Citation
Fuertes, Elaine, et al. "Childhood Allergic Rhinitis, Traffic-related Air Pollution, and Variability in the GSTP1, TNF, TLR2, and TLR4 Genes: Results From the TAG Study." The Journal of Allergy and Clinical Immunology, vol. 132, no. 2, 2013, pp. 342-52.e2.
Fuertes E, Brauer M, MacIntyre E, et al. Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study. J Allergy Clin Immunol. 2013;132(2):342-52.e2.
Fuertes, E., Brauer, M., MacIntyre, E., Bauer, M., Bellander, T., von Berg, A., Berdel, D., Brunekreef, B., Chan-Yeung, M., Gehring, U., Herbarth, O., Hoffmann, B., Kerkhof, M., Klümper, C., Koletzko, S., Kozyrskyj, A., Kull, I., Heinrich, J., Melén, E., ... Carlsten, C. (2013). Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study. The Journal of Allergy and Clinical Immunology, 132(2), 342-e2. https://doi.org/10.1016/j.jaci.2013.03.007
Fuertes E, et al. Childhood Allergic Rhinitis, Traffic-related Air Pollution, and Variability in the GSTP1, TNF, TLR2, and TLR4 Genes: Results From the TAG Study. J Allergy Clin Immunol. 2013;132(2):342-52.e2. PubMed PMID: 23639307.
TY - JOUR
T1 - Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study.
AU - Fuertes,Elaine,
AU - Brauer,Michael,
AU - MacIntyre,Elaina,
AU - Bauer,Mario,
AU - Bellander,Tom,
AU - von Berg,Andrea,
AU - Berdel,Dietrich,
AU - Brunekreef,Bert,
AU - Chan-Yeung,Moira,
AU - Gehring,Ulrike,
AU - Herbarth,Olf,
AU - Hoffmann,Barbara,
AU - Kerkhof,Marjan,
AU - Klümper,Claudia,
AU - Koletzko,Sibylle,
AU - Kozyrskyj,Anita,
AU - Kull,Inger,
AU - Heinrich,Joachim,
AU - Melén,Erik,
AU - Pershagen,Göran,
AU - Postma,Dirkje,
AU - Tiesler,Carla M T,
AU - Carlsten,Chris,
AU - ,,
Y1 - 2013/04/30/
PY - 2012/08/30/received
PY - 2013/02/05/revised
PY - 2013/03/06/accepted
PY - 2013/5/4/entrez
PY - 2013/5/4/pubmed
PY - 2013/10/19/medline
KW - APMoSPHERE
KW - Air Pollution Modelling for Support to Policy on Health and Environmental Risk in Europe
KW - BAMSE
KW - CAPPS
KW - Canadian Asthma Primary Prevention Study
KW - Childhood allergic rhinitis
KW - Children, Allergy, Milieu, Stockholm, Epidemiological Survey
KW - GINIplus
KW - GSTP1
KW - German Infant study on the influence of Nutritional Intervention plus environmental and genetic influences on allergy development
KW - Glutathione-S-transferase pi 1
KW - LISAplus
KW - LUR
KW - Land-use regression
KW - Lifestyle related factors, Immune System and the development of Allergies in Childhood plus the influence of traffic emissions and genetics study
KW - NO(2)
KW - Nitrogen dioxide
KW - OR
KW - Odds ratio
KW - PIAMA
KW - PM
KW - Particulate matter
KW - Prevention and Incidence of Asthma and Mite Allergy
KW - SAGE
KW - SNP
KW - Single nucleotide polymorphism
KW - Study of Asthma, Genes, and Environment
KW - TAG
KW - TLR
KW - TLR4
KW - TNF
KW - TRAP
KW - Toll-like receptor
KW - Traffic, Asthma, and Genetics
KW - Traffic-related air pollution
KW - air pollution
KW - genetics
KW - interaction
SP - 342
EP - 52.e2
JF - The Journal of allergy and clinical immunology
JO - J Allergy Clin Immunol
VL - 132
IS - 2
N2 - BACKGROUND: Associations between traffic-related air pollution (TRAP) and allergic rhinitis remain inconsistent, possibly because of unexplored gene-environment interactions. OBJECTIVE: In a pooled analysis of 6 birth cohorts (Ntotal = 15,299), we examined whether TRAP and genetic polymorphisms related to inflammation and oxidative stress predict allergic rhinitis and sensitization. METHODS: Allergic rhinitis was defined with a doctor diagnosis or reported symptoms at age 7 or 8 years. Associations between nitrogen dioxide, particulate matter 2.5 (PM2.5) mass, PM2.5 absorbance, and ozone, estimated for each child at the year of birth, and single nucleotide polymorphisms within the GSTP1, TNF, TLR2, or TLR4 genes with allergic rhinitis and aeroallergen sensitization were examined with logistic regression. Models were stratified by genotype and interaction terms tested for gene-environment associations. RESULTS: Point estimates for associations between nitrogen dioxide, PM2.5 mass, and PM2.5 absorbance with allergic rhinitis were elevated, but only that for PM2.5 mass was statistically significant (1.37 [1.01, 1.86] per 5 μg/m(3)). This result was not robust to single-cohort exclusions. Carriers of at least 1 minor rs1800629 (TNF) or rs1927911 (TLR4) allele were consistently at an increased risk of developing allergic rhinitis (1.19 [1.00, 1.41] and 1.24 [1.01, 1.53], respectively), regardless of TRAP exposure. No evidence of gene-environment interactions was observed. CONCLUSION: The generally null effect of TRAP on allergic rhinitis and aeroallergen sensitization was not modified by the studied variants in the GSTP1, TNF, TLR2, or TLR4 genes. Children carrying a minor rs1800629 (TNF) or rs1927911 (TLR4) allele may be at a higher risk of allergic rhinitis.
SN - 1097-6825
UR - https://www.unboundmedicine.com/medline/citation/23639307/full_citation
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(13)00427-2
DB - PRIME
DP - Unbound Medicine
ER -