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Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium.
Am J Epidemiol 2012; 176(7):573-85AJ

Abstract

To clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia, and tuberculosis) in the development of lung cancer, the authors conducted a pooled analysis of studies in the International Lung Cancer Consortium. Seventeen studies including 24,607 cases and 81,829 controls (noncases), mainly conducted in Europe and North America, were included (1984-2011). Using self-reported data on previous diagnoses of lung diseases, the authors derived study-specific effect estimates by means of logistic regression models or Cox proportional hazards models adjusted for age, sex, and cumulative tobacco smoking. Estimates were pooled using random-effects models. Analyses stratified by smoking status and histology were also conducted. A history of emphysema conferred a 2.44-fold increased risk of lung cancer (95% confidence interval (CI): 1.64, 3.62 (16 studies)). A history of chronic bronchitis conferred a relative risk of 1.47 (95% CI: 1.29, 1.68 (13 studies)). Tuberculosis (relative risk = 1.48, 95% CI: 1.17, 1.87 (16 studies)) and pneumonia (relative risk = 1.57, 95% CI: 1.22, 2.01 (12 studies)) were also associated with lung cancer risk. Among never smokers, elevated risks were observed for emphysema, pneumonia, and tuberculosis. These results suggest that previous lung diseases influence lung cancer risk independently of tobacco use and that these diseases are important for assessing individual risk.

Authors+Show Affiliations

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22986146

Citation

Brenner, Darren R., et al. "Previous Lung Diseases and Lung Cancer Risk: a Pooled Analysis From the International Lung Cancer Consortium." American Journal of Epidemiology, vol. 176, no. 7, 2012, pp. 573-85.
Brenner DR, Boffetta P, Duell EJ, et al. Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium. Am J Epidemiol. 2012;176(7):573-85.
Brenner, D. R., Boffetta, P., Duell, E. J., Bickeböller, H., Rosenberger, A., McCormack, V., ... Hung, R. J. (2012). Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium. American Journal of Epidemiology, 176(7), pp. 573-85.
Brenner DR, et al. Previous Lung Diseases and Lung Cancer Risk: a Pooled Analysis From the International Lung Cancer Consortium. Am J Epidemiol. 2012 Oct 1;176(7):573-85. PubMed PMID: 22986146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium. AU - Brenner,Darren R, AU - Boffetta,Paolo, AU - Duell,Eric J, AU - Bickeböller,Heike, AU - Rosenberger,Albert, AU - McCormack,Valerie, AU - Muscat,Joshua E, AU - Yang,Ping, AU - Wichmann,H-Erich, AU - Brueske-Hohlfeld,Irene, AU - Schwartz,Ann G, AU - Cote,Michele L, AU - Tjønneland,Anne, AU - Friis,Søren, AU - Le Marchand,Loic, AU - Zhang,Zuo-Feng, AU - Morgenstern,Hal, AU - Szeszenia-Dabrowska,Neonila, AU - Lissowska,Jolanta, AU - Zaridze,David, AU - Rudnai,Peter, AU - Fabianova,Eleonora, AU - Foretova,Lenka, AU - Janout,Vladimir, AU - Bencko,Vladimir, AU - Schejbalova,Miriam, AU - Brennan,Paul, AU - Mates,Ioan N, AU - Lazarus,Philip, AU - Field,John K, AU - Raji,Olaide, AU - McLaughlin,John R, AU - Liu,Geoffrey, AU - Wiencke,John, AU - Neri,Monica, AU - Ugolini,Donatella, AU - Andrew,Angeline S, AU - Lan,Qing, AU - Hu,Wei, AU - Orlow,Irene, AU - Park,Bernard J, AU - Hung,Rayjean J, Y1 - 2012/09/17/ PY - 2012/9/19/entrez PY - 2012/9/19/pubmed PY - 2012/12/10/medline SP - 573 EP - 85 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 176 IS - 7 N2 - To clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia, and tuberculosis) in the development of lung cancer, the authors conducted a pooled analysis of studies in the International Lung Cancer Consortium. Seventeen studies including 24,607 cases and 81,829 controls (noncases), mainly conducted in Europe and North America, were included (1984-2011). Using self-reported data on previous diagnoses of lung diseases, the authors derived study-specific effect estimates by means of logistic regression models or Cox proportional hazards models adjusted for age, sex, and cumulative tobacco smoking. Estimates were pooled using random-effects models. Analyses stratified by smoking status and histology were also conducted. A history of emphysema conferred a 2.44-fold increased risk of lung cancer (95% confidence interval (CI): 1.64, 3.62 (16 studies)). A history of chronic bronchitis conferred a relative risk of 1.47 (95% CI: 1.29, 1.68 (13 studies)). Tuberculosis (relative risk = 1.48, 95% CI: 1.17, 1.87 (16 studies)) and pneumonia (relative risk = 1.57, 95% CI: 1.22, 2.01 (12 studies)) were also associated with lung cancer risk. Among never smokers, elevated risks were observed for emphysema, pneumonia, and tuberculosis. These results suggest that previous lung diseases influence lung cancer risk independently of tobacco use and that these diseases are important for assessing individual risk. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/22986146/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kws151 DB - PRIME DP - Unbound Medicine ER -