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Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial.
J Res Med Sci 2013; 18(2):123-6JR

Abstract

BACKGROUND

Taste abnormalities are common among cancer patients after starting radiotherapy or chemotherapy. Considering the role of zinc and reports on its beneficial effects in taste perception, we evaluated the preventive effects of zinc sulfate on radiation-induced taste alterations.

MATERIALS AND METHODS

In a randomized, placebo-controlled trial, adult patients with head and neck cancers who were on schedule for radiotherapy, with or without chemotherapy, were allocated to receive zinc sulfate (50 mg, three times a day) or placebo; started with beginning of radiotherapy and continued for one month later. Taste acuity was determined by measuring detection and recognition thresholds for four taste qualities at baseline, at the end of radiotherapy, and a month later using the Henkin method.

RESULTS

Thirty-five patients (mean age = 59.2 ± 16.5, 60% male) completed the trial. The two groups were similar at baseline. After radiotherapy, and one month later, there was a significant increase in taste perception threshold for bitter, salty, sweet, and sour tastes in the placebo group (P = 0.001). In those who received zinc, there was only slight increase in threshold for perception of the salty taste (P = 0.046). No relevant side effects due to zinc sulfate were reported.

CONCLUSION

Zinc supplementation in head/neck cancer patients under radiotherapy can prevent radiation-induced taste alterations. Further studies with longer follow-ups and with different doses of zinc supplementation are warranted in this regard.

Authors+Show Affiliations

Department of Radiation Oncology, School of Pharmacy, Isfahan University of Medical Science, Isfahan, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23914214

Citation

Najafizade, Nadia, et al. "Preventive Effects of Zinc Sulfate On Taste Alterations in Patients Under Irradiation for Head and Neck Cancers: a Randomized Placebo-controlled Trial." Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences, vol. 18, no. 2, 2013, pp. 123-6.
Najafizade N, Hemati S, Gookizade A, et al. Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial. J Res Med Sci. 2013;18(2):123-6.
Najafizade, N., Hemati, S., Gookizade, A., Berjis, N., Hashemi, M., Vejdani, S., ... Arbab, N. (2013). Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial. Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences, 18(2), pp. 123-6.
Najafizade N, et al. Preventive Effects of Zinc Sulfate On Taste Alterations in Patients Under Irradiation for Head and Neck Cancers: a Randomized Placebo-controlled Trial. J Res Med Sci. 2013;18(2):123-6. PubMed PMID: 23914214.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial. AU - Najafizade,Nadia, AU - Hemati,Simin, AU - Gookizade,Abbas, AU - Berjis,Nezameddin, AU - Hashemi,Mostafa, AU - Vejdani,Soheil, AU - Ghannadi,Alireza, AU - Shahsanaee,Armindokht, AU - Arbab,Nafise, PY - 2012/02/08/received PY - 2012/08/14/revised PY - 2012/10/23/accepted PY - 2013/8/6/entrez PY - 2013/8/6/pubmed PY - 2013/8/6/medline KW - Cancer KW - dysgeusia KW - radiotherapy KW - taste loss KW - taste perception KW - zinc sulfate SP - 123 EP - 6 JF - Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences JO - J Res Med Sci VL - 18 IS - 2 N2 - BACKGROUND: Taste abnormalities are common among cancer patients after starting radiotherapy or chemotherapy. Considering the role of zinc and reports on its beneficial effects in taste perception, we evaluated the preventive effects of zinc sulfate on radiation-induced taste alterations. MATERIALS AND METHODS: In a randomized, placebo-controlled trial, adult patients with head and neck cancers who were on schedule for radiotherapy, with or without chemotherapy, were allocated to receive zinc sulfate (50 mg, three times a day) or placebo; started with beginning of radiotherapy and continued for one month later. Taste acuity was determined by measuring detection and recognition thresholds for four taste qualities at baseline, at the end of radiotherapy, and a month later using the Henkin method. RESULTS: Thirty-five patients (mean age = 59.2 ± 16.5, 60% male) completed the trial. The two groups were similar at baseline. After radiotherapy, and one month later, there was a significant increase in taste perception threshold for bitter, salty, sweet, and sour tastes in the placebo group (P = 0.001). In those who received zinc, there was only slight increase in threshold for perception of the salty taste (P = 0.046). No relevant side effects due to zinc sulfate were reported. CONCLUSION: Zinc supplementation in head/neck cancer patients under radiotherapy can prevent radiation-induced taste alterations. Further studies with longer follow-ups and with different doses of zinc supplementation are warranted in this regard. SN - 1735-1995 UR - https://www.unboundmedicine.com/medline/citation/23914214/full_citation L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23914214/ DB - PRIME DP - Unbound Medicine ER -