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Effect of garlic on serum lipids: an updated meta-analysis.

Abstract

Hypercholesterolemia is associated with an increased risk of heart disease. The effect of garlic on blood lipids has been studied in numerous trials and summarized in meta-analyses, with conflicting results. This meta-analysis, the most comprehensive to date, includes 39 primary trials of the effect of garlic preparations on total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. The findings suggest garlic to be effective in reducing total serum cholesterol by 17 ± 6 mg/dL and low-density lipoprotein cholesterol by 9 ± 6 mg/dL in individuals with elevated total cholesterol levels (>200 mg/dL), provided garlic is used for longer than 2 months. An 8% reduction in total serum cholesterol is of clinical relevance and is associated with a 38% reduction in risk of coronary events at 50 years of age. High-density lipoprotein cholesterol levels improved only slightly, and triglycerides were not influenced significantly. Garlic preparations were highly tolerable in all trials and were associated with minimal side effects. They might be considered as an alternative option with a higher safety profile than conventional cholesterol-lowering medications in patients with slightly elevated cholesterol.

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  • Authors+Show Affiliations

    ,

    Discipline of General Practice, The University of Adelaide, Adelaide, South Australia, Australia. karinried@niim.com.au

    ,

    Source

    Nutrition reviews 71:5 2013 May pg 282-99

    MeSH

    Anticholesteremic Agents
    Cholesterol
    Garlic
    Humans
    Hypercholesterolemia
    Phytotherapy
    Plant Extracts
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    23590705

    Citation

    Ried, Karin, et al. "Effect of Garlic On Serum Lipids: an Updated Meta-analysis." Nutrition Reviews, vol. 71, no. 5, 2013, pp. 282-99.
    Ried K, Toben C, Fakler P. Effect of garlic on serum lipids: an updated meta-analysis. Nutr Rev. 2013;71(5):282-99.
    Ried, K., Toben, C., & Fakler, P. (2013). Effect of garlic on serum lipids: an updated meta-analysis. Nutrition Reviews, 71(5), pp. 282-99. doi:10.1111/nure.12012.
    Ried K, Toben C, Fakler P. Effect of Garlic On Serum Lipids: an Updated Meta-analysis. Nutr Rev. 2013;71(5):282-99. PubMed PMID: 23590705.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of garlic on serum lipids: an updated meta-analysis. AU - Ried,Karin, AU - Toben,Catherine, AU - Fakler,Peter, Y1 - 2013/03/07/ PY - 2013/4/18/entrez PY - 2013/4/18/pubmed PY - 2013/6/7/medline SP - 282 EP - 99 JF - Nutrition reviews JO - Nutr. Rev. VL - 71 IS - 5 N2 - Hypercholesterolemia is associated with an increased risk of heart disease. The effect of garlic on blood lipids has been studied in numerous trials and summarized in meta-analyses, with conflicting results. This meta-analysis, the most comprehensive to date, includes 39 primary trials of the effect of garlic preparations on total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. The findings suggest garlic to be effective in reducing total serum cholesterol by 17 ± 6 mg/dL and low-density lipoprotein cholesterol by 9 ± 6 mg/dL in individuals with elevated total cholesterol levels (>200 mg/dL), provided garlic is used for longer than 2 months. An 8% reduction in total serum cholesterol is of clinical relevance and is associated with a 38% reduction in risk of coronary events at 50 years of age. High-density lipoprotein cholesterol levels improved only slightly, and triglycerides were not influenced significantly. Garlic preparations were highly tolerable in all trials and were associated with minimal side effects. They might be considered as an alternative option with a higher safety profile than conventional cholesterol-lowering medications in patients with slightly elevated cholesterol. SN - 1753-4887 UR - https://www.unboundmedicine.com/medline/citation/23590705/full_citation L2 - https://academic.oup.com/nutritionreviews/article-lookup/doi/10.1111/nure.12012 DB - PRIME DP - Unbound Medicine ER -