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Allium vegetables and risk of prostate cancer: evidence from 132,192 subjects.

Abstract

OBJECTIVE

To evaluate the relationship between allium vegetable intake and risk of prostate cancer.

METHODS

A systematic literature search up to May 2013 was carried out in PubMed, EMBASE, Scopus, Web of Science, Cochrane register, and Chinese National Knowledge Infrastructure (CNKI) databases, and the references of retrieved articles were also screened. The summary relative risks with 95% confidence interval for the highest versus the lowest intake of allium vegetables were calculated. Heterogeneity and publication bias were also evaluated.

RESULTS

A total of nine epidemiological studies consisting of six case-control and three prospective cohort studies were included. We found a significantly decreased risk of prostate cancer for intake of allium vegetables (OR = 0.82, 95% CI 0.70, 0.97). Moreover, in the subgroup analysis stratified by allium vegetable types, significant associations were observed for garlic (OR = 0.77, 95% CI 0.64-0.91) but not onions (OR = 0.84, 95% CI 0.62-1.13).

CONCLUSIONS

Allium vegetables, especially garlic intake, are related to decreased risk of prostate cancer. Because of the limited number of studies, further well-designed prospective studies are warranted to confirm the findings of our study.

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  • Authors+Show Affiliations

    ,

    Department of Urology, China-Japan Friendship Hospital, Beijing, China.

    ,

    Source

    MeSH

    Allium
    Case-Control Studies
    Humans
    Male
    Prognosis
    Prospective Studies
    Prostatic Neoplasms
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    23991965

    Citation

    Zhou, Xiao-Feng, et al. "Allium Vegetables and Risk of Prostate Cancer: Evidence From 132,192 Subjects." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 14, no. 7, 2013, pp. 4131-4.
    Zhou XF, Ding ZS, Liu NB. Allium vegetables and risk of prostate cancer: evidence from 132,192 subjects. Asian Pac J Cancer Prev. 2013;14(7):4131-4.
    Zhou, X. F., Ding, Z. S., & Liu, N. B. (2013). Allium vegetables and risk of prostate cancer: evidence from 132,192 subjects. Asian Pacific Journal of Cancer Prevention : APJCP, 14(7), pp. 4131-4.
    Zhou XF, Ding ZS, Liu NB. Allium Vegetables and Risk of Prostate Cancer: Evidence From 132,192 Subjects. Asian Pac J Cancer Prev. 2013;14(7):4131-4. PubMed PMID: 23991965.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Allium vegetables and risk of prostate cancer: evidence from 132,192 subjects. AU - Zhou,Xiao-Feng, AU - Ding,Zhen-Shan, AU - Liu,Nai-Bo, PY - 2013/9/3/entrez PY - 2013/9/3/pubmed PY - 2014/3/19/medline SP - 4131 EP - 4 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 14 IS - 7 N2 - OBJECTIVE: To evaluate the relationship between allium vegetable intake and risk of prostate cancer. METHODS: A systematic literature search up to May 2013 was carried out in PubMed, EMBASE, Scopus, Web of Science, Cochrane register, and Chinese National Knowledge Infrastructure (CNKI) databases, and the references of retrieved articles were also screened. The summary relative risks with 95% confidence interval for the highest versus the lowest intake of allium vegetables were calculated. Heterogeneity and publication bias were also evaluated. RESULTS: A total of nine epidemiological studies consisting of six case-control and three prospective cohort studies were included. We found a significantly decreased risk of prostate cancer for intake of allium vegetables (OR = 0.82, 95% CI 0.70, 0.97). Moreover, in the subgroup analysis stratified by allium vegetable types, significant associations were observed for garlic (OR = 0.77, 95% CI 0.64-0.91) but not onions (OR = 0.84, 95% CI 0.62-1.13). CONCLUSIONS: Allium vegetables, especially garlic intake, are related to decreased risk of prostate cancer. Because of the limited number of studies, further well-designed prospective studies are warranted to confirm the findings of our study. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/23991965/full_citation L2 - http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:23991965&key=2013.14.7.4131 DB - PRIME DP - Unbound Medicine ER -