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Acne: risk indicator for increased body mass index and insulin resistance.
Acta Derm Venereol 2013; 93(6):644-9AD

Abstract

Acne appears to represent a visible indicator disease of over-activated mTORC1 signalling, an unfavour-able metabolic deviation on the road to serious common Western diseases of civilisation associated with increased body mass index and insulin resistance. Exaggerated mTORC1 signalling by Western diet explains the association of acne with increased body mass index, insulin resistance, and early onset of menarche. Both, a high glycaemic load and increased consumption of milk and milk products, staples of Western diet, aggravate mammalian target of rapamycin complex 1 signalling. This review of the literature summarises present evidence for an association between acne, increased body mass index, insulin resistance and Western diet. By dietary intervention with a Palaeolithic-type diet, the dermatologist has the chance to attenuate patients' increased mTORC1 signalling by reducing glycaemic load and milk consumption, which may not only improve acne but may delay the march to more serious mTORC1-driven diseases of civilisation.

Authors+Show Affiliations

Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, DE-49076 Osnabrück, Germany. Melnik@t-online.de.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23975508

Citation

Melnik, Bodo C., et al. "Acne: Risk Indicator for Increased Body Mass Index and Insulin Resistance." Acta Dermato-venereologica, vol. 93, no. 6, 2013, pp. 644-9.
Melnik BC, John SM, Plewig G. Acne: risk indicator for increased body mass index and insulin resistance. Acta Derm Venereol. 2013;93(6):644-9.
Melnik, B. C., John, S. M., & Plewig, G. (2013). Acne: risk indicator for increased body mass index and insulin resistance. Acta Dermato-venereologica, 93(6), pp. 644-9. doi:10.2340/00015555-1677.
Melnik BC, John SM, Plewig G. Acne: Risk Indicator for Increased Body Mass Index and Insulin Resistance. Acta Derm Venereol. 2013;93(6):644-9. PubMed PMID: 23975508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acne: risk indicator for increased body mass index and insulin resistance. AU - Melnik,Bodo C, AU - John,Swen Malte, AU - Plewig,Gerd, PY - 2013/8/27/entrez PY - 2013/8/27/pubmed PY - 2014/6/19/medline SP - 644 EP - 9 JF - Acta dermato-venereologica JO - Acta Derm. Venereol. VL - 93 IS - 6 N2 - Acne appears to represent a visible indicator disease of over-activated mTORC1 signalling, an unfavour-able metabolic deviation on the road to serious common Western diseases of civilisation associated with increased body mass index and insulin resistance. Exaggerated mTORC1 signalling by Western diet explains the association of acne with increased body mass index, insulin resistance, and early onset of menarche. Both, a high glycaemic load and increased consumption of milk and milk products, staples of Western diet, aggravate mammalian target of rapamycin complex 1 signalling. This review of the literature summarises present evidence for an association between acne, increased body mass index, insulin resistance and Western diet. By dietary intervention with a Palaeolithic-type diet, the dermatologist has the chance to attenuate patients' increased mTORC1 signalling by reducing glycaemic load and milk consumption, which may not only improve acne but may delay the march to more serious mTORC1-driven diseases of civilisation. SN - 1651-2057 UR - https://www.unboundmedicine.com/medline/citation/23975508/full_citation L2 - https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-1677 DB - PRIME DP - Unbound Medicine ER -