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Undernutrition in patients with COPD and its treatment.

Abstract

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder of the lung and whole body caused mainly by tobacco smoking. Patients with advanced COPD are in a state of undernutrition, referred to as pulmonary cachexia; the exercise performance and quality of life (QOL) of these patients are deteriorated, the vital prognosis is unfavorable, and the medico-economic burden posed by poorly nourished COPD patients is high. The mainstays of COPD treatment are pharmacotherapy, mainly with bronchodilators, and non-pharmacotherapeutic approaches such as respiratory rehabilitation and nutrition counseling. Nutritional supplement therapy, consisting primarily of high calorie intake, has been demonstrated to be effective for maintaining and improving the muscle strength and exercise tolerance in poorly nourished COPD patients. The efficacy of intake of various nutrients, besides a high calorie intake, for amelioration of the disease state of COPD has also been reported. The roles of adipokines in the pathophysiology of COPD have begun to receive attention recently, and not only their regulatory effects on appetite and nutritional status, but also their influence on systemic inflammation have been increasingly clarified. We review the papers on COPD and nutrition and discuss the role of nutritional supplement therapy in the treatment of COPD.

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  • Authors+Show Affiliations

    ,

    Department of Respiratory Medicine, Tokyo Medical University Ibaraki Medical Center, 3-20-1 Chuou, Ami, Inashiki, Ibaraki, 300-0395, Japan.

    , , ,

    Source

    Nutrients 5:4 2013 Apr 18 pg 1316-35

    MeSH

    Adipokines
    Animals
    Cachexia
    Dietary Supplements
    Energy Intake
    Fruit
    Humans
    Malnutrition
    Nutritional Status
    Nutritional Support
    Pulmonary Disease, Chronic Obstructive
    Treatment Outcome
    Vegetables

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    23598440

    Citation

    Itoh, Masayuki, et al. "Undernutrition in Patients With COPD and Its Treatment." Nutrients, vol. 5, no. 4, 2013, pp. 1316-35.
    Itoh M, Tsuji T, Nemoto K, et al. Undernutrition in patients with COPD and its treatment. Nutrients. 2013;5(4):1316-35.
    Itoh, M., Tsuji, T., Nemoto, K., Nakamura, H., & Aoshiba, K. (2013). Undernutrition in patients with COPD and its treatment. Nutrients, 5(4), pp. 1316-35. doi:10.3390/nu5041316.
    Itoh M, et al. Undernutrition in Patients With COPD and Its Treatment. Nutrients. 2013 Apr 18;5(4):1316-35. PubMed PMID: 23598440.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Undernutrition in patients with COPD and its treatment. AU - Itoh,Masayuki, AU - Tsuji,Takao, AU - Nemoto,Kenji, AU - Nakamura,Hiroyuki, AU - Aoshiba,Kazutetsu, Y1 - 2013/04/18/ PY - 2013/01/31/received PY - 2013/03/25/revised PY - 2013/04/08/accepted PY - 2013/4/20/entrez PY - 2013/4/20/pubmed PY - 2013/7/17/medline SP - 1316 EP - 35 JF - Nutrients JO - Nutrients VL - 5 IS - 4 N2 - Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder of the lung and whole body caused mainly by tobacco smoking. Patients with advanced COPD are in a state of undernutrition, referred to as pulmonary cachexia; the exercise performance and quality of life (QOL) of these patients are deteriorated, the vital prognosis is unfavorable, and the medico-economic burden posed by poorly nourished COPD patients is high. The mainstays of COPD treatment are pharmacotherapy, mainly with bronchodilators, and non-pharmacotherapeutic approaches such as respiratory rehabilitation and nutrition counseling. Nutritional supplement therapy, consisting primarily of high calorie intake, has been demonstrated to be effective for maintaining and improving the muscle strength and exercise tolerance in poorly nourished COPD patients. The efficacy of intake of various nutrients, besides a high calorie intake, for amelioration of the disease state of COPD has also been reported. The roles of adipokines in the pathophysiology of COPD have begun to receive attention recently, and not only their regulatory effects on appetite and nutritional status, but also their influence on systemic inflammation have been increasingly clarified. We review the papers on COPD and nutrition and discuss the role of nutritional supplement therapy in the treatment of COPD. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/23598440/full_citation L2 - http://www.mdpi.com/resolver?pii=nu5041316 DB - PRIME DP - Unbound Medicine ER -