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Chronic kidney disease as a coronary artery disease risk equivalent.
Curr Cardiol Rep 2013; 15(3):340CC

Abstract

Chronic kidney disease (CKD) is associated with accelerated cardiovascular disease (CVD) risk and a higher CVD event rate. Substantial data from prospective cohort studies support the concept that dialysis patients as well as those with advanced stage (stages 3-5) CKD are associated with an increased risk for all-cause and cardiovascular mortality. The risk for coronary artery disease (CAD) increases exponentially with declining kidney function, i.e., stage 3 or higher CKD. Indeed, CVD accounts for more than 50 % of deaths in patients with CKD. CKD patients are more likely to die of CVD than to progress to end stage kidney disease. This increase in CV risk is commonly attributed to co-existence of numerous traditional and nontraditional risk factors for the development of CVD that frequently accompany reduced kidney function. Therefore, CKD itself is now considered an independent CVD risk factor and a coronary artery disease (CAD) equivalent for all-cause mortality. All patients at risk for CAD should be evaluated for kidney disease. Treatments used for management of established CAD might have similar benefits for patients with concomitant CKD.

Authors+Show Affiliations

ASH Comprehensive Hypertension Center, Department of Medicine, The University of Chicago Medicine, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23338722

Citation

Briasoulis, Alexandrios, and George L. Bakris. "Chronic Kidney Disease as a Coronary Artery Disease Risk Equivalent." Current Cardiology Reports, vol. 15, no. 3, 2013, p. 340.
Briasoulis A, Bakris GL. Chronic kidney disease as a coronary artery disease risk equivalent. Curr Cardiol Rep. 2013;15(3):340.
Briasoulis, A., & Bakris, G. L. (2013). Chronic kidney disease as a coronary artery disease risk equivalent. Current Cardiology Reports, 15(3), p. 340. doi:10.1007/s11886-012-0340-4.
Briasoulis A, Bakris GL. Chronic Kidney Disease as a Coronary Artery Disease Risk Equivalent. Curr Cardiol Rep. 2013;15(3):340. PubMed PMID: 23338722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic kidney disease as a coronary artery disease risk equivalent. AU - Briasoulis,Alexandrios, AU - Bakris,George L, PY - 2013/1/23/entrez PY - 2013/1/23/pubmed PY - 2013/6/29/medline SP - 340 EP - 340 JF - Current cardiology reports JO - Curr Cardiol Rep VL - 15 IS - 3 N2 - Chronic kidney disease (CKD) is associated with accelerated cardiovascular disease (CVD) risk and a higher CVD event rate. Substantial data from prospective cohort studies support the concept that dialysis patients as well as those with advanced stage (stages 3-5) CKD are associated with an increased risk for all-cause and cardiovascular mortality. The risk for coronary artery disease (CAD) increases exponentially with declining kidney function, i.e., stage 3 or higher CKD. Indeed, CVD accounts for more than 50 % of deaths in patients with CKD. CKD patients are more likely to die of CVD than to progress to end stage kidney disease. This increase in CV risk is commonly attributed to co-existence of numerous traditional and nontraditional risk factors for the development of CVD that frequently accompany reduced kidney function. Therefore, CKD itself is now considered an independent CVD risk factor and a coronary artery disease (CAD) equivalent for all-cause mortality. All patients at risk for CAD should be evaluated for kidney disease. Treatments used for management of established CAD might have similar benefits for patients with concomitant CKD. SN - 1534-3170 UR - https://www.unboundmedicine.com/medline/citation/23338722/full_citation L2 - https://dx.doi.org/10.1007/s11886-012-0340-4 DB - PRIME DP - Unbound Medicine ER -