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Autonomic dysfunction in parkinsonian disorders: assessment and pathophysiology.

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by motor dysfunction (parkinsonism) and several non-motor features. Dysautonomia is a significant non-motor feature as well as a neuropsychiatric symptom. Autonomic dysfunction can occur even in the early stages of PD, often preceding the onset of the classic motor symptoms of PD. The patterns of autonomic features in PD are different from other parkinsonian disorders. Detection of autonomic dysfunction may therefore be helpful in diagnosing PD in the early or pre-motor stages, and/or in differentiating it from other parkinsonian disorders, such as multiple system atrophy and progressive supuranuclear palsy. The aim of this review is to describe aspects of autonomic dysfunction, including symptoms, assessment and pathophysiology, resulting from autonomic impairment in PD and other parkinsonian syndromes.

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    MeSH

    Antiparkinson Agents
    Autonomic Nervous System
    Cardiovascular System
    Gastrointestinal Diseases
    Humans
    Hypotension, Orthostatic
    Parkinsonian Disorders

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    22942216

    Citation

    TY - JOUR T1 - Autonomic dysfunction in parkinsonian disorders: assessment and pathophysiology. AU - Asahina,Masato, AU - Vichayanrat,Ekawat, AU - Low,David A, AU - Iodice,Valeria, AU - Mathias,Christopher J, Y1 - 2012/09/01/ PY - 2012/9/1/aheadofprint PY - 2012/10/15/aheadofprint PY - 2012/9/4/entrez PY - 2012/9/4/pubmed PY - 2013/7/16/medline SP - 674 EP - 80 JF - Journal of neurology, neurosurgery, and psychiatry JO - J. Neurol. Neurosurg. Psychiatr. VL - 84 IS - 6 N2 - Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by motor dysfunction (parkinsonism) and several non-motor features. Dysautonomia is a significant non-motor feature as well as a neuropsychiatric symptom. Autonomic dysfunction can occur even in the early stages of PD, often preceding the onset of the classic motor symptoms of PD. The patterns of autonomic features in PD are different from other parkinsonian disorders. Detection of autonomic dysfunction may therefore be helpful in diagnosing PD in the early or pre-motor stages, and/or in differentiating it from other parkinsonian disorders, such as multiple system atrophy and progressive supuranuclear palsy. The aim of this review is to describe aspects of autonomic dysfunction, including symptoms, assessment and pathophysiology, resulting from autonomic impairment in PD and other parkinsonian syndromes. SN - 1468-330X UR - https://www.unboundmedicine.com/medline/citation/22942216/full_citation L2 - http://jnnp.bmj.com/cgi/pmidlookup?view=long&pmid=22942216 ER -