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An update on the screening, diagnosis, management, and treatment of vitamin D deficiency in individuals with cystic fibrosis: evidence-based recommendations from the Cystic Fibrosis Foundation.
J Clin Endocrinol Metab 2012; 97(4):1082-93JC

Abstract

OBJECTIVE

The objective was to develop evidence-based clinical care guidelines for the screening, diagnosis, management, and treatment of vitamin D deficiency in individuals with cystic fibrosis (CF).

PARTICIPANTS

The guidelines committee was comprised of physicians, registered dietitians, a pharmacist, a nurse, a parent of an individual with CF, and a health scientist, all with experience in CF.

PROCESS

Committee members developed questions specific to vitamin D health in individuals with CF. Systematic reviews were completed for each question. The committee reviewed and graded the available evidence and developed evidence-based recommendations and consensus recommendations when insufficient evidence was available. Each consensus recommendation was voted upon by an anonymous process.

CONCLUSIONS

Vitamin D deficiency is common in CF. Given the limited evidence specific to CF, the committee provided consensus recommendations for most of the recommendations. The committee recommends yearly screening for vitamin D status, preferably at the end of winter, using the serum 25-hydroxyvitamin D measurement, with a minimal 25-hydroxyvitamin D concentration of 30 ng/ml (75 nmol/liter) considered vitamin D sufficient in individuals with CF. Recommendations for age-specific vitamin D intake for all individuals with CF, form of vitamin D, and a stepwise approach to increase vitamin D intake when optimal vitamin D status is not achieved are delineated.

Authors+Show Affiliations

Emory University, Atlanta, Georgia 30322, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Practice Guideline
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22399505

Citation

Tangpricha, V, et al. "An Update On the Screening, Diagnosis, Management, and Treatment of Vitamin D Deficiency in Individuals With Cystic Fibrosis: Evidence-based Recommendations From the Cystic Fibrosis Foundation." The Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 4, 2012, pp. 1082-93.
Tangpricha V, Kelly A, Stephenson A, et al. An update on the screening, diagnosis, management, and treatment of vitamin D deficiency in individuals with cystic fibrosis: evidence-based recommendations from the Cystic Fibrosis Foundation. J Clin Endocrinol Metab. 2012;97(4):1082-93.
Tangpricha, V., Kelly, A., Stephenson, A., Maguiness, K., Enders, J., Robinson, K. A., ... Borowitz, D. (2012). An update on the screening, diagnosis, management, and treatment of vitamin D deficiency in individuals with cystic fibrosis: evidence-based recommendations from the Cystic Fibrosis Foundation. The Journal of Clinical Endocrinology and Metabolism, 97(4), pp. 1082-93. doi:10.1210/jc.2011-3050.
Tangpricha V, et al. An Update On the Screening, Diagnosis, Management, and Treatment of Vitamin D Deficiency in Individuals With Cystic Fibrosis: Evidence-based Recommendations From the Cystic Fibrosis Foundation. J Clin Endocrinol Metab. 2012;97(4):1082-93. PubMed PMID: 22399505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An update on the screening, diagnosis, management, and treatment of vitamin D deficiency in individuals with cystic fibrosis: evidence-based recommendations from the Cystic Fibrosis Foundation. AU - Tangpricha,V, AU - Kelly,A, AU - Stephenson,A, AU - Maguiness,K, AU - Enders,J, AU - Robinson,K A, AU - Marshall,B C, AU - Borowitz,D, AU - ,, Y1 - 2012/03/07/ PY - 2012/3/9/entrez PY - 2012/3/9/pubmed PY - 2012/6/12/medline SP - 1082 EP - 93 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 97 IS - 4 N2 - OBJECTIVE: The objective was to develop evidence-based clinical care guidelines for the screening, diagnosis, management, and treatment of vitamin D deficiency in individuals with cystic fibrosis (CF). PARTICIPANTS: The guidelines committee was comprised of physicians, registered dietitians, a pharmacist, a nurse, a parent of an individual with CF, and a health scientist, all with experience in CF. PROCESS: Committee members developed questions specific to vitamin D health in individuals with CF. Systematic reviews were completed for each question. The committee reviewed and graded the available evidence and developed evidence-based recommendations and consensus recommendations when insufficient evidence was available. Each consensus recommendation was voted upon by an anonymous process. CONCLUSIONS: Vitamin D deficiency is common in CF. Given the limited evidence specific to CF, the committee provided consensus recommendations for most of the recommendations. The committee recommends yearly screening for vitamin D status, preferably at the end of winter, using the serum 25-hydroxyvitamin D measurement, with a minimal 25-hydroxyvitamin D concentration of 30 ng/ml (75 nmol/liter) considered vitamin D sufficient in individuals with CF. Recommendations for age-specific vitamin D intake for all individuals with CF, form of vitamin D, and a stepwise approach to increase vitamin D intake when optimal vitamin D status is not achieved are delineated. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/22399505/full_citation L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2011-3050 DB - PRIME DP - Unbound Medicine ER -