TY - JOUR T1 - Extracellular vesicles: exosomes, microvesicles, and friends. AU - Raposo,Graça, AU - Stoorvogel,Willem, PY - 2013/2/20/entrez PY - 2013/2/20/pubmed PY - 2013/4/27/medline SP - 373 EP - 83 JF - The Journal of cell biology JO - J Cell Biol VL - 200 IS - 4 N2 - Cells release into the extracellular environment diverse types of membrane vesicles of endosomal and plasma membrane origin called exosomes and microvesicles, respectively. These extracellular vesicles (EVs) represent an important mode of intercellular communication by serving as vehicles for transfer between cells of membrane and cytosolic proteins, lipids, and RNA. Deficiencies in our knowledge of the molecular mechanisms for EV formation and lack of methods to interfere with the packaging of cargo or with vesicle release, however, still hamper identification of their physiological relevance in vivo. In this review, we focus on the characterization of EVs and on currently proposed mechanisms for their formation, targeting, and function. SN - 1540-8140 UR - https://www.unboundmedicine.com/medline/citation/23420871/Extracellular_vesicles:_exosomes__microvesicles__and_friends_ L2 - https://rupress.org/jcb/article-lookup/doi/10.1083/jcb.201211138 DB - PRIME DP - Unbound Medicine ER -