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Randomized, double-blind, placebo-controlled trial of vitamin D supplementation in Parkinson disease.
Am J Clin Nutr 2013; 97(5):1004-13AJ

Abstract

BACKGROUND

In our previous study, higher serum 25-hydroxyvitamin D [25(OH)D] concentrations and the vitamin D receptor (VDR) FokI CC genotype were associated with milder Parkinson disease (PD).

OBJECTIVE

We evaluated whether vitamin D3 supplementation inhibits the progression of PD on the basis of patient VDR subgroups.

DESIGN

Patients with PD (n = 114) were randomly assigned to receive vitamin D3 supplements (n = 56; 1200 IU/d) or a placebo (n = 58) for 12 mo in a double-blind setting. Outcomes were clinical changes from baseline and the percentage of patients who showed no worsening of the modified Hoehn and Yahr (HY) stage and Unified Parkinson's Disease Rating Scale (UPDRS).

RESULTS

Compared with the placebo, vitamin D3 significantly prevented the deterioration of the HY stage in patients [difference between groups: P = 0.005; mean ± SD change within vitamin D3 group: +0.02 ± 0.62 (P = 0.79); change within placebo group: +0.33 ± 0.70 (P = 0.0006)]. Interaction analyses showed that VDR FokI genotypes modified the effect of vitamin D3 on changes in the HY stage (P-interaction = 0.045), UPDRS total (P-interaction = 0.039), and UPDRS part II (P-interaction = 0.021). Compared with the placebo, vitamin D3 significantly prevented deterioration of the HY stage in patients with FokI TT [difference between groups: P = 0.009; change within vitamin D3 group: -0.38 ± 0.48 (P = 0.91); change within placebo group, +0.63 ± 0.77 (P = 0.009)] and FokI CT [difference between groups: P = 0.020; change within vitamin D3 group: ±0.00 ± 0.60 (P = 0.78); change within placebo group: +0.37 ± 0.74 (P = 0.014)] but not FokI CC. Similar trends were observed in UPDRS total and part II.

CONCLUSION

Vitamin D3 supplementation may stabilize PD for a short period in patients with FokI TT or CT genotypes without triggering hypercalcemia, although this effect may be nonspecific for PD. This trial was registered at UMIN Clinical Trials Registry as UMIN000001841.

Authors+Show Affiliations

Department of Neurology, Katsushika Medical Center and the Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23485413

Citation

Suzuki, Masahiko, et al. "Randomized, Double-blind, Placebo-controlled Trial of Vitamin D Supplementation in Parkinson Disease." The American Journal of Clinical Nutrition, vol. 97, no. 5, 2013, pp. 1004-13.
Suzuki M, Yoshioka M, Hashimoto M, et al. Randomized, double-blind, placebo-controlled trial of vitamin D supplementation in Parkinson disease. Am J Clin Nutr. 2013;97(5):1004-13.
Suzuki, M., Yoshioka, M., Hashimoto, M., Murakami, M., Noya, M., Takahashi, D., & Urashima, M. (2013). Randomized, double-blind, placebo-controlled trial of vitamin D supplementation in Parkinson disease. The American Journal of Clinical Nutrition, 97(5), pp. 1004-13. doi:10.3945/ajcn.112.051664.
Suzuki M, et al. Randomized, Double-blind, Placebo-controlled Trial of Vitamin D Supplementation in Parkinson Disease. Am J Clin Nutr. 2013;97(5):1004-13. PubMed PMID: 23485413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized, double-blind, placebo-controlled trial of vitamin D supplementation in Parkinson disease. AU - Suzuki,Masahiko, AU - Yoshioka,Masayuki, AU - Hashimoto,Masaya, AU - Murakami,Maiko, AU - Noya,Miki, AU - Takahashi,Daisuke, AU - Urashima,Mitsuyoshi, Y1 - 2013/03/13/ PY - 2013/3/15/entrez PY - 2013/3/15/pubmed PY - 2013/6/19/medline SP - 1004 EP - 13 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 97 IS - 5 N2 - BACKGROUND: In our previous study, higher serum 25-hydroxyvitamin D [25(OH)D] concentrations and the vitamin D receptor (VDR) FokI CC genotype were associated with milder Parkinson disease (PD). OBJECTIVE: We evaluated whether vitamin D3 supplementation inhibits the progression of PD on the basis of patient VDR subgroups. DESIGN: Patients with PD (n = 114) were randomly assigned to receive vitamin D3 supplements (n = 56; 1200 IU/d) or a placebo (n = 58) for 12 mo in a double-blind setting. Outcomes were clinical changes from baseline and the percentage of patients who showed no worsening of the modified Hoehn and Yahr (HY) stage and Unified Parkinson's Disease Rating Scale (UPDRS). RESULTS: Compared with the placebo, vitamin D3 significantly prevented the deterioration of the HY stage in patients [difference between groups: P = 0.005; mean ± SD change within vitamin D3 group: +0.02 ± 0.62 (P = 0.79); change within placebo group: +0.33 ± 0.70 (P = 0.0006)]. Interaction analyses showed that VDR FokI genotypes modified the effect of vitamin D3 on changes in the HY stage (P-interaction = 0.045), UPDRS total (P-interaction = 0.039), and UPDRS part II (P-interaction = 0.021). Compared with the placebo, vitamin D3 significantly prevented deterioration of the HY stage in patients with FokI TT [difference between groups: P = 0.009; change within vitamin D3 group: -0.38 ± 0.48 (P = 0.91); change within placebo group, +0.63 ± 0.77 (P = 0.009)] and FokI CT [difference between groups: P = 0.020; change within vitamin D3 group: ±0.00 ± 0.60 (P = 0.78); change within placebo group: +0.37 ± 0.74 (P = 0.014)] but not FokI CC. Similar trends were observed in UPDRS total and part II. CONCLUSION: Vitamin D3 supplementation may stabilize PD for a short period in patients with FokI TT or CT genotypes without triggering hypercalcemia, although this effect may be nonspecific for PD. This trial was registered at UMIN Clinical Trials Registry as UMIN000001841. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/23485413/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.051664 DB - PRIME DP - Unbound Medicine ER -