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Flavonoid intake and bone health.

Abstract

Flavonoids, found in a wide diversity of plant foods from fruits and vegetables, herbs and spices, essential oils, and beverages, have the most potential of dietary components for promotion of bone health beyond calcium and vitamin D. Recent epidemiological studies show flavonoid consumption to have a stronger association with bone than general fruit and vegetable consumption. Bioactive flavonoids are being assessed for properties beyond their chemical antioxidant capacity, including anti-inflammatory actions. Some have been reported to enhance bone formation and to inhibit bone resorption through their action on cell signaling pathways that influence osteoblast and osteoclast differentiation. Future research is needed to determine which of the flavonoids and their metabolites are most effective and at what dose, as well as the mechanism of modulating cellular events, in order to set priorities for clinical trials.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition Science, Purdue University, West Lafayette, Indiana 47907-2059, USA. weavercm@purdue.edu

    , ,

    Source

    MeSH

    Anti-Inflammatory Agents
    Bone Resorption
    Bone and Bones
    Diet
    Flavonoids
    Humans
    Osteoblasts
    Osteoclasts
    Osteogenesis
    Osteoporosis
    Phytotherapy
    Plant Extracts
    Signal Transduction

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    22888840

    Citation

    Weaver, Connie M., et al. "Flavonoid Intake and Bone Health." Journal of Nutrition in Gerontology and Geriatrics, vol. 31, no. 3, 2012, pp. 239-53.
    Weaver CM, Alekel DL, Ward WE, et al. Flavonoid intake and bone health. J Nutr Gerontol Geriatr. 2012;31(3):239-53.
    Weaver, C. M., Alekel, D. L., Ward, W. E., & Ronis, M. J. (2012). Flavonoid intake and bone health. Journal of Nutrition in Gerontology and Geriatrics, 31(3), pp. 239-53. doi:10.1080/21551197.2012.698220.
    Weaver CM, et al. Flavonoid Intake and Bone Health. J Nutr Gerontol Geriatr. 2012;31(3):239-53. PubMed PMID: 22888840.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Flavonoid intake and bone health. AU - Weaver,Connie M, AU - Alekel,D Lee, AU - Ward,Wendy E, AU - Ronis,Martin J, PY - 2012/8/15/entrez PY - 2012/8/15/pubmed PY - 2012/12/18/medline SP - 239 EP - 53 JF - Journal of nutrition in gerontology and geriatrics JO - J Nutr Gerontol Geriatr VL - 31 IS - 3 N2 - Flavonoids, found in a wide diversity of plant foods from fruits and vegetables, herbs and spices, essential oils, and beverages, have the most potential of dietary components for promotion of bone health beyond calcium and vitamin D. Recent epidemiological studies show flavonoid consumption to have a stronger association with bone than general fruit and vegetable consumption. Bioactive flavonoids are being assessed for properties beyond their chemical antioxidant capacity, including anti-inflammatory actions. Some have been reported to enhance bone formation and to inhibit bone resorption through their action on cell signaling pathways that influence osteoblast and osteoclast differentiation. Future research is needed to determine which of the flavonoids and their metabolites are most effective and at what dose, as well as the mechanism of modulating cellular events, in order to set priorities for clinical trials. SN - 2155-1200 UR - https://www.unboundmedicine.com/medline/citation/22888840/full_citation L2 - http://www.tandfonline.com/doi/full/10.1080/21551197.2012.698220 DB - PRIME DP - Unbound Medicine ER -