., Stephenson, A., Maguiness, K., Enders, J., Robinson, K. A., ... Borowitz, D. (2012). An update on the screening, diagnosis, management, and treatment of vitamin D deficiency in individuals with cystic fibrosis: evidence-based recommendations from the Cystic Fibrosis Foundation. The Journal of Clinical Endocrinology and Metabolism, 97(4), pp. 1082-93. doi:10.1210/jc.2011-3050.
    Tangpricha V, et al. An Update On the Screening, Diagnosis, Management, and Treatment of Vitamin D Deficiency in Individuals With Cystic Fibrosis: Evidence-based Recommendations From the Cystic Fibrosis Foundation. J Clin Endocrinol Metab. 2012;97(4):1082-93. PubMed PMID: 22399505.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - An update on the screening, diagnosis, management, and treatment of vitamin D deficiency in individuals with cystic fibrosis: evidence-based recommendations from the Cystic Fibrosis Foundation. AU - Tangpricha,V, AU - Kelly,A, AU - Stephenson,A, AU - Maguiness,K, AU - Enders,J, AU - Robinson,K A, AU - Marshall,B C, AU - Borowitz,D, AU - ,, Y1 - 2012/03/07/ PY - 2012/3/9/entrez PY - 2012/3/9/pubmed PY - 2012/6/12/medline SP - 1082 EP - 93 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 97 IS - 4 N2 - OBJECTIVE: The objective was to develop evidence-based clinical care guidelines for the screening, diagnosis, management, and treatment of vitamin D deficiency in individuals with cystic fibrosis (CF). PARTICIPANTS: The guidelines committee was comprised of physicians, registered dietitians, a pharmacist, a nurse, a parent of an individual with CF, and a health scientist, all with experience in CF. PROCESS: Committee members developed questions specific to vitamin D health in individuals with CF. Systematic reviews were completed for each question. The committee reviewed and graded the available evidence and developed evidence-based recommendations and consensus recommendations when insufficient evidence was available. Each consensus recommendation was voted upon by an anonymous process. CONCLUSIONS: Vitamin D deficiency is common in CF. Given the limited evidence specific to CF, the committee provided consensus recommendations for most of the recommendations. The committee recommends yearly screening for vitamin D status, preferably at the end of winter, using the serum 25-hydroxyvitamin D measurement, with a minimal 25-hydroxyvitamin D concentration of 30 ng/ml (75 nmol/liter) considered vitamin D sufficient in individuals with CF. Recommendations for age-specific vitamin D intake for all individuals with CF, form of vitamin D, and a stepwise approach to increase vitamin D intake when optimal vitamin D status is not achieved are delineated. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/22399505/full_citation L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2011-3050 DB - PRIME DP - Unbound Medicine ER -