Tags

Type your tag names separated by a space and hit enter

Acne: risk indicator for increased body mass index and insulin resistance.

Abstract

Acne appears to represent a visible indicator disease of over-activated mTORC1 signalling, an unfavour-able metabolic deviation on the road to serious common Western diseases of civilisation associated with increased body mass index and insulin resistance. Exaggerated mTORC1 signalling by Western diet explains the association of acne with increased body mass index, insulin resistance, and early onset of menarche. Both, a high glycaemic load and increased consumption of milk and milk products, staples of Western diet, aggravate mammalian target of rapamycin complex 1 signalling. This review of the literature summarises present evidence for an association between acne, increased body mass index, insulin resistance and Western diet. By dietary intervention with a Palaeolithic-type diet, the dermatologist has the chance to attenuate patients' increased mTORC1 signalling by reducing glycaemic load and milk consumption, which may not only improve acne but may delay the march to more serious mTORC1-driven diseases of civilisation.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, DE-49076 Osnabrück, Germany. Melnik@t-online.de.

    ,

    Source

    Acta dermato-venereologica 93:6 2013 Nov pg 644-9

    MeSH

    Acne Vulgaris
    Age Factors
    Animals
    Body Mass Index
    Dietary Carbohydrates
    Female
    Glycemic Index
    Humans
    Insulin Resistance
    Male
    Mechanistic Target of Rapamycin Complex 1
    Milk
    Multiprotein Complexes
    Obesity
    Risk Factors
    Signal Transduction
    TOR Serine-Threonine Kinases
    Up-Regulation

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    23975508

    Citation

    Melnik, Bodo C., et al. "Acne: Risk Indicator for Increased Body Mass Index and Insulin Resistance." Acta Dermato-venereologica, vol. 93, no. 6, 2013, pp. 644-9.
    Melnik BC, John SM, Plewig G. Acne: risk indicator for increased body mass index and insulin resistance. Acta Derm Venereol. 2013;93(6):644-9.
    Melnik, B. C., John, S. M., & Plewig, G. (2013). Acne: risk indicator for increased body mass index and insulin resistance. Acta Dermato-venereologica, 93(6), pp. 644-9. doi:10.2340/00015555-1677.
    Melnik BC, John SM, Plewig G. Acne: Risk Indicator for Increased Body Mass Index and Insulin Resistance. Acta Derm Venereol. 2013;93(6):644-9. PubMed PMID: 23975508.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Acne: risk indicator for increased body mass index and insulin resistance. AU - Melnik,Bodo C, AU - John,Swen Malte, AU - Plewig,Gerd, PY - 2013/8/27/entrez PY - 2013/8/27/pubmed PY - 2014/6/19/medline SP - 644 EP - 9 JF - Acta dermato-venereologica JO - Acta Derm. Venereol. VL - 93 IS - 6 N2 - Acne appears to represent a visible indicator disease of over-activated mTORC1 signalling, an unfavour-able metabolic deviation on the road to serious common Western diseases of civilisation associated with increased body mass index and insulin resistance. Exaggerated mTORC1 signalling by Western diet explains the association of acne with increased body mass index, insulin resistance, and early onset of menarche. Both, a high glycaemic load and increased consumption of milk and milk products, staples of Western diet, aggravate mammalian target of rapamycin complex 1 signalling. This review of the literature summarises present evidence for an association between acne, increased body mass index, insulin resistance and Western diet. By dietary intervention with a Palaeolithic-type diet, the dermatologist has the chance to attenuate patients' increased mTORC1 signalling by reducing glycaemic load and milk consumption, which may not only improve acne but may delay the march to more serious mTORC1-driven diseases of civilisation. SN - 1651-2057 UR - https://www.unboundmedicine.com/medline/citation/23975508/full_citation L2 - https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-1677 DB - PRIME DP - Unbound Medicine ER -