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Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence.

Abstract

BACKGROUND

Optimal vitamin D intake and its status are important not only for bone and calcium-phosphate metabolism, but also for overall health and well-being. Vitamin D deficiency and insufficiency as a global health problem are likely to be a risk for wide spectrum of acute and chronic illnesses.

METHODS

A review of randomized controlled trials, meta-analyses, and other evidence of vitamin D action on various health outcomes.

RESULTS

Adequate vitamin D status seems to be protective against musculoskeletal disorders (muscle weakness, falls, fractures), infectious diseases, autoimmune diseases, cardiovascular disease, type 1 and type 2 diabetes mellitus, several types of cancer, neurocognitive dysfunction and mental illness, and other diseases, as well as infertility and adverse pregnancy and birth outcomes. Vitamin D deficiency/insufficiency is associated with all-cause mortality.

CONCLUSIONS

Adequate vitamin D supplementation and sensible sunlight exposure to reach optimal vitamin D status are among the front line factors of prophylaxis for the spectrum of disorders. Supplementation guidance and population strategies for the eradication of vitamin D deficiency must be included in the priorities of physicians, medical professionals and healthcare policy-makers.

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  • Authors+Show Affiliations

    ,

    Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland. p.pludowski@czd.pl

    , , , , , , , , ,

    Source

    Autoimmunity reviews 12:10 2013 Aug pg 976-89

    MeSH

    Calcium
    Dietary Supplements
    Female
    Global Health
    Humans
    Pregnancy
    Vitamin D
    Vitamin D Deficiency
    Vitamins

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    23542507

    Citation

    Pludowski, Pawel, et al. "Vitamin D Effects On Musculoskeletal Health, Immunity, Autoimmunity, Cardiovascular Disease, Cancer, Fertility, Pregnancy, Dementia and Mortality-a Review of Recent Evidence." Autoimmunity Reviews, vol. 12, no. 10, 2013, pp. 976-89.
    Pludowski P, Holick MF, Pilz S, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev. 2013;12(10):976-89.
    Pludowski, P., Holick, M. F., Pilz, S., Wagner, C. L., Hollis, B. W., Grant, W. B., ... Soni, M. (2013). Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmunity Reviews, 12(10), pp. 976-89. doi:10.1016/j.autrev.2013.02.004.
    Pludowski P, et al. Vitamin D Effects On Musculoskeletal Health, Immunity, Autoimmunity, Cardiovascular Disease, Cancer, Fertility, Pregnancy, Dementia and Mortality-a Review of Recent Evidence. Autoimmun Rev. 2013;12(10):976-89. PubMed PMID: 23542507.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. AU - Pludowski,Pawel, AU - Holick,Michael F, AU - Pilz,Stefan, AU - Wagner,Carol L, AU - Hollis,Bruce W, AU - Grant,William B, AU - Shoenfeld,Yehuda, AU - Lerchbaum,Elisabeth, AU - Llewellyn,David J, AU - Kienreich,Katharina, AU - Soni,Maya, Y1 - 2013/03/28/ PY - 2013/02/12/received PY - 2013/02/28/accepted PY - 2013/4/2/entrez PY - 2013/4/2/pubmed PY - 2014/1/22/medline KW - 25(OH)D level KW - Autoimmunity KW - Cancer KW - Cardiovascular KW - Dementia KW - Falls KW - Fertility KW - Fractures KW - Immunity KW - Infancy KW - Infections KW - Mortality KW - Pregnancy KW - Vitamin D SP - 976 EP - 89 JF - Autoimmunity reviews JO - Autoimmun Rev VL - 12 IS - 10 N2 - BACKGROUND: Optimal vitamin D intake and its status are important not only for bone and calcium-phosphate metabolism, but also for overall health and well-being. Vitamin D deficiency and insufficiency as a global health problem are likely to be a risk for wide spectrum of acute and chronic illnesses. METHODS: A review of randomized controlled trials, meta-analyses, and other evidence of vitamin D action on various health outcomes. RESULTS: Adequate vitamin D status seems to be protective against musculoskeletal disorders (muscle weakness, falls, fractures), infectious diseases, autoimmune diseases, cardiovascular disease, type 1 and type 2 diabetes mellitus, several types of cancer, neurocognitive dysfunction and mental illness, and other diseases, as well as infertility and adverse pregnancy and birth outcomes. Vitamin D deficiency/insufficiency is associated with all-cause mortality. CONCLUSIONS: Adequate vitamin D supplementation and sensible sunlight exposure to reach optimal vitamin D status are among the front line factors of prophylaxis for the spectrum of disorders. Supplementation guidance and population strategies for the eradication of vitamin D deficiency must be included in the priorities of physicians, medical professionals and healthcare policy-makers. SN - 1873-0183 UR - https://www.unboundmedicine.com/medline/citation/23542507/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1568-9972(13)00040-2 DB - PRIME DP - Unbound Medicine ER -