TY - JOUR T1 - Oxysterols in the pathogenesis of major chronic diseases. AU - Poli,Giuseppe, AU - Biasi,Fiorella, AU - Leonarduzzi,Gabriella, Y1 - 2013/01/31/ PY - 2012/11/23/received PY - 2012/12/03/accepted PY - 2013/9/12/entrez PY - 2013/9/12/pubmed PY - 2013/9/12/medline KW - 24-OH, 24-hydroxycholesterol KW - 27-OH, 27-hydroxycholesterol KW - 7-K, 7-ketocholesterol KW - 7α-OH, 7α-hydroxycholesterol KW - 7β-OH, 7β-hydroxycholesterol KW - AMD, Age-related macular degeneration KW - AP-1, Activator protein-1 KW - Aβ, Amyloid-β KW - ERK1/2, Extracellular signaling-regulated kinase 1/2 KW - FXR, Farnesoid X receptor KW - Human chronic diseases KW - IBD, Inflammatory bowel diseases KW - ICAM, Intercellular adhesion molecule-1 KW - IL, Interleukin KW - Inflammation KW - JNK, c-Jun N-terminal KW - LDL, Low density lipoprotein KW - LXR, Liver X receptor KW - MAPK, Mitogen-activated protein kinase KW - MCP-1, Monocyte chemotactic protein-1 KW - MIP-1β, Monocyte inflammatory protein-1β KW - MMP, Matrix metalloproteinase KW - NF-κB, Nuclear factor-κB KW - Oxidative stress KW - Oxysterols KW - PKC, Protein kinase C KW - ROS, Reactive oxygen species KW - TGFβ1, Transforming growth factor β1 KW - TIMP, Tissue inhibitors of metalloproteinases KW - TNF-α, Tumor necrosis factor-α KW - VCAM-1, Vascular cell adhesion molecule-1 KW - α-EPOX, 5α,6α-epoxycholesterol KW - β-EPOX, 5β,6β-epoxycholesterol SP - 125 EP - 30 JF - Redox biology JO - Redox Biol VL - 1 N2 - Pathological accumulation of 27-carbon intermediates or end-products of cholesterol metabolism, named oxysterols, may contribute to the onset and especially to the development of major chronic diseases in which inflammation, but also oxidative damage and to a certain extent cell death, are hallmarks and primary mechanisms of progression. Indeed, certain oxysterols exercise strong pro-oxidant and pro-inflammatory effects at concentrations detectable in the lesions typical of atherosclerosis, neurodegenerative diseases, inflammatory bowel diseases, age-related macular degeneration, and other pathological conditions characterized by altered cholesterol uptake and/or metabolism. SN - 2213-2317 UR - https://www.unboundmedicine.com/medline/citation/24024145/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/REDOX6 DB - PRIME DP - Unbound Medicine ER -