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Association between vitamin D and hepatitis C virus infection: a meta-analysis.

Abstract

AIM

To evaluate the association between 25-hydroxyvitamin D [25(OH)D] and sustained virological response (SVR) in hepatitis C virus (HCV) infected individuals.

METHODS

Relevant studies were identified by systematically searching MEDLINE databases up to March 2012 and abstracts of the European and American Congress of Hepatology conducted in 2011. Studies must provide information on SVR and the levels of 25(OH)D₃ and/or 25(OH)D₂ [henceforth referred to as 25(OH)D] in sera samples from HCV infected individuals. The inclusion criteria were: clinical studies that included HCV infected patients aged older than 18 years regardless of HCV genotype or ethnic group; provided information on SVR rates; and were reported in the English language as full papers. Due to the heterogeneity of studies in categorizing serum vitamin D levels, a cut-off value of 30 ng/mL of serum 25(OH)D was used. Heterogeneity was assessed using I² statistics. The summary odds ratios with their corresponding 95%CI were calculated based on a random-effects model.

RESULTS

Overall, 11 studies (8 observational and 3 interventional) involving 1575 individuals were included and 1117 HCV infected individuals (71%) showed low vitamin D levels. Most of the studies included mono-infected HCV individuals with the mean age ranging from 38 to 56 years. Four studies were conducted in human immunodeficiency virus/HCV infected individuals. Regarding vitamin D measurement, most of the studies employed radioimmunoassays (n = 5) followed by chemiluminescence (n = 4) and just one study employed high performance/pressure liquid chromatography (HPLC). Basal vitamin D levels varied from 17 to 43 ng/mL in the studies selected, and most of the HCV infected individuals had genotype 1 (1068/1575) with mean viral load varying from log 4.5-5.9 UI/mL. With regard to HCV treatment, most of the studies (n = 8) included HCV individuals without previous treatment, where the pooled SVR rate was 46.4%. High rates of SVR were observed in HCV individuals with vitamin D levels above 30 ng/mL (OR = 1.57; 95%CI: 1.12-2.2) and those supplemented with vitamin D (OR = 4.59; 95%CI: 1.67-12.63) regardless of genotype.

CONCLUSION

Our results demonstrated high prevalence of vitamin D deficiency and high SVR in individuals with higher serum vitamin D levels or receiving vitamin D supplementation.

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  • Authors+Show Affiliations

    ,

    Livia Melo Villar, Elisabeth Lampe, Laboratory of Viral Hepatitis, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, RJ 210360-040, Brazil.

    , , ,

    Source

    World journal of gastroenterology 19:35 2013 Sep 21 pg 5917-24

    MeSH

    25-Hydroxyvitamin D 2
    Adult
    Antiviral Agents
    Biomarkers
    Calcifediol
    Chi-Square Distribution
    Dietary Supplements
    Hepatitis C
    Humans
    Middle Aged
    Odds Ratio
    Prevalence
    Risk Factors
    Treatment Outcome
    Viral Load
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    24124339

    Citation

    Villar, Livia Melo, et al. "Association Between Vitamin D and Hepatitis C Virus Infection: a Meta-analysis." World Journal of Gastroenterology, vol. 19, no. 35, 2013, pp. 5917-24.
    Villar LM, Del Campo JA, Ranchal I, et al. Association between vitamin D and hepatitis C virus infection: a meta-analysis. World J Gastroenterol. 2013;19(35):5917-24.
    Villar, L. M., Del Campo, J. A., Ranchal, I., Lampe, E., & Romero-Gomez, M. (2013). Association between vitamin D and hepatitis C virus infection: a meta-analysis. World Journal of Gastroenterology, 19(35), pp. 5917-24. doi:10.3748/wjg.v19.i35.5917.
    Villar LM, et al. Association Between Vitamin D and Hepatitis C Virus Infection: a Meta-analysis. World J Gastroenterol. 2013 Sep 21;19(35):5917-24. PubMed PMID: 24124339.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between vitamin D and hepatitis C virus infection: a meta-analysis. AU - Villar,Livia Melo, AU - Del Campo,José Antonio, AU - Ranchal,Isidora, AU - Lampe,Elisabeth, AU - Romero-Gomez,Manuel, PY - 2012/12/14/received PY - 2013/01/31/revised PY - 2013/02/09/accepted PY - 2013/10/15/entrez PY - 2013/10/15/pubmed PY - 2014/3/14/medline KW - Hepatitis C KW - Meta-analysis KW - Sustained virological response KW - Therapy KW - Vitamin D SP - 5917 EP - 24 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 19 IS - 35 N2 - AIM: To evaluate the association between 25-hydroxyvitamin D [25(OH)D] and sustained virological response (SVR) in hepatitis C virus (HCV) infected individuals. METHODS: Relevant studies were identified by systematically searching MEDLINE databases up to March 2012 and abstracts of the European and American Congress of Hepatology conducted in 2011. Studies must provide information on SVR and the levels of 25(OH)D₃ and/or 25(OH)D₂ [henceforth referred to as 25(OH)D] in sera samples from HCV infected individuals. The inclusion criteria were: clinical studies that included HCV infected patients aged older than 18 years regardless of HCV genotype or ethnic group; provided information on SVR rates; and were reported in the English language as full papers. Due to the heterogeneity of studies in categorizing serum vitamin D levels, a cut-off value of 30 ng/mL of serum 25(OH)D was used. Heterogeneity was assessed using I² statistics. The summary odds ratios with their corresponding 95%CI were calculated based on a random-effects model. RESULTS: Overall, 11 studies (8 observational and 3 interventional) involving 1575 individuals were included and 1117 HCV infected individuals (71%) showed low vitamin D levels. Most of the studies included mono-infected HCV individuals with the mean age ranging from 38 to 56 years. Four studies were conducted in human immunodeficiency virus/HCV infected individuals. Regarding vitamin D measurement, most of the studies employed radioimmunoassays (n = 5) followed by chemiluminescence (n = 4) and just one study employed high performance/pressure liquid chromatography (HPLC). Basal vitamin D levels varied from 17 to 43 ng/mL in the studies selected, and most of the HCV infected individuals had genotype 1 (1068/1575) with mean viral load varying from log 4.5-5.9 UI/mL. With regard to HCV treatment, most of the studies (n = 8) included HCV individuals without previous treatment, where the pooled SVR rate was 46.4%. High rates of SVR were observed in HCV individuals with vitamin D levels above 30 ng/mL (OR = 1.57; 95%CI: 1.12-2.2) and those supplemented with vitamin D (OR = 4.59; 95%CI: 1.67-12.63) regardless of genotype. CONCLUSION: Our results demonstrated high prevalence of vitamin D deficiency and high SVR in individuals with higher serum vitamin D levels or receiving vitamin D supplementation. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/24124339/full_citation L2 - http://www.wjgnet.com/1007-9327/full/v19/i35/5917.htm DB - PRIME DP - Unbound Medicine ER -