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Oxidative Stress and ADHD: A Meta-Analysis.

Abstract

OBJECTIVE

To clarify the role of oxidative stress and antioxidant activity in ADHD.

METHOD

We examined the association of ADHD and oxidative stress by applying random effects meta-analysis to studies of oxidative stress and antioxidant status in medication naive patients with ADHD and controls.

RESULTS

Six studies of a total of 231 ADHD patients and 207 controls met our selection criteria. The association between ADHD and antioxidant status was not significant. We found a significant association between ADHD and oxidative stress that could not be accounted for by publication bias. The significant association lost significance after correcting for intrastudy clustering. No one observation accounted for the positive result.

CONCLUSION

These results are preliminary given the small number of studies. They suggest that patients with ADHD have normal levels of antioxidant production, but that their response to oxidative stress is insufficient, leading to oxidative damage.

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  • Authors+Show Affiliations

    ,

    State University of New York Upstate Medical University, Syracuse, USA.

    ,

    State University of New York Upstate Medical University, Syracuse, USA.

    ,

    State University of New York Upstate Medical University, Syracuse, USA.

    State University of New York Upstate Medical University, Syracuse, USA sfaraone@childpsychresearch.org.

    Source

    Journal of attention disorders 19:11 2015 Nov pg 915-24

    MeSH

    Antioxidants
    Attention Deficit Disorder with Hyperactivity
    Female
    Humans
    Male
    Oxidative Stress

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    24232168

    Citation

    Joseph, Nidhin, et al. "Oxidative Stress and ADHD: a Meta-Analysis." Journal of Attention Disorders, vol. 19, no. 11, 2015, pp. 915-24.
    Joseph N, Zhang-James Y, Perl A, et al. Oxidative Stress and ADHD: A Meta-Analysis. J Atten Disord. 2015;19(11):915-24.
    Joseph, N., Zhang-James, Y., Perl, A., & Faraone, S. V. (2015). Oxidative Stress and ADHD: A Meta-Analysis. Journal of Attention Disorders, 19(11), pp. 915-24. doi:10.1177/1087054713510354.
    Joseph N, et al. Oxidative Stress and ADHD: a Meta-Analysis. J Atten Disord. 2015;19(11):915-24. PubMed PMID: 24232168.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oxidative Stress and ADHD: A Meta-Analysis. AU - Joseph,Nidhin, AU - Zhang-James,Yanli, AU - Perl,Andras, AU - Faraone,Stephen V, Y1 - 2013/11/14/ PY - 2013/11/16/entrez PY - 2013/11/16/pubmed PY - 2016/4/19/medline KW - ADHD KW - meta-analysis SP - 915 EP - 24 JF - Journal of attention disorders JO - J Atten Disord VL - 19 IS - 11 N2 - OBJECTIVE: To clarify the role of oxidative stress and antioxidant activity in ADHD. METHOD: We examined the association of ADHD and oxidative stress by applying random effects meta-analysis to studies of oxidative stress and antioxidant status in medication naive patients with ADHD and controls. RESULTS: Six studies of a total of 231 ADHD patients and 207 controls met our selection criteria. The association between ADHD and antioxidant status was not significant. We found a significant association between ADHD and oxidative stress that could not be accounted for by publication bias. The significant association lost significance after correcting for intrastudy clustering. No one observation accounted for the positive result. CONCLUSION: These results are preliminary given the small number of studies. They suggest that patients with ADHD have normal levels of antioxidant production, but that their response to oxidative stress is insufficient, leading to oxidative damage. SN - 1557-1246 UR - https://www.unboundmedicine.com/medline/citation/24232168/full_citation L2 - http://journals.sagepub.com/doi/full/10.1177/1087054713510354?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -