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Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium.

Abstract

To clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia, and tuberculosis) in the development of lung cancer, the authors conducted a pooled analysis of studies in the International Lung Cancer Consortium. Seventeen studies including 24,607 cases and 81,829 controls (noncases), mainly conducted in Europe and North America, were included (1984-2011). Using self-reported data on previous diagnoses of lung diseases, the authors derived study-specific effect estimates by means of logistic regression models or Cox proportional hazards models adjusted for age, sex, and cumulative tobacco smoking. Estimates were pooled using random-effects models. Analyses stratified by smoking status and histology were also conducted. A history of emphysema conferred a 2.44-fold increased risk of lung cancer (95% confidence interval (CI): 1.64, 3.62 (16 studies)). A history of chronic bronchitis conferred a relative risk of 1.47 (95% CI: 1.29, 1.68 (13 studies)). Tuberculosis (relative risk = 1.48, 95% CI: 1.17, 1.87 (16 studies)) and pneumonia (relative risk = 1.57, 95% CI: 1.22, 2.01 (12 studies)) were also associated with lung cancer risk. Among never smokers, elevated risks were observed for emphysema, pneumonia, and tuberculosis. These results suggest that previous lung diseases influence lung cancer risk independently of tobacco use and that these diseases are important for assessing individual risk.

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    ,

    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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    Source

    American journal of epidemiology 176:7 2012 Oct 01 pg 573-85

    MeSH

    Bronchitis, Chronic
    Humans
    Logistic Models
    Lung Neoplasms
    Pneumonia
    Proportional Hazards Models
    Pulmonary Emphysema
    Risk
    Risk Factors
    Self Report
    Tuberculosis, Pulmonary

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22986146

    Citation

    Brenner, Darren R., et al. "Previous Lung Diseases and Lung Cancer Risk: a Pooled Analysis From the International Lung Cancer Consortium." American Journal of Epidemiology, vol. 176, no. 7, 2012, pp. 573-85.
    Brenner DR, Boffetta P, Duell EJ, et al. Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium. Am J Epidemiol. 2012;176(7):573-85.
    Brenner, D. R., Boffetta, P., Duell, E. J., Bickeböller, H., Rosenberger, A., McCormack, V., ... Hung, R. J. (2012). Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium. American Journal of Epidemiology, 176(7), pp. 573-85.
    Brenner DR, et al. Previous Lung Diseases and Lung Cancer Risk: a Pooled Analysis From the International Lung Cancer Consortium. Am J Epidemiol. 2012 Oct 1;176(7):573-85. PubMed PMID: 22986146.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium. AU - Brenner,Darren R, AU - Boffetta,Paolo, AU - Duell,Eric J, AU - Bickeböller,Heike, AU - Rosenberger,Albert, AU - McCormack,Valerie, AU - Muscat,Joshua E, AU - Yang,Ping, AU - Wichmann,H-Erich, AU - Brueske-Hohlfeld,Irene, AU - Schwartz,Ann G, AU - Cote,Michele L, AU - Tjønneland,Anne, AU - Friis,Søren, AU - Le Marchand,Loic, AU - Zhang,Zuo-Feng, AU - Morgenstern,Hal, AU - Szeszenia-Dabrowska,Neonila, AU - Lissowska,Jolanta, AU - Zaridze,David, AU - Rudnai,Peter, AU - Fabianova,Eleonora, AU - Foretova,Lenka, AU - Janout,Vladimir, AU - Bencko,Vladimir, AU - Schejbalova,Miriam, AU - Brennan,Paul, AU - Mates,Ioan N, AU - Lazarus,Philip, AU - Field,John K, AU - Raji,Olaide, AU - McLaughlin,John R, AU - Liu,Geoffrey, AU - Wiencke,John, AU - Neri,Monica, AU - Ugolini,Donatella, AU - Andrew,Angeline S, AU - Lan,Qing, AU - Hu,Wei, AU - Orlow,Irene, AU - Park,Bernard J, AU - Hung,Rayjean J, Y1 - 2012/09/17/ PY - 2012/9/19/entrez PY - 2012/9/19/pubmed PY - 2012/12/10/medline SP - 573 EP - 85 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 176 IS - 7 N2 - To clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia, and tuberculosis) in the development of lung cancer, the authors conducted a pooled analysis of studies in the International Lung Cancer Consortium. Seventeen studies including 24,607 cases and 81,829 controls (noncases), mainly conducted in Europe and North America, were included (1984-2011). Using self-reported data on previous diagnoses of lung diseases, the authors derived study-specific effect estimates by means of logistic regression models or Cox proportional hazards models adjusted for age, sex, and cumulative tobacco smoking. Estimates were pooled using random-effects models. Analyses stratified by smoking status and histology were also conducted. A history of emphysema conferred a 2.44-fold increased risk of lung cancer (95% confidence interval (CI): 1.64, 3.62 (16 studies)). A history of chronic bronchitis conferred a relative risk of 1.47 (95% CI: 1.29, 1.68 (13 studies)). Tuberculosis (relative risk = 1.48, 95% CI: 1.17, 1.87 (16 studies)) and pneumonia (relative risk = 1.57, 95% CI: 1.22, 2.01 (12 studies)) were also associated with lung cancer risk. Among never smokers, elevated risks were observed for emphysema, pneumonia, and tuberculosis. These results suggest that previous lung diseases influence lung cancer risk independently of tobacco use and that these diseases are important for assessing individual risk. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/22986146/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kws151 DB - PRIME DP - Unbound Medicine ER -