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Oxysterols in the pathogenesis of major chronic diseases.
Redox Biol. 2013 Jan 31; 1:125-30.RB

Abstract

Pathological accumulation of 27-carbon intermediates or end-products of cholesterol metabolism, named oxysterols, may contribute to the onset and especially to the development of major chronic diseases in which inflammation, but also oxidative damage and to a certain extent cell death, are hallmarks and primary mechanisms of progression. Indeed, certain oxysterols exercise strong pro-oxidant and pro-inflammatory effects at concentrations detectable in the lesions typical of atherosclerosis, neurodegenerative diseases, inflammatory bowel diseases, age-related macular degeneration, and other pathological conditions characterized by altered cholesterol uptake and/or metabolism.

Authors+Show Affiliations

Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, Torino, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24024145

Citation

Poli, Giuseppe, et al. "Oxysterols in the Pathogenesis of Major Chronic Diseases." Redox Biology, vol. 1, 2013, pp. 125-30.
Poli G, Biasi F, Leonarduzzi G. Oxysterols in the pathogenesis of major chronic diseases. Redox Biol. 2013;1:125-30.
Poli, G., Biasi, F., & Leonarduzzi, G. (2013). Oxysterols in the pathogenesis of major chronic diseases. Redox Biology, 1, 125-30. https://doi.org/10.1016/j.redox.2012.12.001
Poli G, Biasi F, Leonarduzzi G. Oxysterols in the Pathogenesis of Major Chronic Diseases. Redox Biol. 2013 Jan 31;1:125-30. PubMed PMID: 24024145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxysterols in the pathogenesis of major chronic diseases. AU - Poli,Giuseppe, AU - Biasi,Fiorella, AU - Leonarduzzi,Gabriella, Y1 - 2013/01/31/ PY - 2012/11/23/received PY - 2012/12/03/accepted PY - 2013/9/12/entrez PY - 2013/9/12/pubmed PY - 2013/9/12/medline KW - 24-OH, 24-hydroxycholesterol KW - 27-OH, 27-hydroxycholesterol KW - 7-K, 7-ketocholesterol KW - 7α-OH, 7α-hydroxycholesterol KW - 7β-OH, 7β-hydroxycholesterol KW - AMD, Age-related macular degeneration KW - AP-1, Activator protein-1 KW - Aβ, Amyloid-β KW - ERK1/2, Extracellular signaling-regulated kinase 1/2 KW - FXR, Farnesoid X receptor KW - Human chronic diseases KW - IBD, Inflammatory bowel diseases KW - ICAM, Intercellular adhesion molecule-1 KW - IL, Interleukin KW - Inflammation KW - JNK, c-Jun N-terminal KW - LDL, Low density lipoprotein KW - LXR, Liver X receptor KW - MAPK, Mitogen-activated protein kinase KW - MCP-1, Monocyte chemotactic protein-1 KW - MIP-1β, Monocyte inflammatory protein-1β KW - MMP, Matrix metalloproteinase KW - NF-κB, Nuclear factor-κB KW - Oxidative stress KW - Oxysterols KW - PKC, Protein kinase C KW - ROS, Reactive oxygen species KW - TGFβ1, Transforming growth factor β1 KW - TIMP, Tissue inhibitors of metalloproteinases KW - TNF-α, Tumor necrosis factor-α KW - VCAM-1, Vascular cell adhesion molecule-1 KW - α-EPOX, 5α,6α-epoxycholesterol KW - β-EPOX, 5β,6β-epoxycholesterol SP - 125 EP - 30 JF - Redox biology JO - Redox Biol VL - 1 N2 - Pathological accumulation of 27-carbon intermediates or end-products of cholesterol metabolism, named oxysterols, may contribute to the onset and especially to the development of major chronic diseases in which inflammation, but also oxidative damage and to a certain extent cell death, are hallmarks and primary mechanisms of progression. Indeed, certain oxysterols exercise strong pro-oxidant and pro-inflammatory effects at concentrations detectable in the lesions typical of atherosclerosis, neurodegenerative diseases, inflammatory bowel diseases, age-related macular degeneration, and other pathological conditions characterized by altered cholesterol uptake and/or metabolism. SN - 2213-2317 UR - https://www.unboundmedicine.com/medline/citation/24024145/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/REDOX6 DB - PRIME DP - Unbound Medicine ER -