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Oxidative stress biomarkers in patients with endometriosis: systematic review.

Abstract

PURPOSE

Since the first description about oxygen toxicity made by Joseph Priestley, the oxidative stress has been enrolled as a key factor in the pathogenesis of endometriosis. Our aim was to review oxidative stress biomarkers measured in patients with endometriosis.

METHODS

Relevant studies were identified by searches of the MEDLINE database from 1990 to March 2011 using endometriosis, free radical and oxidative stress as mesh terms. We only included manuscripts in English, and review articles were excluded. In addition, free radical chemistry and oxidative stress history were discussed.

RESULTS

After inclusion and exclusion criteria, 19 articles were selected to be included in this systematic review. A total of 36 oxidative stress biomarkers (20 different markers) were measured in patients with endometriosis. Some of the markers were measured in more than one manuscript. They were arranged in five subgroups: Enzymatic activity (n = 3), Anions/free radicals (n = 5), Lipoperoxidation markers (n = 7), DNA Damage markers (n = 1), and Protein oxidation (n = 4). Of those 36 markers, 23 were found to be significantly higher in patients with endometriosis comparing with control patients.

CONCLUSION

Oxidative stress plays an important role in the pathogenesis and progression of endometriosis.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Center for Reproductive Medicine, Obstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, Ohio 44195, USA. luizcarvalho.dr@me.com

    , , ,

    Source

    Archives of gynecology and obstetrics 286:4 2012 Oct pg 1033-40

    MeSH

    Biomarkers
    Endometriosis
    Female
    Humans
    Oxidative Stress

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    22791380

    Citation

    Carvalho, Luiz Fernando Pina, et al. "Oxidative Stress Biomarkers in Patients With Endometriosis: Systematic Review." Archives of Gynecology and Obstetrics, vol. 286, no. 4, 2012, pp. 1033-40.
    Carvalho LF, Samadder AN, Agarwal A, et al. Oxidative stress biomarkers in patients with endometriosis: systematic review. Arch Gynecol Obstet. 2012;286(4):1033-40.
    Carvalho, L. F., Samadder, A. N., Agarwal, A., Fernandes, L. F., & Abrão, M. S. (2012). Oxidative stress biomarkers in patients with endometriosis: systematic review. Archives of Gynecology and Obstetrics, 286(4), pp. 1033-40. doi:10.1007/s00404-012-2439-7.
    Carvalho LF, et al. Oxidative Stress Biomarkers in Patients With Endometriosis: Systematic Review. Arch Gynecol Obstet. 2012;286(4):1033-40. PubMed PMID: 22791380.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oxidative stress biomarkers in patients with endometriosis: systematic review. AU - Carvalho,Luiz Fernando Pina, AU - Samadder,Abhishek Neil, AU - Agarwal,Ashok, AU - Fernandes,Luiz Flávio C, AU - Abrão,Mauricio S, Y1 - 2012/07/12/ PY - 2011/12/09/received PY - 2012/06/18/accepted PY - 2012/7/14/entrez PY - 2012/7/14/pubmed PY - 2013/2/8/medline SP - 1033 EP - 40 JF - Archives of gynecology and obstetrics JO - Arch. Gynecol. Obstet. VL - 286 IS - 4 N2 - PURPOSE: Since the first description about oxygen toxicity made by Joseph Priestley, the oxidative stress has been enrolled as a key factor in the pathogenesis of endometriosis. Our aim was to review oxidative stress biomarkers measured in patients with endometriosis. METHODS: Relevant studies were identified by searches of the MEDLINE database from 1990 to March 2011 using endometriosis, free radical and oxidative stress as mesh terms. We only included manuscripts in English, and review articles were excluded. In addition, free radical chemistry and oxidative stress history were discussed. RESULTS: After inclusion and exclusion criteria, 19 articles were selected to be included in this systematic review. A total of 36 oxidative stress biomarkers (20 different markers) were measured in patients with endometriosis. Some of the markers were measured in more than one manuscript. They were arranged in five subgroups: Enzymatic activity (n = 3), Anions/free radicals (n = 5), Lipoperoxidation markers (n = 7), DNA Damage markers (n = 1), and Protein oxidation (n = 4). Of those 36 markers, 23 were found to be significantly higher in patients with endometriosis comparing with control patients. CONCLUSION: Oxidative stress plays an important role in the pathogenesis and progression of endometriosis. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/22791380/full_citation L2 - https://dx.doi.org/10.1007/s00404-012-2439-7 DB - PRIME DP - Unbound Medicine ER -