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General health issues in multiple sclerosis: comorbidities, secondary conditions, and health behaviors.

Abstract

PURPOSE OF REVIEW

Comorbid conditions, secondary conditions, and health behaviors are increasingly recognized to be important factors influencing a range of outcomes in multiple sclerosis (MS). This review discusses the most common comorbidities experienced in MS, their impact on clinical outcomes, and the impact of health behaviors. Osteoporosis is a common secondary condition in MS that will be discussed along with vitamin D insufficiency.

RECENT FINDINGS

Mental comorbidity is common in MS; depression has a lifetime prevalence of 50%, while anxiety has a lifetime prevalence of 36%. Physical comorbidity is also common, with the most frequently reported conditions including hyperlipidemia, hypertension, arthritis, irritable bowel syndrome, and chronic lung disease. Fracture risk is increased among patients with MS because of an increased risk of osteoporosis and propensity for falls. Vitamin D insufficiency is common and may contribute to increased fracture risk and increased disease activity. Comorbidities and smoking are associated with diagnostic delays, increased disability progression, lower health-related quality of life, and lower adherence to treatment.

SUMMARY

Physical and mental comorbidity and adverse health behaviors are common in patients with MS. Comorbidities and health behaviors are associated with adverse outcomes in MS and should be considered in the assessment and management of patients with MS.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Health Sciences Center, GF-533, 820 Sherbrook Street, Winnipeg, MB, Canada. rmarrie@hsc.mb.ca

    Source

    Continuum (Minneapolis, Minn.) 19:4 Multiple Sclerosis 2013 Aug pg 1046-57

    MeSH

    Adult
    Bone Density Conservation Agents
    Female
    Health Behavior
    Humans
    Mental Disorders
    Middle Aged
    Multiple Sclerosis
    Osteoporosis
    Osteoporotic Fractures
    Overweight
    Risk Factors
    Risk-Taking
    Sedentary Behavior
    Sleep Wake Disorders
    Vitamin D

    Pub Type(s)

    Case Reports
    Journal Article
    Review

    Language

    eng

    PubMed ID

    23917100

    Citation

    Marrie, Ruth Ann, and Heather Hanwell. "General Health Issues in Multiple Sclerosis: Comorbidities, Secondary Conditions, and Health Behaviors." Continuum (Minneapolis, Minn.), vol. 19, no. 4 Multiple Sclerosis, 2013, pp. 1046-57.
    Marrie RA, Hanwell H. General health issues in multiple sclerosis: comorbidities, secondary conditions, and health behaviors. Continuum (Minneap Minn). 2013;19(4 Multiple Sclerosis):1046-57.
    Marrie, R. A., & Hanwell, H. (2013). General health issues in multiple sclerosis: comorbidities, secondary conditions, and health behaviors. Continuum (Minneapolis, Minn.), 19(4 Multiple Sclerosis), pp. 1046-57. doi:10.1212/01.CON.0000433284.07844.6b.
    Marrie RA, Hanwell H. General Health Issues in Multiple Sclerosis: Comorbidities, Secondary Conditions, and Health Behaviors. Continuum (Minneap Minn). 2013;19(4 Multiple Sclerosis):1046-57. PubMed PMID: 23917100.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - General health issues in multiple sclerosis: comorbidities, secondary conditions, and health behaviors. AU - Marrie,Ruth Ann, AU - Hanwell,Heather, PY - 2013/8/7/entrez PY - 2013/8/7/pubmed PY - 2014/3/13/medline SP - 1046 EP - 57 JF - Continuum (Minneapolis, Minn.) JO - Continuum (Minneap Minn) VL - 19 IS - 4 Multiple Sclerosis N2 - PURPOSE OF REVIEW: Comorbid conditions, secondary conditions, and health behaviors are increasingly recognized to be important factors influencing a range of outcomes in multiple sclerosis (MS). This review discusses the most common comorbidities experienced in MS, their impact on clinical outcomes, and the impact of health behaviors. Osteoporosis is a common secondary condition in MS that will be discussed along with vitamin D insufficiency. RECENT FINDINGS: Mental comorbidity is common in MS; depression has a lifetime prevalence of 50%, while anxiety has a lifetime prevalence of 36%. Physical comorbidity is also common, with the most frequently reported conditions including hyperlipidemia, hypertension, arthritis, irritable bowel syndrome, and chronic lung disease. Fracture risk is increased among patients with MS because of an increased risk of osteoporosis and propensity for falls. Vitamin D insufficiency is common and may contribute to increased fracture risk and increased disease activity. Comorbidities and smoking are associated with diagnostic delays, increased disability progression, lower health-related quality of life, and lower adherence to treatment. SUMMARY: Physical and mental comorbidity and adverse health behaviors are common in patients with MS. Comorbidities and health behaviors are associated with adverse outcomes in MS and should be considered in the assessment and management of patients with MS. SN - 1538-6899 UR - https://www.unboundmedicine.com/medline/citation/23917100/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=23917100 DB - PRIME DP - Unbound Medicine ER -