TY - JOUR T1 - The pathogenesis of Epstein-Barr virus persistent infection. AU - Thorley-Lawson,David A, AU - Hawkins,Jared B, AU - Tracy,Sean I, AU - Shapiro,Michael, Y1 - 2013/05/15/ PY - 2013/01/23/received PY - 2013/03/27/revised PY - 2013/04/15/accepted PY - 2013/5/21/entrez PY - 2013/5/21/pubmed PY - 2014/1/28/medline SP - 227 EP - 32 JF - Current opinion in virology JO - Curr Opin Virol VL - 3 IS - 3 N2 - Epstein-Barr virus (EBV) maintains a lifelong infection. According to the germinal center model (GCM), latently infected B cells transit the germinal center (GC) to become resting memory cells. Here, the virus resides quiescently, occasionally reactivating to infect new B cells, completing the cycle of infection. The GCM remains the only model that explains EBV biology and the pathogenesis of lymphoma. Recent work suggests modifications to the model notably that the virus contributes only modestly to the GC process and predictions from mathematical models that quiescence within memory B cells shapes the overall structure of viral infection but is not essential for persistence. Rather, it is the cycle of infection which allows viral persistence at the very low levels observed. SN - 1879-6265 UR - https://www.unboundmedicine.com/medline/citation/23683686/The_pathogenesis_of_Epstein_Barr_virus_persistent_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1879-6257(13)00057-6 DB - PRIME DP - Unbound Medicine ER -