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Dietary patterns and colorectal cancer recurrence and survival: a cohort study.

Abstract

OBJECTIVE

To examine the association between dietary patterns and colorectal cancer (CRC) survival.

DESIGN

Cohort study.

SETTING

A familial CRC registry in Newfoundland.

PARTICIPANTS

529 newly diagnosed CRC patients from Newfoundland. They were recruited from 1999 to 2003 and followed up until April 2010.

OUTCOME MEASURE

Participants reported their dietary intake using a food frequency questionnaire. Dietary patterns were identified with factor analysis. Multivariable Cox proportional hazards models were employed to estimate HR and 95% CI for association of dietary patterns with CRC recurrence and death from all causes, after controlling for covariates.

RESULTS

Disease-free survival (DFS) among CRC patients was significantly worsened among patients with a high processed meat dietary pattern (the highest vs the lowest quartile HR 1.82, 95% CI 1.07 to 3.09). No associations were observed with the prudent vegetable or the high-sugar patterns and DFS. The association between the processed meat pattern and DFS was restricted to patients diagnosed with colon cancer (the highest vs the lowest quartile: HR 2.29, 95% CI 1.19 to 4.40) whereas the relationship between overall survival (OS) and this pattern was observed among patients with colon cancer only (the highest vs the lowest quartile: HR 2.13, 95% CI 1.03 to 4.43). Potential effect modification was noted for sex (p value for interaction 0.04, HR 3.85 for women and 1.22 for men).

CONCLUSIONS

The processed meat dietary pattern prior to diagnosis is associated with higher risk of tumour recurrence, metastasis and death among patients with CRC.

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  • Authors+Show Affiliations

    ,

    Division of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.

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    Source

    BMJ open 3:2 2013 pg

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23396503

    Citation

    Zhu, Yun, et al. "Dietary Patterns and Colorectal Cancer Recurrence and Survival: a Cohort Study." BMJ Open, vol. 3, no. 2, 2013.
    Zhu Y, Wu H, Wang PP, et al. Dietary patterns and colorectal cancer recurrence and survival: a cohort study. BMJ Open. 2013;3(2).
    Zhu, Y., Wu, H., Wang, P. P., Savas, S., Woodrow, J., Wish, T., ... Parfrey, P. S. (2013). Dietary patterns and colorectal cancer recurrence and survival: a cohort study. BMJ Open, 3(2), doi:10.1136/bmjopen-2012-002270.
    Zhu Y, et al. Dietary Patterns and Colorectal Cancer Recurrence and Survival: a Cohort Study. BMJ Open. 2013;3(2) PubMed PMID: 23396503.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary patterns and colorectal cancer recurrence and survival: a cohort study. AU - Zhu,Yun, AU - Wu,Hao, AU - Wang,Peizhong Peter, AU - Savas,Sevtap, AU - Woodrow,Jennifer, AU - Wish,Tyler, AU - Jin,Rong, AU - Green,Roger, AU - Woods,Michael, AU - Roebothan,Barbara, AU - Buehler,Sharon, AU - Dicks,Elizabeth, AU - McLaughlin,John R, AU - Campbell,Peter T, AU - Parfrey,Patrick S, Y1 - 2013/02/07/ PY - 2013/2/12/entrez PY - 2013/2/12/pubmed PY - 2013/2/12/medline JF - BMJ open JO - BMJ Open VL - 3 IS - 2 N2 - OBJECTIVE: To examine the association between dietary patterns and colorectal cancer (CRC) survival. DESIGN: Cohort study. SETTING: A familial CRC registry in Newfoundland. PARTICIPANTS: 529 newly diagnosed CRC patients from Newfoundland. They were recruited from 1999 to 2003 and followed up until April 2010. OUTCOME MEASURE: Participants reported their dietary intake using a food frequency questionnaire. Dietary patterns were identified with factor analysis. Multivariable Cox proportional hazards models were employed to estimate HR and 95% CI for association of dietary patterns with CRC recurrence and death from all causes, after controlling for covariates. RESULTS: Disease-free survival (DFS) among CRC patients was significantly worsened among patients with a high processed meat dietary pattern (the highest vs the lowest quartile HR 1.82, 95% CI 1.07 to 3.09). No associations were observed with the prudent vegetable or the high-sugar patterns and DFS. The association between the processed meat pattern and DFS was restricted to patients diagnosed with colon cancer (the highest vs the lowest quartile: HR 2.29, 95% CI 1.19 to 4.40) whereas the relationship between overall survival (OS) and this pattern was observed among patients with colon cancer only (the highest vs the lowest quartile: HR 2.13, 95% CI 1.03 to 4.43). Potential effect modification was noted for sex (p value for interaction 0.04, HR 3.85 for women and 1.22 for men). CONCLUSIONS: The processed meat dietary pattern prior to diagnosis is associated with higher risk of tumour recurrence, metastasis and death among patients with CRC. SN - 2044-6055 UR - https://www.unboundmedicine.com/medline/citation/23396503/full_citation L2 - http://bmjopen.bmj.com/cgi/pmidlookup?view=long&pmid=23396503 DB - PRIME DP - Unbound Medicine ER -