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Oxidative Stress and ADHD: A Meta-Analysis.
J Atten Disord 2015; 19(11):915-24JA

Abstract

OBJECTIVE

To clarify the role of oxidative stress and antioxidant activity in ADHD.

METHOD

We examined the association of ADHD and oxidative stress by applying random effects meta-analysis to studies of oxidative stress and antioxidant status in medication naive patients with ADHD and controls.

RESULTS

Six studies of a total of 231 ADHD patients and 207 controls met our selection criteria. The association between ADHD and antioxidant status was not significant. We found a significant association between ADHD and oxidative stress that could not be accounted for by publication bias. The significant association lost significance after correcting for intrastudy clustering. No one observation accounted for the positive result.

CONCLUSION

These results are preliminary given the small number of studies. They suggest that patients with ADHD have normal levels of antioxidant production, but that their response to oxidative stress is insufficient, leading to oxidative damage.

Authors+Show Affiliations

State University of New York Upstate Medical University, Syracuse, USA.State University of New York Upstate Medical University, Syracuse, USA.State University of New York Upstate Medical University, Syracuse, USA.State University of New York Upstate Medical University, Syracuse, USA sfaraone@childpsychresearch.org.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

24232168

Citation

Joseph, Nidhin, et al. "Oxidative Stress and ADHD: a Meta-Analysis." Journal of Attention Disorders, vol. 19, no. 11, 2015, pp. 915-24.
Joseph N, Zhang-James Y, Perl A, et al. Oxidative Stress and ADHD: A Meta-Analysis. J Atten Disord. 2015;19(11):915-24.
Joseph, N., Zhang-James, Y., Perl, A., & Faraone, S. V. (2015). Oxidative Stress and ADHD: A Meta-Analysis. Journal of Attention Disorders, 19(11), pp. 915-24. doi:10.1177/1087054713510354.
Joseph N, et al. Oxidative Stress and ADHD: a Meta-Analysis. J Atten Disord. 2015;19(11):915-24. PubMed PMID: 24232168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative Stress and ADHD: A Meta-Analysis. AU - Joseph,Nidhin, AU - Zhang-James,Yanli, AU - Perl,Andras, AU - Faraone,Stephen V, Y1 - 2013/11/14/ PY - 2013/11/16/entrez PY - 2013/11/16/pubmed PY - 2016/4/19/medline KW - ADHD KW - meta-analysis SP - 915 EP - 24 JF - Journal of attention disorders JO - J Atten Disord VL - 19 IS - 11 N2 - OBJECTIVE: To clarify the role of oxidative stress and antioxidant activity in ADHD. METHOD: We examined the association of ADHD and oxidative stress by applying random effects meta-analysis to studies of oxidative stress and antioxidant status in medication naive patients with ADHD and controls. RESULTS: Six studies of a total of 231 ADHD patients and 207 controls met our selection criteria. The association between ADHD and antioxidant status was not significant. We found a significant association between ADHD and oxidative stress that could not be accounted for by publication bias. The significant association lost significance after correcting for intrastudy clustering. No one observation accounted for the positive result. CONCLUSION: These results are preliminary given the small number of studies. They suggest that patients with ADHD have normal levels of antioxidant production, but that their response to oxidative stress is insufficient, leading to oxidative damage. SN - 1557-1246 UR - https://www.unboundmedicine.com/medline/citation/24232168/full_citation L2 - http://journals.sagepub.com/doi/full/10.1177/1087054713510354?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -