TY - JOUR T1 - Sleep drives metabolite clearance from the adult brain. AU - Xie,Lulu, AU - Kang,Hongyi, AU - Xu,Qiwu, AU - Chen,Michael J, AU - Liao,Yonghong, AU - Thiyagarajan,Meenakshisundaram, AU - O'Donnell,John, AU - Christensen,Daniel J, AU - Nicholson,Charles, AU - Iliff,Jeffrey J, AU - Takano,Takahiro, AU - Deane,Rashid, AU - Nedergaard,Maiken, PY - 2013/10/19/entrez PY - 2013/10/19/pubmed PY - 2013/12/16/medline SP - 373 EP - 7 JF - Science (New York, N.Y.) JO - Science VL - 342 IS - 6156 N2 - The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep. Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/24136970/full_citation L2 - https:///www.science.org/doi/10.1126/science.1241224?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -