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The effects of dietary intervention on HIV dyslipidaemia: a systematic review and meta-analysis.

Abstract

BACKGROUND

Efficacy of dietary intervention for treatment and prevention of HIV-related lipid disturbances has not been well established.

METHODS

We conducted a systematic search of electronic databases supplemented with manual searches and conference abstracts, without language restriction. All randomised controlled trials (RCTs) with blood lipid outcomes, involving dietary intervention or supplementation for the treatment or prevention of adult HIV dyslipidaemia, versus no or other intervention were included. Two authors using predefined data fields, including study quality indicators, extracted data independently.

RESULTS

Eighteen studies (n = 873) met our inclusion criteria. Seven RCTs for omega-3 supplementation (n = 372), and four RCTs for dietary intervention (n = 201) were meta-analysed using random-effects models. Mild statistical heterogeneity was observed. Dietary intervention reduced triglyceride levels by -0·46 mmol/l (95%CI: -0·85 to -0·07 mmol/l) compared to control. Omega-3 supplementation reduced triglyceride levels by -1.12 mmol/l, (95%CI: -1·57 to -0·67 mmol/l) and total cholesterol, -0·36 mmol/l (95%CI: -0·67 to -0·05 mmol/l) compared to placebo/control.

CONCLUSIONS

Both omega-3 supplementation and dietary intervention reduced triglyceride level, with the latter possibly to a smaller extent. While dietary interventions are beneficial, more stringent dietary approaches may be necessary to fully address lipid disturbances in HIV patients.

TRIAL REGISTRATION

PROSPERO 2011:CRD42011001329.

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  • Authors+Show Affiliations

    ,

    HIV Metabolic Clinic, Heart of England NHS Foundation Trust, Birmingham, United Kingdom. clare.stradling@heartofengland.nhs.uk

    , , , ,

    Source

    PloS one 7:6 2012 pg e38121

    MeSH

    Cholesterol
    Dietary Supplements
    Dyslipidemias
    Fatty Acids, Omega-3
    HIV Infections
    Humans
    Models, Statistical
    Randomized Controlled Trials as Topic
    Treatment Outcome
    Triglycerides

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    22701607

    Citation

    Stradling, Clare, et al. "The Effects of Dietary Intervention On HIV Dyslipidaemia: a Systematic Review and Meta-analysis." PloS One, vol. 7, no. 6, 2012, pp. e38121.
    Stradling C, Chen YF, Russell T, et al. The effects of dietary intervention on HIV dyslipidaemia: a systematic review and meta-analysis. PLoS ONE. 2012;7(6):e38121.
    Stradling, C., Chen, Y. F., Russell, T., Connock, M., Thomas, G. N., & Taheri, S. (2012). The effects of dietary intervention on HIV dyslipidaemia: a systematic review and meta-analysis. PloS One, 7(6), pp. e38121. doi:10.1371/journal.pone.0038121.
    Stradling C, et al. The Effects of Dietary Intervention On HIV Dyslipidaemia: a Systematic Review and Meta-analysis. PLoS ONE. 2012;7(6):e38121. PubMed PMID: 22701607.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The effects of dietary intervention on HIV dyslipidaemia: a systematic review and meta-analysis. AU - Stradling,Clare, AU - Chen,Yen-Fu, AU - Russell,Tracy, AU - Connock,Martin, AU - Thomas,G Neil, AU - Taheri,Shahrad, Y1 - 2012/06/11/ PY - 2012/03/02/received PY - 2012/05/01/accepted PY - 2012/6/16/entrez PY - 2012/6/16/pubmed PY - 2012/11/9/medline SP - e38121 EP - e38121 JF - PloS one JO - PLoS ONE VL - 7 IS - 6 N2 - BACKGROUND: Efficacy of dietary intervention for treatment and prevention of HIV-related lipid disturbances has not been well established. METHODS: We conducted a systematic search of electronic databases supplemented with manual searches and conference abstracts, without language restriction. All randomised controlled trials (RCTs) with blood lipid outcomes, involving dietary intervention or supplementation for the treatment or prevention of adult HIV dyslipidaemia, versus no or other intervention were included. Two authors using predefined data fields, including study quality indicators, extracted data independently. RESULTS: Eighteen studies (n = 873) met our inclusion criteria. Seven RCTs for omega-3 supplementation (n = 372), and four RCTs for dietary intervention (n = 201) were meta-analysed using random-effects models. Mild statistical heterogeneity was observed. Dietary intervention reduced triglyceride levels by -0·46 mmol/l (95%CI: -0·85 to -0·07 mmol/l) compared to control. Omega-3 supplementation reduced triglyceride levels by -1.12 mmol/l, (95%CI: -1·57 to -0·67 mmol/l) and total cholesterol, -0·36 mmol/l (95%CI: -0·67 to -0·05 mmol/l) compared to placebo/control. CONCLUSIONS: Both omega-3 supplementation and dietary intervention reduced triglyceride level, with the latter possibly to a smaller extent. While dietary interventions are beneficial, more stringent dietary approaches may be necessary to fully address lipid disturbances in HIV patients. TRIAL REGISTRATION: PROSPERO 2011:CRD42011001329. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/22701607/full_citation L2 - http://dx.plos.org/10.1371/journal.pone.0038121 DB - PRIME DP - Unbound Medicine ER -