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Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence.
Autoimmun Rev 2013; 12(10):976-89AR

Abstract

BACKGROUND

Optimal vitamin D intake and its status are important not only for bone and calcium-phosphate metabolism, but also for overall health and well-being. Vitamin D deficiency and insufficiency as a global health problem are likely to be a risk for wide spectrum of acute and chronic illnesses.

METHODS

A review of randomized controlled trials, meta-analyses, and other evidence of vitamin D action on various health outcomes.

RESULTS

Adequate vitamin D status seems to be protective against musculoskeletal disorders (muscle weakness, falls, fractures), infectious diseases, autoimmune diseases, cardiovascular disease, type 1 and type 2 diabetes mellitus, several types of cancer, neurocognitive dysfunction and mental illness, and other diseases, as well as infertility and adverse pregnancy and birth outcomes. Vitamin D deficiency/insufficiency is associated with all-cause mortality.

CONCLUSIONS

Adequate vitamin D supplementation and sensible sunlight exposure to reach optimal vitamin D status are among the front line factors of prophylaxis for the spectrum of disorders. Supplementation guidance and population strategies for the eradication of vitamin D deficiency must be included in the priorities of physicians, medical professionals and healthcare policy-makers.

Authors+Show Affiliations

Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland. p.pludowski@czd.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23542507

Citation

Pludowski, Pawel, et al. "Vitamin D Effects On Musculoskeletal Health, Immunity, Autoimmunity, Cardiovascular Disease, Cancer, Fertility, Pregnancy, Dementia and Mortality-a Review of Recent Evidence." Autoimmunity Reviews, vol. 12, no. 10, 2013, pp. 976-89.
Pludowski P, Holick MF, Pilz S, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev. 2013;12(10):976-89.
Pludowski, P., Holick, M. F., Pilz, S., Wagner, C. L., Hollis, B. W., Grant, W. B., ... Soni, M. (2013). Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmunity Reviews, 12(10), pp. 976-89. doi:10.1016/j.autrev.2013.02.004.
Pludowski P, et al. Vitamin D Effects On Musculoskeletal Health, Immunity, Autoimmunity, Cardiovascular Disease, Cancer, Fertility, Pregnancy, Dementia and Mortality-a Review of Recent Evidence. Autoimmun Rev. 2013;12(10):976-89. PubMed PMID: 23542507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. AU - Pludowski,Pawel, AU - Holick,Michael F, AU - Pilz,Stefan, AU - Wagner,Carol L, AU - Hollis,Bruce W, AU - Grant,William B, AU - Shoenfeld,Yehuda, AU - Lerchbaum,Elisabeth, AU - Llewellyn,David J, AU - Kienreich,Katharina, AU - Soni,Maya, Y1 - 2013/03/28/ PY - 2013/02/12/received PY - 2013/02/28/accepted PY - 2013/4/2/entrez PY - 2013/4/2/pubmed PY - 2014/1/22/medline KW - 25(OH)D level KW - Autoimmunity KW - Cancer KW - Cardiovascular KW - Dementia KW - Falls KW - Fertility KW - Fractures KW - Immunity KW - Infancy KW - Infections KW - Mortality KW - Pregnancy KW - Vitamin D SP - 976 EP - 89 JF - Autoimmunity reviews JO - Autoimmun Rev VL - 12 IS - 10 N2 - BACKGROUND: Optimal vitamin D intake and its status are important not only for bone and calcium-phosphate metabolism, but also for overall health and well-being. Vitamin D deficiency and insufficiency as a global health problem are likely to be a risk for wide spectrum of acute and chronic illnesses. METHODS: A review of randomized controlled trials, meta-analyses, and other evidence of vitamin D action on various health outcomes. RESULTS: Adequate vitamin D status seems to be protective against musculoskeletal disorders (muscle weakness, falls, fractures), infectious diseases, autoimmune diseases, cardiovascular disease, type 1 and type 2 diabetes mellitus, several types of cancer, neurocognitive dysfunction and mental illness, and other diseases, as well as infertility and adverse pregnancy and birth outcomes. Vitamin D deficiency/insufficiency is associated with all-cause mortality. CONCLUSIONS: Adequate vitamin D supplementation and sensible sunlight exposure to reach optimal vitamin D status are among the front line factors of prophylaxis for the spectrum of disorders. Supplementation guidance and population strategies for the eradication of vitamin D deficiency must be included in the priorities of physicians, medical professionals and healthcare policy-makers. SN - 1873-0183 UR - https://www.unboundmedicine.com/medline/citation/23542507/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1568-9972(13)00040-2 DB - PRIME DP - Unbound Medicine ER -