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Blood-based biomarkers for Parkinson's disease.
Parkinsonism Relat Disord 2014; 20 Suppl 1:S99-103PR

Abstract

There is a pressing need for biomarkers to diagnose Parkinson's disease (PD), assess disease severity, and prognosticate course. Various types of biologic specimens are potential candidates for identifying biomarkers--defined here as surrogate indicators of physiological or pathophysiological states--but blood has the advantage of being minimally invasive to obtain. There are, however, several challenges to identifying biomarkers in blood. Several candidate biomarkers identified in other diseases or in other types of biological fluids are being pursued as blood-based biomarkers in PD. In addition, unbiased discovery is underway using techniques including metabolomics, proteomics, and gene expression profiling. In this review, we summarize these techniques and discuss the challenges and successes of blood-based biomarker discovery in PD. Blood-based biomarkers that are discussed include α-synuclein, DJ-1, uric acid, epidermal growth factor, apolipoprotein-A1, and peripheral inflammatory markers.

Authors+Show Affiliations

Parkinson's Disease and Movement Disorders Center, Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address: lamachahine@hotmail.com.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24262199

Citation

Chahine, Lama M., et al. "Blood-based Biomarkers for Parkinson's Disease." Parkinsonism & Related Disorders, vol. 20 Suppl 1, 2014, pp. S99-103.
Chahine LM, Stern MB, Chen-Plotkin A. Blood-based biomarkers for Parkinson's disease. Parkinsonism Relat Disord. 2014;20 Suppl 1:S99-103.
Chahine, L. M., Stern, M. B., & Chen-Plotkin, A. (2014). Blood-based biomarkers for Parkinson's disease. Parkinsonism & Related Disorders, 20 Suppl 1, pp. S99-103. doi:10.1016/S1353-8020(13)70025-7.
Chahine LM, Stern MB, Chen-Plotkin A. Blood-based Biomarkers for Parkinson's Disease. Parkinsonism Relat Disord. 2014;20 Suppl 1:S99-103. PubMed PMID: 24262199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood-based biomarkers for Parkinson's disease. AU - Chahine,Lama M, AU - Stern,Matthew B, AU - Chen-Plotkin,Alice, PY - 2013/11/23/entrez PY - 2013/11/23/pubmed PY - 2014/7/12/medline KW - Blood-based biomarkers KW - Metabolomics KW - Parkinson's disease KW - Proteomics SP - S99 EP - 103 JF - Parkinsonism & related disorders JO - Parkinsonism Relat. Disord. VL - 20 Suppl 1 N2 - There is a pressing need for biomarkers to diagnose Parkinson's disease (PD), assess disease severity, and prognosticate course. Various types of biologic specimens are potential candidates for identifying biomarkers--defined here as surrogate indicators of physiological or pathophysiological states--but blood has the advantage of being minimally invasive to obtain. There are, however, several challenges to identifying biomarkers in blood. Several candidate biomarkers identified in other diseases or in other types of biological fluids are being pursued as blood-based biomarkers in PD. In addition, unbiased discovery is underway using techniques including metabolomics, proteomics, and gene expression profiling. In this review, we summarize these techniques and discuss the challenges and successes of blood-based biomarker discovery in PD. Blood-based biomarkers that are discussed include α-synuclein, DJ-1, uric acid, epidermal growth factor, apolipoprotein-A1, and peripheral inflammatory markers. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/24262199/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(13)70025-7 DB - PRIME DP - Unbound Medicine ER -