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Flavonoid intake and bone health.
J Nutr Gerontol Geriatr 2012; 31(3):239-53JN

Abstract

Flavonoids, found in a wide diversity of plant foods from fruits and vegetables, herbs and spices, essential oils, and beverages, have the most potential of dietary components for promotion of bone health beyond calcium and vitamin D. Recent epidemiological studies show flavonoid consumption to have a stronger association with bone than general fruit and vegetable consumption. Bioactive flavonoids are being assessed for properties beyond their chemical antioxidant capacity, including anti-inflammatory actions. Some have been reported to enhance bone formation and to inhibit bone resorption through their action on cell signaling pathways that influence osteoblast and osteoclast differentiation. Future research is needed to determine which of the flavonoids and their metabolites are most effective and at what dose, as well as the mechanism of modulating cellular events, in order to set priorities for clinical trials.

Authors+Show Affiliations

Department of Nutrition Science, Purdue University, West Lafayette, Indiana 47907-2059, USA. weavercm@purdue.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22888840

Citation

Weaver, Connie M., et al. "Flavonoid Intake and Bone Health." Journal of Nutrition in Gerontology and Geriatrics, vol. 31, no. 3, 2012, pp. 239-53.
Weaver CM, Alekel DL, Ward WE, et al. Flavonoid intake and bone health. J Nutr Gerontol Geriatr. 2012;31(3):239-53.
Weaver, C. M., Alekel, D. L., Ward, W. E., & Ronis, M. J. (2012). Flavonoid intake and bone health. Journal of Nutrition in Gerontology and Geriatrics, 31(3), pp. 239-53. doi:10.1080/21551197.2012.698220.
Weaver CM, et al. Flavonoid Intake and Bone Health. J Nutr Gerontol Geriatr. 2012;31(3):239-53. PubMed PMID: 22888840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavonoid intake and bone health. AU - Weaver,Connie M, AU - Alekel,D Lee, AU - Ward,Wendy E, AU - Ronis,Martin J, PY - 2012/8/15/entrez PY - 2012/8/15/pubmed PY - 2012/12/18/medline SP - 239 EP - 53 JF - Journal of nutrition in gerontology and geriatrics JO - J Nutr Gerontol Geriatr VL - 31 IS - 3 N2 - Flavonoids, found in a wide diversity of plant foods from fruits and vegetables, herbs and spices, essential oils, and beverages, have the most potential of dietary components for promotion of bone health beyond calcium and vitamin D. Recent epidemiological studies show flavonoid consumption to have a stronger association with bone than general fruit and vegetable consumption. Bioactive flavonoids are being assessed for properties beyond their chemical antioxidant capacity, including anti-inflammatory actions. Some have been reported to enhance bone formation and to inhibit bone resorption through their action on cell signaling pathways that influence osteoblast and osteoclast differentiation. Future research is needed to determine which of the flavonoids and their metabolites are most effective and at what dose, as well as the mechanism of modulating cellular events, in order to set priorities for clinical trials. SN - 2155-1200 UR - https://www.unboundmedicine.com/medline/citation/22888840/full_citation L2 - http://www.tandfonline.com/doi/full/10.1080/21551197.2012.698220 DB - PRIME DP - Unbound Medicine ER -