Sugar-sweetened beverage intake and the risk of type I and type II endometrial cancer among postmenopausal women.
BACKGROUNDSugar-sweetened beverage (SSB) intake has been associated with an increased risk of obesity and type II diabetes. However, its association with endometrial cancer is unclear.
METHODSWe evaluated dietary intake of SSB, fruit juice, sugar-free beverages, sweets/baked goods, starch, and sugars among 23,039 postmenopausal women in the Iowa Women's Health Study. Incident estrogen-dependent type I and estrogen-independent type II endometrial cancers were identified via linkage with the Surveillance Epidemiology and End Results Registry. Risks of type I and type II endometrial cancers were separately compared by energy-adjusted dietary intake in Cox proportional hazards regression models.
RESULTSFrom 1986 to 2010, 506 type I and 89 type II incident endometrial cancers were identified. An increased risk of type I endometrial cancer was observed with increasing SSB intake after adjustment for body mass index (BMI) and other cofounders (Ptrend = 0.0005). Compared with nondrinkers of SSB, the risk was 78% higher [95% confidence intervals (CI), 1.32-2.40] among women in the highest quintile of SSB intake. The observed association was not modified by BMI, physical activity, history of diabetes, or cigarette smoking. Higher risk of type I endometrial cancer was also observed with higher intake of sugars. None of the dietary items included in the analysis was associated with type II endometrial cancer risk.
CONCLUSIONHigher intake of SSB and sugars was associated with an increased risk of type I, but not type II, endometrial cancer.
IMPACTSSB intake may be a risk factor for type I endometrial cancer regardless of other lifestyle factors.
Authors' Affiliations: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis; Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine; Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minnesota; and Department of Epidemiology and Biostatistics, School of Public Health and Health Services, George Washington University, Washington, District of Columbia., , ,
Body Mass Index
Proportional Hazards Models
Surveys and Questionnaires
Pub Type(s)Journal Article
Research Support, N.I.H., Extramural