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Whole milk intake is associated with prostate cancer-specific mortality among U.S. male physicians.

Abstract

Previous studies have associated higher milk intake with greater prostate cancer (PCa) incidence, but little data are available concerning milk types and the relation between milk intake and risk of fatal PCa. We investigated the association between intake of dairy products and the incidence and survival of PCa during a 28-y follow-up. We conducted a cohort study in the Physicians' Health Study (n = 21,660) and a survival analysis among the incident PCa cases (n = 2806). Information on dairy product consumption was collected at baseline. PCa cases and deaths (n = 305) were confirmed during follow-up. The intake of total dairy products was associated with increased PCa incidence [HR = 1.12 (95% CI: 0.93, 1.35); >2.5 servings/d vs. ≤0.5 servings/d]. Skim/low-fat milk intake was positively associated with risk of low-grade, early stage, and screen-detected cancers, whereas whole milk intake was associated only with fatal PCa [HR = 1.49 (95% CI: 0.97, 2.28); ≥237 mL/d (1 serving/d) vs. rarely consumed]. In the survival analysis, whole milk intake remained associated with risk of progression to fatal disease after diagnosis [HR = 2.17 (95% CI: 1.34, 3.51)]. In this prospective cohort, higher intake of skim/low-fat milk was associated with a greater risk of nonaggressive PCa. Most importantly, only whole milk was consistently associated with higher incidence of fatal PCa in the entire cohort and higher PCa-specific mortality among cases. These findings add further evidence to suggest the potential role of dairy products in the development and prognosis of PCa.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Program on Genomics and Nutrition, Fielding School of Public Health, University of California-Los Angeles, Los Angeles, CA, USA.

    , , , , , , , , ,

    Source

    The Journal of nutrition 143:2 2013 Feb pg 189-96

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Animals
    Cohort Studies
    Dairy Products
    Diet, Fat-Restricted
    Dietary Fats
    Follow-Up Studies
    Humans
    Incidence
    Male
    Middle Aged
    Milk
    Physicians
    Prognosis
    Prostatic Neoplasms
    Surveys and Questionnaires
    Survival Analysis
    United States

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23256145

    Citation

    Song, Yan, et al. "Whole Milk Intake Is Associated With Prostate Cancer-specific Mortality Among U.S. Male Physicians." The Journal of Nutrition, vol. 143, no. 2, 2013, pp. 189-96.
    Song Y, Chavarro JE, Cao Y, et al. Whole milk intake is associated with prostate cancer-specific mortality among U.S. male physicians. J Nutr. 2013;143(2):189-96.
    Song, Y., Chavarro, J. E., Cao, Y., Qiu, W., Mucci, L., Sesso, H. D., ... Ma, J. (2013). Whole milk intake is associated with prostate cancer-specific mortality among U.S. male physicians. The Journal of Nutrition, 143(2), pp. 189-96. doi:10.3945/jn.112.168484.
    Song Y, et al. Whole Milk Intake Is Associated With Prostate Cancer-specific Mortality Among U.S. Male Physicians. J Nutr. 2013;143(2):189-96. PubMed PMID: 23256145.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Whole milk intake is associated with prostate cancer-specific mortality among U.S. male physicians. AU - Song,Yan, AU - Chavarro,Jorge E, AU - Cao,Yin, AU - Qiu,Weiliang, AU - Mucci,Lorelei, AU - Sesso,Howard D, AU - Stampfer,Meir J, AU - Giovannucci,Edward, AU - Pollak,Michael, AU - Liu,Simin, AU - Ma,Jing, Y1 - 2012/12/19/ PY - 2012/12/21/entrez PY - 2012/12/21/pubmed PY - 2013/3/13/medline SP - 189 EP - 96 JF - The Journal of nutrition JO - J. Nutr. VL - 143 IS - 2 N2 - Previous studies have associated higher milk intake with greater prostate cancer (PCa) incidence, but little data are available concerning milk types and the relation between milk intake and risk of fatal PCa. We investigated the association between intake of dairy products and the incidence and survival of PCa during a 28-y follow-up. We conducted a cohort study in the Physicians' Health Study (n = 21,660) and a survival analysis among the incident PCa cases (n = 2806). Information on dairy product consumption was collected at baseline. PCa cases and deaths (n = 305) were confirmed during follow-up. The intake of total dairy products was associated with increased PCa incidence [HR = 1.12 (95% CI: 0.93, 1.35); >2.5 servings/d vs. ≤0.5 servings/d]. Skim/low-fat milk intake was positively associated with risk of low-grade, early stage, and screen-detected cancers, whereas whole milk intake was associated only with fatal PCa [HR = 1.49 (95% CI: 0.97, 2.28); ≥237 mL/d (1 serving/d) vs. rarely consumed]. In the survival analysis, whole milk intake remained associated with risk of progression to fatal disease after diagnosis [HR = 2.17 (95% CI: 1.34, 3.51)]. In this prospective cohort, higher intake of skim/low-fat milk was associated with a greater risk of nonaggressive PCa. Most importantly, only whole milk was consistently associated with higher incidence of fatal PCa in the entire cohort and higher PCa-specific mortality among cases. These findings add further evidence to suggest the potential role of dairy products in the development and prognosis of PCa. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/23256145/full_citation L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.112.168484 DB - PRIME DP - Unbound Medicine ER -