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Sleep drives metabolite clearance from the adult brain.
Science. 2013 Oct 18; 342(6156):373-7.Sci

Abstract

The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep. Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.

Authors+Show Affiliations

Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24136970

Citation

Xie, Lulu, et al. "Sleep Drives Metabolite Clearance From the Adult Brain." Science (New York, N.Y.), vol. 342, no. 6156, 2013, pp. 373-7.
Xie L, Kang H, Xu Q, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013;342(6156):373-7.
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O'Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., Takano, T., Deane, R., & Nedergaard, M. (2013). Sleep drives metabolite clearance from the adult brain. Science (New York, N.Y.), 342(6156), 373-7. https://doi.org/10.1126/science.1241224
Xie L, et al. Sleep Drives Metabolite Clearance From the Adult Brain. Science. 2013 Oct 18;342(6156):373-7. PubMed PMID: 24136970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sleep drives metabolite clearance from the adult brain. AU - Xie,Lulu, AU - Kang,Hongyi, AU - Xu,Qiwu, AU - Chen,Michael J, AU - Liao,Yonghong, AU - Thiyagarajan,Meenakshisundaram, AU - O'Donnell,John, AU - Christensen,Daniel J, AU - Nicholson,Charles, AU - Iliff,Jeffrey J, AU - Takano,Takahiro, AU - Deane,Rashid, AU - Nedergaard,Maiken, PY - 2013/10/19/entrez PY - 2013/10/19/pubmed PY - 2013/12/16/medline SP - 373 EP - 7 JF - Science (New York, N.Y.) JO - Science VL - 342 IS - 6156 N2 - The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep. Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/24136970/full_citation L2 - https://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=24136970 DB - PRIME DP - Unbound Medicine ER -