Prime

Type your tag names separated by a space and hit enter

Modifying effects of alcohol on the postprandial glucose and insulin responses in healthy subjects.

Abstract

BACKGROUND

Moderate alcohol consumption associates with lower risk of type 2 diabetes, but in postprandial studies, alcohol induced impaired insulin sensitivity. The measurement of the glycemic index (GI) for beer has been considered challenging because of its low carbohydrate content. Therefore, imputed GI values from 36 to 95 on the basis of carbohydrate-rich beverages have been used for beer in epidemiologic studies.

OBJECTIVES

We investigated the acute effects of alcohol on glucose and insulin responses and measured GIs and insulinemic indexes (IIs) of nonalcoholic and alcoholic beers.

DESIGN

In a crossover design, 10 healthy volunteers were served beer with 4.5% alcohol by volume, nonalcoholic beer, and a glucose solution with alcohol once and the reference glucose solution twice. Each portion contained 25 g available carbohydrate, and the beer and glucose solution with alcohol contained 21 g alcohol. Capillary blood samples were collected up to 2 h after ingestion, and the incremental AUCs (IAUCs), GIs, and IIs were calculated.

RESULTS

Compared with the reference glucose solution, the glucose solution with alcohol produced an 18% higher postprandial glucose IAUC (P = 0.03) and had no significant effect on the insulin IAUC. Compared with the reference glucose solution, beer had no significant effect on glucose or insulin IAUCs, and nonalcoholic beer tended to reduce the glucose IAUC (P = 0.06) but not the insulin IAUC. GIs of beer and nonalcoholic beer were 119 and 80, and IIs were 130 and 88, respectively.

CONCLUSIONS

Alcohol increases the postprandial glucose response, probably through impaired insulin sensitivity. GI values published for alcohol-containing beers have underestimated the true glycemic effects.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Departments of Lifestyle and Participation, National Institute for Health and Welfare, Helsinki, Finland. katja.hatonen@thl.fi

    , , , , ,

    Source

    MeSH

    Adult
    Alcohol Drinking
    Beer
    Beverages
    Blood Glucose
    Cross-Over Studies
    Dietary Carbohydrates
    Ethanol
    Female
    Finland
    Glycemic Index
    Humans
    Insulin
    Insulin Resistance
    Male
    Middle Aged
    Postprandial Period

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22648716

    Citation

    TY - JOUR T1 - Modifying effects of alcohol on the postprandial glucose and insulin responses in healthy subjects. AU - Hätönen,Katja A, AU - Virtamo,Jarmo, AU - Eriksson,Johan G, AU - Perälä,Mia-Maria, AU - Sinkko,Harri K, AU - Leiviskä,Jaana, AU - Valsta,Liisa M, Y1 - 2012/05/30/ PY - 2012/5/30/aheadofprint PY - 2012/6/1/entrez PY - 2012/6/1/pubmed PY - 2012/9/8/medline SP - 44 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 96 IS - 1 N2 - BACKGROUND: Moderate alcohol consumption associates with lower risk of type 2 diabetes, but in postprandial studies, alcohol induced impaired insulin sensitivity. The measurement of the glycemic index (GI) for beer has been considered challenging because of its low carbohydrate content. Therefore, imputed GI values from 36 to 95 on the basis of carbohydrate-rich beverages have been used for beer in epidemiologic studies. OBJECTIVES: We investigated the acute effects of alcohol on glucose and insulin responses and measured GIs and insulinemic indexes (IIs) of nonalcoholic and alcoholic beers. DESIGN: In a crossover design, 10 healthy volunteers were served beer with 4.5% alcohol by volume, nonalcoholic beer, and a glucose solution with alcohol once and the reference glucose solution twice. Each portion contained 25 g available carbohydrate, and the beer and glucose solution with alcohol contained 21 g alcohol. Capillary blood samples were collected up to 2 h after ingestion, and the incremental AUCs (IAUCs), GIs, and IIs were calculated. RESULTS: Compared with the reference glucose solution, the glucose solution with alcohol produced an 18% higher postprandial glucose IAUC (P = 0.03) and had no significant effect on the insulin IAUC. Compared with the reference glucose solution, beer had no significant effect on glucose or insulin IAUCs, and nonalcoholic beer tended to reduce the glucose IAUC (P = 0.06) but not the insulin IAUC. GIs of beer and nonalcoholic beer were 119 and 80, and IIs were 130 and 88, respectively. CONCLUSIONS: Alcohol increases the postprandial glucose response, probably through impaired insulin sensitivity. GI values published for alcohol-containing beers have underestimated the true glycemic effects. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22648716/full_citation L2 - http://www.ajcn.org/cgi/pmidlookup?view=long&pmid=22648716 ER -