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Post-diagnosis soy food intake and breast cancer survival: a meta-analysis of cohort studies.

Abstract

BACKGROUND AND OBJECTIVES

Data on associations between soy food intake after cancer diagnosis with breast cancer survival are conflicting, so we conducted this meta-analysis for more accurate evaluation.

METHODS

Comprehensive searches were conducted to find cohort studies of the relationship between soy food intake after cancer diagnosis and breast cancer survival. Data were analyzed with comprehensive meta-analysis software.

RESULTS

Five cohort studies (11,206 patients) were included. Pooling all comparisons, soy food intake after diagnosis was associated with reduced mortality (HR 0.85, 95%CI 0.77 0.93) and recurrence (HR 0.79, 95%CI 0.72 0.87). Pooling the comparisons of highest vs. lowest dose, soy food intake after diagnosis was again associated with reduced mortality (HR 0.84, 95%CI 0.71 0.99) and recurrence (HR 0.74, 95%CI 0.64 0.85). Subgroup analysis of ER status showed that soy food intake was associated with reduced mortality in both ER negative (highest vs. lowest: HR 0.75, 95%CI 0.64 0.88) and ER positive patients (highest vs. lowest: HR 0.72, 95%CI 0.61 0.84), and both premenopausal (highest vs. lowest: HR 0.78, 95%CI 0.69 0.88) and postmenopausal patients (highest vs. lowest: HR 0.81, 95%CI 0.73 0.91). In additioin, soy food intake was associated with reduced recurrence in ER negative (highest vs. lowest: HR 0.64, 95%CI 0.44 0.94) and ER+/PR+ (highest vs. lowest: HR 0.65, 95%CI 0.49 0.86), and postmenopausal patients (highest vs. lowest: HR 0.67, 95%CI 0.56 0.80).

CONCLUSION

Our meta- analysis showed that soy food intake might be associated with better survival, especially for ER negative, ER+/ PR+, and postmenopausal patients.

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  • Authors+Show Affiliations

    ,

    Department of Medical Oncology, Shengjing Hospital of China Medical University, Shenyang, China. chifeng71099@163.com

    , , , ,

    Source

    MeSH

    Breast Neoplasms
    Cohort Studies
    Female
    Humans
    Prognosis
    Soy Foods
    Survival Rate

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    23725149

    Citation

    Chi, Feng, et al. "Post-diagnosis Soy Food Intake and Breast Cancer Survival: a Meta-analysis of Cohort Studies." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 14, no. 4, 2013, pp. 2407-12.
    Chi F, Wu R, Zeng YC, et al. Post-diagnosis soy food intake and breast cancer survival: a meta-analysis of cohort studies. Asian Pac J Cancer Prev. 2013;14(4):2407-12.
    Chi, F., Wu, R., Zeng, Y. C., Xing, R., Liu, Y., & Xu, Z. G. (2013). Post-diagnosis soy food intake and breast cancer survival: a meta-analysis of cohort studies. Asian Pacific Journal of Cancer Prevention : APJCP, 14(4), pp. 2407-12.
    Chi F, et al. Post-diagnosis Soy Food Intake and Breast Cancer Survival: a Meta-analysis of Cohort Studies. Asian Pac J Cancer Prev. 2013;14(4):2407-12. PubMed PMID: 23725149.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Post-diagnosis soy food intake and breast cancer survival: a meta-analysis of cohort studies. AU - Chi,Feng, AU - Wu,Rong, AU - Zeng,Yue-Can, AU - Xing,Rui, AU - Liu,Yang, AU - Xu,Zhao-Guo, PY - 2013/6/4/entrez PY - 2013/6/4/pubmed PY - 2013/10/23/medline SP - 2407 EP - 12 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 14 IS - 4 N2 - BACKGROUND AND OBJECTIVES: Data on associations between soy food intake after cancer diagnosis with breast cancer survival are conflicting, so we conducted this meta-analysis for more accurate evaluation. METHODS: Comprehensive searches were conducted to find cohort studies of the relationship between soy food intake after cancer diagnosis and breast cancer survival. Data were analyzed with comprehensive meta-analysis software. RESULTS: Five cohort studies (11,206 patients) were included. Pooling all comparisons, soy food intake after diagnosis was associated with reduced mortality (HR 0.85, 95%CI 0.77 0.93) and recurrence (HR 0.79, 95%CI 0.72 0.87). Pooling the comparisons of highest vs. lowest dose, soy food intake after diagnosis was again associated with reduced mortality (HR 0.84, 95%CI 0.71 0.99) and recurrence (HR 0.74, 95%CI 0.64 0.85). Subgroup analysis of ER status showed that soy food intake was associated with reduced mortality in both ER negative (highest vs. lowest: HR 0.75, 95%CI 0.64 0.88) and ER positive patients (highest vs. lowest: HR 0.72, 95%CI 0.61 0.84), and both premenopausal (highest vs. lowest: HR 0.78, 95%CI 0.69 0.88) and postmenopausal patients (highest vs. lowest: HR 0.81, 95%CI 0.73 0.91). In additioin, soy food intake was associated with reduced recurrence in ER negative (highest vs. lowest: HR 0.64, 95%CI 0.44 0.94) and ER+/PR+ (highest vs. lowest: HR 0.65, 95%CI 0.49 0.86), and postmenopausal patients (highest vs. lowest: HR 0.67, 95%CI 0.56 0.80). CONCLUSION: Our meta- analysis showed that soy food intake might be associated with better survival, especially for ER negative, ER+/ PR+, and postmenopausal patients. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/23725149/full_citation L2 - http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:23725149&key=2013.14.4.2407 DB - PRIME DP - Unbound Medicine ER -