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Dietary habits are related to outcomes in patients with advanced heart failure awaiting heart transplantation.

Abstract

BACKGROUND

Empirical evidence supporting the benefits of dietary recommendations for patients with advanced heart failure is scarce. We prospectively evaluated the relation of dietary habits to pre-transplant clinical outcomes in the multisite observational Waiting for a New Heart Study.

METHODS AND RESULTS

A total of 318 heart transplant candidates (82% male, age 53 ± 11 years) completed a Food Frequency Questionnaire (foods high in salt, saturated fats, poly-/monounsaturated fats [PUFA+MUFA], fruit/vegetables/legumes, and fluid intake) at time of waitlisting. Cox proportional hazard models controlling for heart failure severity (eg, Heart Failure Survival Score, creatinine) estimated cause-specific hazard ratios (HRs) associated with each dietary habit individually, and with all dietary habits entered simultaneously. During follow-up (median 338 days, range 13-1,394), 54 patients died, 151 received transplants (110 in high-urgency status, 41 electively), and 45 became delisted (15 deteriorated, 30 improved). Two robust findings emerged: Frequent intake of salty foods, which correlated positively with saturated fat and fluid intake, was associated with transplantation in high-urgency status (HR 2.90, 95% confidence interval [CI] 1.55-5.42); and frequent intake of foods rich in PUFA+MUFA reduced the risk for death/deterioration (HR 0.49, 95% CI 0.26-0.92).

CONCLUSIONS

These results support the importance of dietary habits for the prognosis of patients listed for heart transplantation, independently from heart failure severity.

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  • Authors+Show Affiliations

    ,

    Department of Psychology, Johannes Gutenberg University, Mainz, Germany. spaderna@uni-wuppertal.de

    , , , , , , ,

    Source

    Journal of cardiac failure 19:4 2013 Apr pg 240-50

    MeSH

    Adult
    Dietary Fats
    Feeding Behavior
    Female
    Heart Failure
    Heart Transplantation
    Humans
    Male
    Middle Aged
    Prospective Studies
    Severity of Illness Index
    Sodium Chloride, Dietary
    Surveys and Questionnaires
    Treatment Outcome
    Waiting Lists

    Pub Type(s)

    Journal Article
    Multicenter Study

    Language

    eng

    PubMed ID

    23582090

    Citation

    Spaderna, Heike, et al. "Dietary Habits Are Related to Outcomes in Patients With Advanced Heart Failure Awaiting Heart Transplantation." Journal of Cardiac Failure, vol. 19, no. 4, 2013, pp. 240-50.
    Spaderna H, Zahn D, Pretsch J, et al. Dietary habits are related to outcomes in patients with advanced heart failure awaiting heart transplantation. J Card Fail. 2013;19(4):240-50.
    Spaderna, H., Zahn, D., Pretsch, J., Connor, S. L., Zittermann, A., Schulze Schleithoff, S., ... Weidner, G. (2013). Dietary habits are related to outcomes in patients with advanced heart failure awaiting heart transplantation. Journal of Cardiac Failure, 19(4), pp. 240-50. doi:10.1016/j.cardfail.2013.02.004.
    Spaderna H, et al. Dietary Habits Are Related to Outcomes in Patients With Advanced Heart Failure Awaiting Heart Transplantation. J Card Fail. 2013;19(4):240-50. PubMed PMID: 23582090.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary habits are related to outcomes in patients with advanced heart failure awaiting heart transplantation. AU - Spaderna,Heike, AU - Zahn,Daniela, AU - Pretsch,Johanna, AU - Connor,Sonja L, AU - Zittermann,Armin, AU - Schulze Schleithoff,Stefanie, AU - Bramstedt,Katrina A, AU - Smits,Jacqueline M A, AU - Weidner,Gerdi, PY - 2012/06/29/received PY - 2013/02/16/revised PY - 2013/02/27/accepted PY - 2013/4/16/entrez PY - 2013/4/16/pubmed PY - 2014/1/22/medline SP - 240 EP - 50 JF - Journal of cardiac failure JO - J. Card. Fail. VL - 19 IS - 4 N2 - BACKGROUND: Empirical evidence supporting the benefits of dietary recommendations for patients with advanced heart failure is scarce. We prospectively evaluated the relation of dietary habits to pre-transplant clinical outcomes in the multisite observational Waiting for a New Heart Study. METHODS AND RESULTS: A total of 318 heart transplant candidates (82% male, age 53 ± 11 years) completed a Food Frequency Questionnaire (foods high in salt, saturated fats, poly-/monounsaturated fats [PUFA+MUFA], fruit/vegetables/legumes, and fluid intake) at time of waitlisting. Cox proportional hazard models controlling for heart failure severity (eg, Heart Failure Survival Score, creatinine) estimated cause-specific hazard ratios (HRs) associated with each dietary habit individually, and with all dietary habits entered simultaneously. During follow-up (median 338 days, range 13-1,394), 54 patients died, 151 received transplants (110 in high-urgency status, 41 electively), and 45 became delisted (15 deteriorated, 30 improved). Two robust findings emerged: Frequent intake of salty foods, which correlated positively with saturated fat and fluid intake, was associated with transplantation in high-urgency status (HR 2.90, 95% confidence interval [CI] 1.55-5.42); and frequent intake of foods rich in PUFA+MUFA reduced the risk for death/deterioration (HR 0.49, 95% CI 0.26-0.92). CONCLUSIONS: These results support the importance of dietary habits for the prognosis of patients listed for heart transplantation, independently from heart failure severity. SN - 1532-8414 UR - https://www.unboundmedicine.com/medline/citation/23582090/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1071-9164(13)00067-5 DB - PRIME DP - Unbound Medicine ER -